Publications by authors named "Jaclyn L Henderson"

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SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.
Heike J Wobst, Andreu Viader, Giovanni Muncipinto, Ryan Hollibaugh, Daniel van Kalken, Jaclyn L Henderson

JCI Insight· November 2024

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Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
Tamara Halkina, Jaclyn L Henderson, Edward Y Lin, Martin K Himmelbauer, J Howard Jones

J Med Chem· May 2021

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Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites.
Gregory M Dillon, Jaclyn L Henderson, Channa Bao, John A Joyce, Michael Calhoun

PLoS One· July 2020

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Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
Jaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, Karen J Coffman, Jayasankar Jasti

J Med Chem· January 2015

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Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Paul Galatsis, Jaclyn L Henderson, Bethany L Kormos, Seungil Han, Ravi G Kurumbail

Bioorg Med Chem Lett· September 2014

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Tandem thia-Fries rearrangement--cyclisation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate benzyne precursors.
Catherine Hall, Jaclyn L Henderson, Guillaume Ernouf, Michael F Greaney

Chem Commun (Camb)· September 2013

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Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
Suvi T M Orr, Sharon L Ripp, T Eric Ballard, Jaclyn L Henderson, Dennis O Scott

J Med Chem· June 2012

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Palladium-catalyzed N-arylation of 2-aminothiazoles.
Meredeth A McGowan, Jaclyn L Henderson, Stephen L Buchwald

Org Lett· March 2012

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Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases.
Debabrata Maiti, Brett P Fors, Jaclyn L Henderson, Yoshinori Nakamura, Stephen L Buchwald

Chem Sci· January 2011

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Palladium-catalyzed amination of unprotected halo-7-azaindoles.
Jaclyn L Henderson, Sarah M McDermott, Stephen L Buchwald

Org Lett· October 2010

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Efficient Pd-catalyzed amination reactions for heterocycle functionalization.
Jaclyn L Henderson, Stephen L Buchwald

Org Lett· October 2010

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The benzyne aza-Claisen reaction.
Alastair A Cant, Guillaume H V Bertrand, Jaclyn L Henderson, Lee Roberts, Michael F Greaney

Angew Chem Int Ed Engl· September 2009

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Biaryl synthesis via palladium-catalyzed aryne multicomponent coupling.
Jaclyn L Henderson, Andrew S Edwards, Michael F Greaney

Org Lett· December 2007

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Three-component coupling of benzyne: domino intermolecular carbopalladation.
Jaclyn L Henderson, Andrew S Edwards, Michael F Greaney

J Am Chem Soc· June 2006

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