Publications by authors named "Jacklyn N Hellwege"

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Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.
Michael J Betti, James Jaworski, Shilin Zhao, J Sunil Rao, Bríd M Ryan, Jacklyn N Hellwege

Am J Hum Genet· September 2025

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Genomics-informed drug-repurposing strategy identifies two therapeutic targets for preventing liver disease associated with metabolic dysfunction.
Hannah M Seagle, Alexis T Akerele, Joseph A DeCorte, Jacklyn N Hellwege, Joseph H Breeyear

Am J Hum Genet· August 2025

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Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.
Catherine A Greene, Gabrielle Hampton, James Jaworski, Megan M Shuey, Atlas Khan, Jacklyn N Hellwege

Nat Commun· August 2025

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A phenome-wide association study of uterine fibroids reveals a marked burden of comorbidities.
Elizabeth A Jasper, Brian S Mautz, Jacklyn N Hellwege, Jacqueline A Piekos, Sarah H Jones

Commun Med (Lond)· May 2025

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Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.
Jeewoo Kim, Ariel Williams, Hannah Noh, Elizabeth A Jasper, Sarah H Jones, Jacklyn N Hellwege

Nat Commun· March 2025

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Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.
Hongbo Liu, Amin Abedini, Eunji Ha, Ziyuan Ma, Xin Sheng, Jacklyn N Hellwege

Science· February 2025

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Genomics-Informed Drug Repurposing Strategy Identifies Novel Therapeutic Targets for Metabolic Dysfunction-Associated Steatotic Liver Disease.
Hannah M Seagle, Alexis T Akerele, Joseph A DeCorte, Jacklyn N Hellwege, Joseph H Breeyear

medRxiv· February 2025

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Genetically Predicted Gene Expression Effects on Changes in Red Blood Cell and Plasma Polyunsaturated Fatty Acids.
Nikhil K Khankari, Timothy Su, Qiuyin Cai, Lili Liu, Elizabeth A Jasper, Jacklyn N Hellwege

Genet Epidemiol· January 2025

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Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.
Catherine A Greene, Gabrielle Hampton, James Jaworski, Megan M Shuey, Atlas Khan, Jacklyn N Hellwege

medRxiv· January 2025

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Genomic insights into gestational weight gain uncover tissue-specific mechanisms and pathways.
Elizabeth A Jasper, Jacklyn N Hellwege, Catherine A Greene, Todd L Edwards, Digna R Velez Edwards

NPJ Womens Health· December 2024

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Constructing a multi-ancestry polygenic risk score for uterine fibroids using publicly available data highlights need for inclusive genetic research.
Jessica L G Winters, Jacqueline A Piekos, Jacklyn N Hellwege, Ozan Dikilitas, Iftikhar J Kullo

Pac Symp Biocomput· December 2024

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Uterine fibroids show evidence of shared genetic architecture with blood pressure traits.
Alexis T Akerele, Jacqueline A Piekos, Jeewoo Kim, Nikhil K Khankari, Jacklyn N Hellwege

Pac Symp Biocomput· December 2024

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Genetically predicted gene expression effects on changes in red blood cell and plasma polyunsaturated fatty acids.
Nikhil K Khankari, Timothy Su, Qiuyin Cai, Lili Liu, Elizabeth A Jasper, Jacklyn N Hellwege

medRxiv· December 2024

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Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.
Marlena Fejzo, Xinran Wang, Julia Zöllner, Natàlia Pujol-Gualdo, Triin Laisk, Jacklyn N Hellwege

Res Sq· December 2024

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Development of electronic health record based algorithms to identify individuals with diabetic retinopathy.
Joseph H Breeyear, Sabrina L Mitchell, Cari L Nealon, Jacklyn N Hellwege, Brian Charest

J Am Med Inform Assoc· November 2024

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Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.
Marlena Fejzo, Xinran Wang, Julia Zöllner, Natàlia Pujol-Gualdo, Triin Laisk, Jacklyn N Hellwege

medRxiv· November 2024

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Adaptive selection at G6PD and disparities in diabetes complications.
Joseph H Breeyear, Jacklyn N Hellwege, Philip H Schroeder, John S House, Hannah M Poisner

Nat Med· September 2024

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Variance quantitative trait loci reveal gene-gene interactions which alter blood traits.
Yash Pershad, Hannah Poisner, Robert W Corty, Jacklyn N Hellwege, Alexander G Bick

medRxiv· September 2024

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Genome-wide association study of hospitalized patients and acute kidney injury.
Edward D Siew, Jacklyn N Hellwege, Adriana M Hung, Bethany C Birkelo, Andrew J Vincz

Kidney Int· August 2024

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Genetic predictors of blood pressure traits are associated with preeclampsia.
Elizabeth A Jasper, Jacklyn N Hellwege, Joseph H Breeyear, Brenda Xiao, Gail P Jarvik

Sci Rep· July 2024

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A new test for trait mean and variance detects unreported loci for blood-pressure variation.
Joseph H Breeyear, Brian S Mautz, Jacob M Keaton, Jacklyn N Hellwege, Eric S Torstenson

Am J Hum Genet· May 2024

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Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.
Jacob M Keaton, Zoha Kamali, Tian Xie, Ahmad Vaez, Ariel Williams, Jacklyn N Hellwege

Nat Genet· May 2024

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EVALUATING THE RELATIONSHIPS BETWEEN GENETIC ANCESTRY AND THE CLINICAL PHENOME.
Jacqueline A Piekos, Jeewoo Kim, Jacob M Keaton, Jacklyn N Hellwege, Todd L Edwards

Pac Symp Biocomput· January 2024

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X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.
Markus Scholz, Katrin Horn, Janne Pott, Matthias Wuttke, Andreas Kühnapfel, Jacklyn N Hellwege

Nat Commun· January 2024

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Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program.
Nicole D Armstrong, Vinodh Srinivasasainagendra, Farah Ammous, Themistocles L Assimes, Amber L Beitelshees, Jacklyn N Hellwege

Front Genet· December 2023

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