Publications by authors named "Jacob Ayers"

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Correlation Between Fungal and Bacterial Populations in Periodontitis Through Targeted Sequencing: A Pilot Study.
Jacob Ayers, Jennifer Chinnici, Amarpreet Sabharwal, Pinar Emecen-Huja, Hua-Hong Chien

J Clin Med· September 2025

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Comparative effectiveness of lumbar interbody fusion techniques in adult scoliosis: a systematic review and meta-analysis of postoperative alignment and disability outcomes.
Zachary Taylor, David Gomez, Blake Nygaard, Spencer Newell, Zak Sabetta, Jacob Ayers

J Spine Surg· September 2025

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Severe neurodegeneration in brains of transgenic rats producing human tau prions.
Jacob Ayers, T Peter Lopez, Ian T Steele, Abby Oehler, Rigo Roman-Albarran

Acta Neuropathol· August 2024

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Nonviral Delivery of CRISPR-Cas9 Using Protein-Agnostic, High-Loading Porous Silicon and Polymer Nanoparticles.
R Brock Fletcher, Larry D Stokes, Isom B Kelly, Katelyn M Henderson, Isabel C Vallecillo-Viejo, Jacob Ayers

ACS Nano· September 2023

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice.
Jacob I Ayers, Guilian Xu, Qing Lu, Kristy Dillon, Susan Fromholt

Viruses· August 2023

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Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.
Carlo Condello, Jacob I Ayers, Clifton L Dalgard, M Madhy Garcia Garcia, Brianna M Rivera

Proc Natl Acad Sci U S A· March 2023

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Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics.
Daniel R Wong, Jay Conrad, Noah Johnson, Jacob Ayers, Annelies Laeremans

Nat Mach Intell· June 2022

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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
Jacob I Ayers, Joanne Lee, Octovia Monteiro, Amanda L Woerman, Ann A Lazar

Proc Natl Acad Sci U S A· February 2022

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Phenotypic diversity in ALS and the role of poly-conformational protein misfolding.
Jacob I Ayers, David R Borchelt

Acta Neuropathol· July 2021

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Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components.
Evan Lester, Felicia K Ooi, Nadine Bakkar, Jacob Ayers, Amanda L Woerman

Neuron· May 2021

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Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence.
Jacob I Ayers, Guilian Xu, Kristy Dillon, Qing Lu, Zhijuan Chen

Acta Neuropathol Commun· May 2021

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Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates.
Yuxing Xia, Zhijuan Chen, Guilian Xu, David R Borchelt, Jacob I Ayers

Neurosci Lett· January 2021

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Expanding spectrum of prion diseases.
Jacob I Ayers, Nick A Paras, Stanley B Prusiner

Emerg Top Life Sci· September 2020

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
Anthony Crown, Luke McAlary, Eric Fagerli, Hilda Brown, Justin J Yerbury, Jacob I Ayers

PLoS One· April 2020

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Prion protein - mediator of toxicity in multiple proteinopathies.
Jacob I Ayers, Stanley B Prusiner

Nat Rev Neurol· April 2020

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ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons.
Zachary Osking, Jacob I Ayers, Ryan Hildebrandt, Kristen Skruber, Hilda Brown

iScience· September 2019

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Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models.
Keith Crosby, Anthony M Crown, Brittany L Roberts, Hilda Brown, Jacob I Ayers

PLoS One· April 2019

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Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis.
Anthony M Crown, Brittany L Roberts, Keith Crosby, Hilda Brown, Jacob I Ayers

G3 (Bethesda)· March 2019

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ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons.
Zachary Osking, Jacob I Ayers, Ryan Hildebrandt, Kristen Skruber, Hilda Brown

iScience· January 2019

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Prion-like mechanisms in amyotrophic lateral sclerosis.
Jacob I Ayers, Neil R Cashman

Handb Clin Neurol· September 2018

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Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts.
Jacob I Ayers, Cara J Riffe, Zachary A Sorrentino, Jeffrey Diamond, Eric Fagerli

J Virol· September 2018

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Adsorption and decontamination of α-synuclein from medically and environmentally-relevant surfaces.
Hanh T M Phan, Jason C Bartz, Jacob Ayers, Benoit I Giasson, Mathias Schubert

Colloids Surf B Biointerfaces· June 2018

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Prion-like Spreading in Tauopathies.
Jacob I Ayers, Benoit I Giasson, David R Borchelt

Biol Psychiatry· February 2018

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Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding.
Sanaz Rasouli, Alireza Abdolvahabi, Corbin M Croom, Devon L Plewman, Yunhua Shi, Jacob I Ayers

J Biol Chem· November 2017

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Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.
Jacob I Ayers, Mieu M Brooks, Nicola J Rutherford, Jasie K Howard, Zachary A Sorrentino

J Virol· January 2017

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