Publications by authors named "Jack W Singer"

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Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures.
Jack W Singer, Suliman Al-Fayoumi, Jason Taylor, Sharlene Velichko, Alison O'Mahony

PLoS One· April 2020

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Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306).
Ruth Pettengell, Monika Długosz-Danecka, David Andorsky, David Belada, Pencho Georgiev, Jack W Singer

Br J Haematol· January 2020

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Predictive models for splenic response to JAK-inhibitor therapy in patients with myelofibrosis.
Kamal Menghrajani, Philip S Boonstra, Jessica A Mercer, Cecelia Perkins, Krisstina L Gowin, Jack W Singer

Leuk Lymphoma· April 2019

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Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes.
Mona M Hosseini, Stephen E Kurtz, Sherif Abdelhamed, Shawn Mahmood, Monika A Davare, Jack W Singer

Leukemia· November 2018

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Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy.
Jack W Singer, Angela Fleischman, Suliman Al-Fayoumi, John O Mascarenhas, Qiang Yu

Oncotarget· September 2018

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Pacritinib vs Best Available Therapy, Including Ruxolitinib, in Patients With Myelofibrosis: A Randomized Clinical Trial.
John Mascarenhas, Ronald Hoffman, Moshe Talpaz, Aaron T Gerds, Brady Stein, Jack W Singer

JAMA Oncol· May 2018

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Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis.
Suliman Al-Fayoumi, Taishi Hashiguchi, Yuka Shirakata, John Mascarenhas, Jack W Singer

J Exp Pharmacol· May 2018

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Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial.
Ruben A Mesa, Alessandro M Vannucchi, Adam Mead, Miklos Egyed, Anita Szoke, Jack W Singer

Lancet Haematol· May 2017

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Colony-Stimulating Factor-1 Receptor Is Required for Nurse-like Cell Survival in Chronic Lymphocytic Leukemia.
Avery Polk, Ye Lu, Tianjiao Wang, Erlene Seymour, Nathanael G Bailey, Jack W Singer

Clin Cancer Res· December 2016

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Phase 1/2 study of pacritinib, a next generation JAK2/FLT3 inhibitor, in myelofibrosis or other myeloid malignancies.
Srdan Verstovsek, Olatoyosi Odenike, Jack W Singer, Tanya Granston, Suliman Al-Fayoumi

J Hematol Oncol· December 2016

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Monotherapy with pixantrone in histologically confirmed relapsed or refractory aggressive B-cell non-Hodgkin lymphoma: post-hoc analyses from a phase III trial.
Ruth Pettengell, Catherine Sebban, Pier Luigi Zinzani, Hans Gunter Derigs, Sergey Kravchenko, Jack W Singer

Br J Haematol· September 2016

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Comprehensive kinase profile of pacritinib, a nonmyelosuppressive Janus kinase 2 inhibitor.
Jack W Singer, Suliman Al-Fayoumi, Haiching Ma, Rami S Komrokji, Ruben Mesa

J Exp Pharmacol· August 2016

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Synergistic effect of pacritinib with erlotinib on JAK2-mediated resistance in epidermal gowth factor receptor mutation-positive non-small cell lung Cancer.
Nobuaki Ochi, Hideko Isozaki, Masami Takeyama, Jack W Singer, Hiromichi Yamane

Exp Cell Res· June 2016

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The Cost-effectiveness of Pixantrone for Third/Fourth-line Treatment of Aggressive Non-Hodgkin's Lymphoma.
Noemi Muszbek, Ananth Kadambi, Tereza Lanitis, Anthony J Hatswell, Dilip Patel, Jack W Singer

Clin Ther· March 2016

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Phase II study of tosedostat with cytarabine or decitabine in newly diagnosed older patients with acute myeloid leukaemia or high-risk MDS.
Raya Mawad, Pamela S Becker, Paul Hendrie, Bart Scott, Brent L Wood, Jack W Singer

Br J Haematol· January 2016

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Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin.
Monica Longo, Paola Della Torre, Cecilia Allievi, Alberto Morisetti, Suliman Al-Fayoumi, Jack W Singer

Reprod Toxicol· July 2014

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The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: insight to explain the cardiac safety of pixantrone in doxorubicin-treated patients.
Emanuela Salvatorelli, Pierantonio Menna, Odalys Gonzalez Paz, Massimo Chello, Elvio Covino, Jack W Singer

J Pharmacol Exp Ther· February 2013

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Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial.
Ruth Pettengell, Bertrand Coiffier, Geetha Narayanan, Fernando Hurtado de Mendoza, Raghunadharao Digumarti, Jack W Singer

Lancet Oncol· July 2012

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Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: phase 1 study with a dose-expansion cohort.
Tomasz P Srokowski, James E Liebmann, Manuel R Modiano, Gary I Cohen, Barbara Pro, Jack W Singer

Cancer· November 2011

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Phase I/II study of pixantrone in combination with cyclophosphamide, vincristine, and prednisone in patients with relapsed aggressive non-Hodgkin lymphoma.
Peter Borchmann, Raoul Herbrecht, Martin Wilhelm, Franck Morschhauser, Georg Hess, Jack W Singer

Leuk Lymphoma· April 2011

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Procoagulant inhibitory properties of paclitaxel poliglumex.
John Nemunaitis, Neil Senzer, Barry Cooper, Michael Nemunaitis, Cynthia Bedell, Jack W Singer

Int J Gen Med· December 2010

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Novel bis-platinum complexes endowed with an improved pharmacological profile.
Laura Gatti, Paola Perego, Roberto Leone, Piero Apostoli, Nives Carenini, Jack W Singer

Mol Pharm· February 2010

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Single-agent versus combination chemotherapy in patients with advanced non-small cell lung cancer and a performance status of 2: prognostic factors and treatment selection based on two large randomized clinical trials.
Rogerio Lilenbaum, Victoria M Villaflor, Corey Langer, Kenneth O'Byrne, Mary O'Brien, Jack W Singer

J Thorac Oncol· July 2009

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A phase I and pharmacokinetic study of paclitaxel poliglumex and cisplatin in patients with advanced solid tumors.
Claire F Verschraegen, Keith Skubitz, Adil Daud, Andrzej P Kudelka, Ian Rabinowitz, Jack W Singer

Cancer Chemother Pharmacol· April 2009

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Putting a cost on extra days given by drugs.
Jack W Singer

Pharos Alpha Omega Alpha Honor Med Soc· September 2008

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