Publications by authors named "Nick A Paras"

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Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy.
Nicholas L Yan, Francisco Candido, Eric Tse, Arthur A Melo, Stanley B Prusiner, Nick A Paras

FEBS Lett· January 2025

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Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs.
Jay Conrad, Nick A Paras, Roy J Vaz

J Med Chem· April 2024

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Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.
Gregory E Merz, Matthew J Chalkley, Sophia K Tan, Eric Tse, Joanne Lee, Nick A Paras

Nat Commun· May 2023

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Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics.
Daniel R Wong, Jay Conrad, Noah Johnson, Jacob Ayers, Annelies Laeremans, Nick A Paras

Nat Mach Intell· June 2022

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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
Jacob I Ayers, Joanne Lee, Octovia Monteiro, Amanda L Woerman, Ann A Lazar, Nick A Paras

Proc Natl Acad Sci U S A· February 2022

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Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent.
Terrence-Thang H Nguyen, Connor J O'Brien, Minh L N Tran, Steven H Olson, Nicholas S Settineri, Nick A Paras

Org Lett· May 2021

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Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles.
Cedric Lozano, Cristian Ramirez, Ny Sin, Hélène M-F Viart, Stanley B Prusiner, Nick A Paras

ACS Omega· April 2021

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Expanding spectrum of prion diseases.
Jacob I Ayers, Nick A Paras, Stanley B Prusiner

Emerg Top Life Sci· September 2020

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Selectivity in the Addition of Electron Deficient Radicals to the 2 Position of Indoles.
Yi Li, Roy J Vaz, Steven H Olson, Mark Munson, Nick A Paras

European J Org Chem· September 2020

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Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.
Jean-Marc M Grandjean, Alexander Y Jiu, John W West, Atsushi Aoyagi, Daniel G Droege, Nick A Paras

ACS Med Chem Lett· February 2020

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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Sean Caenepeel, Sean P Brown, Brian Belmontes, Gordon Moody, Kathleen S Keegan, Nick A Paras

Cancer Discov· December 2018

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Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism.
Connor J O'Brien, Daniel G Droege, Alexander Y Jiu, Shivaani S Gandhi, Nick A Paras

J Org Chem· August 2018

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Convenient route to secondary sulfinates: application to the stereospecific synthesis of α-C-chiral sulfonamides.
Michael G Johnson, Michael W Gribble, Jonathan B Houze, Nick A Paras

Org Lett· December 2014

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Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.
Adrian L Smith, Frenel F DeMorin, Nick A Paras, Qi Huang, Jeffrey K Petkus

J Med Chem· October 2009

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Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids.
Barry A Bunin, Jeffrey M Dener, Daphne E Kelly, Nick A Paras, James D Tario

J Comb Chem· May 2005

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The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to alpha,beta-unsaturated aldehydes.
Nick A Paras, David W C MacMillan

J Am Chem Soc· July 2002

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