Publications by authors named "Sharon L Ripp"

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A Case to Support the Continued Use of Rifampin in Clinical Drug-Drug Interaction Studies.
Joel P Bercu, David J Ponting, Sharon L Ripp, Krista L Dobo, Rheem A Totah

Clin Pharmacol Ther· July 2024

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Comparative nonclinical assessments of the biosimilar PF-06410293 and originator adalimumab.
Mazin Derzi, Ahmed M Shoieb, Sharon L Ripp, Gregory L Finch, Leslie G Lorello

Regul Toxicol Pharmacol· April 2020

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In Vitro and In Vivo Investigation of Potential for Complex CYP3A Interaction for PF-00251802 (Dagrocorat), a Novel Dissociated Agonist of the Glucocorticoid Receptor.
Sharon L Ripp, Arnab Mukherjee, Heather Eng, Thomas Stock, Dona Fleishaker

Clin Pharmacol Drug Dev· March 2018

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Effect of moxidectin on CYP3A4 activity as evaluated by oral midazolam pharmacokinetics in healthy subjects.
Joan M Korth-Bradley, Virginia Parks, Frank Wagner, Stephan Chalon, Ian Gourley, Sharon L Ripp

Clin Pharmacol Drug Dev· March 2014

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DHEA metabolites activate estrogen receptors alpha and beta.
Kristy K Michael Miller, Numan Al-Rayyan, Margarita M Ivanova, Kathleen A Mattingly, Sharon L Ripp

Steroids· January 2013

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Non-clinical safety assessment and toxicokinetics of voriconazole and anidulafungin in the juvenile rat: a combination study design in support of a Paediatric Investigation Plan.
David M Cross, Gary Chmielewski, Elise M Lewis, Lei Liu, Michael S Modesitt, Sharon L Ripp

Regul Toxicol Pharmacol· June 2012

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Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
Suvi T M Orr, Sharon L Ripp, T Eric Ballard, Jaclyn L Henderson, Dennis O Scott

J Med Chem· June 2012

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.
Raman Sharma, Timothy J Strelevitz, Hongying Gao, Alan J Clark, Klaas Schildknegt, Sharon L Ripp

Drug Metab Dispos· March 2012

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Tissue distribution of anidulafungin in neonatal rats.
Sharon L Ripp, Jalal A Aram, Christopher J Bowman, Gary Chmielewski, Umberto Conte

Birth Defects Res B Dev Reprod Toxicol· February 2012

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Evaluation of models for predicting drug-drug interactions due to induction.
Odette A Fahmi, Sharon L Ripp

Expert Opin Drug Metab Toxicol· November 2010

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Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Amy S Antipas, Laura C Blumberg, William H Brissette, Matthew F Brown, Jeffrey M Casavant, Sharon L Ripp

Bioorg Med Chem Lett· July 2010

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Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.
Thomas V Magee, Sharon L Ripp, Bryan Li, Richard A Buzon, Lou Chupak

J Med Chem· December 2009

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The identification of orally bioavailable thrombopoietin agonists.
Michael J Munchhof, Amy S Antipas, Laura C Blumberg, William H Brissette, Matthew F Brown, Sharon L Ripp

Bioorg Med Chem Lett· March 2009

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Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators.
Viola Tamasi, Kristy K Michael Miller, Sharon L Ripp, Ermin Vila, Thomas E Geoghagen

Mol Pharmacol· March 2008

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A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Amit S Kalgutkar, James Driscoll, Sabrina X Zhao, Gregory S Walker, Richard M Shepard, Sharon L Ripp

Chem Res Toxicol· December 2007

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Pyrimidine benzamide-based thrombopoietin receptor agonists.
Lawrence A Reiter, Chakrapani Subramanyam, Emilio J Mangual, Christopher S Jones, Marc I Smeets, Sharon L Ripp

Bioorg Med Chem Lett· October 2007

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The time to move cytochrome p450 induction into mainstream pharmacology is long overdue.
Dennis A Smith, Maurice Dickins, Odette A Fahmi, Kazuhide Iwasaki, Caroline Lee, Sharon L Ripp

Drug Metab Dispos· April 2007

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Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases.
Renee J Krause, Steven C Glocke, Anna Rita Sicuri, Sharon L Ripp, Adnan A Elfarra

Chem Res Toxicol· December 2006

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Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.
Sharon L Ripp, Jessica B Mills, Odette A Fahmi, Kristen A Trevena, Jennifer L Liras

Drug Metab Dispos· October 2006

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Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals.
David S Riddick, Chunja Lee, Anahita Bhathena, Yoav E Timsit, Po-Yung Cheng, Sharon L Ripp

Drug Metab Dispos· April 2004

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Stereo- and regioselectivity account for the diversity of dehydroepiandrosterone (DHEA) metabolites produced by liver microsomal cytochromes P450.
Kristy K Michael Miller, Jian Cai, Sharon L Ripp, William M Pierce, Thomas H Rushmore

Drug Metab Dispos· March 2004

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Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene.
Sharon L Ripp, K Cameron Falkner, Mary L Pendleton, Viola Tamasi, Russell A Prough

Mol Pharmacol· July 2003

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Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases?
Boaz Robinzon, Kristy K Michael, Sharon L Ripp, Stephen J Winters, Russell A Prough

Arch Biochem Biophys· April 2003

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Dehydroepiandrosterone affects the expression of multiple genes in rat liver including 11 beta-hydroxysteroid dehydrogenase type 1: a cDNA array analysis.
Shi Gu, Sharon L Ripp, Russell A Prough, Thomas E Geoghegan

Mol Pharmacol· March 2003

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Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.
Sharon L Ripp, Jennifer L Fitzpatrick, Jeffrey M Peters, Russell A Prough

Drug Metab Dispos· May 2002

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