Publications by authors named "Jacob I Contreras"

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Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Satish Sagar, Sarbjit Singh, Jayapal Reddy Mallareddy, Yogesh A Sonawane, John V Napoleon, Jacob I Contreras

Eur J Med Chem· October 2021

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Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK.
Sandeep Rana, Smit Kour, Yogesh A Sonawane, Caroline M Robb, Jacob I Contreras

Chem Biol Drug Des· August 2020

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Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.
Caroline M Robb, Smit Kour, Jacob I Contreras, Ekta Agarwal, Carter J Barger

Oncotarget· June 2020

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CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax.
Smit Kour, Sandeep Rana, Jacob I Contreras, Hannah M King, Caroline M Robb

Mol Pharmacol· October 2019

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Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein.
Mohammad Abid, Yogesh A Sonawane, Jacob I Contreras, Sandeep Rana, Amarnath Natarajan

Curr Med Chem· October 2018

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Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.
Jacob I Contreras, Caroline M Robb, Hannah M King, Jared Baxter, Ayrianne J Crawford

ACS Chem Biol· May 2018

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Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.
Caroline M Robb, Smit Kour, Jacob I Contreras, Ekta Agarwal, Carter J Barger

Oncotarget· January 2018

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Developing Polyamine-Based Peptide Amphiphiles with Tunable Morphology and Physicochemical Properties.
Mehdi Bin Samad, Yashpal Singh Chhonker, Jacob I Contreras, Alec McCarthy, Megan M McClanahan

Macromol Biosci· August 2017

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Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.
Revital Yefidoff-Freedman, Jing Fan, Lu Yan, Qingwen Zhang, Guillermo Rodrigo Reis Dos Santos, Jacob I Contreras

J Med Chem· July 2017

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Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
Caroline M Robb, Jacob I Contreras, Smit Kour, Margaret A Taylor, Mohammad Abid

Chem Commun (Camb)· July 2017

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Discovery and characterization of small molecule Rac1 inhibitors.
Jamie L Arnst, Ashley L Hein, Margaret A Taylor, Nick Y Palermo, Jacob I Contreras

Oncotarget· May 2017

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Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy.
Yogesh A Sonawane, Margaret A Taylor, John Victor Napoleon, Sandeep Rana, Jacob I Contreras

J Med Chem· October 2016

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Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study.
Sandeep Rana, Elizabeth C Blowers, Calvin Tebbe, Jacob I Contreras, Prakash Radhakrishnan

J Med Chem· May 2016

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