Publications by authors named "Jacob Leander"

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A machine learning approach to population pharmacokinetic modelling automation.
Sam Richardson, Itziar Irurzun Arana, Andrzej Nowojewski, Diansong Zhou, Jacob Leander

Commun Med (Lond)· July 2025

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A stochastic mixed effects model to assess treatment effects and fluctuations in home-measured peak expiratory flow and the association with exacerbation risk in asthma.
Jacob Leander, Mats Jirstrand, Ulf G Eriksson, Robert Palmér

CPT Pharmacometrics Syst Pharmacol· February 2022

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A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases.
Jacob Leander, Mikael Sunnåker, Dinko Rekić, Sergey Aksenov, Ulf G Eriksson

J Pharmacokinet Pharmacodyn· August 2021

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Higher Febuxostat Exposure Observed in Asian Compared with Caucasian Subjects Independent of Bodyweight.
Dinko Rekić, Susanne Johansson, Jacob Leander

Clin Pharmacokinet· March 2021

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Estimation of Equipotent Doses for Anti-Inflammatory Effects of Prednisolone and AZD9567, an Oral Selective Nonsteroidal Glucocorticoid Receptor Modulator.
Joachim Almquist, Muhammad Waqas Sadiq, Ulf G Eriksson, Tove Hegelund Myrbäck, Susanne Prothon, Jacob Leander

CPT Pharmacometrics Syst Pharmacol· August 2020

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Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials.
Tove Hegelund Myrbäck, Susanne Prothon, Karl Edman, Jacob Leander, Mahdi Hashemi

Lancet Rheumatol· January 2020

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Exact Gradients Improve Parameter Estimation in Nonlinear Mixed Effects Models with Stochastic Dynamics.
Helga Kristin Olafsdottir, Jacob Leander, Joachim Almquist, Mats Jirstrand

AAPS J· August 2018

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Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood.
Joachim Almquist, Jacob Leander, Mats Jirstrand

J Pharmacokinet Pharmacodyn· June 2015

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Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats.
Jacob Leander, Joachim Almquist, Christine Ahlström, Johan Gabrielsson, Mats Jirstrand

AAPS J· May 2015

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Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague-Dawley rats after different routes of administration of nicotinic acid.
Sofia Tapani, Joachim Almquist, Jacob Leander, Christine Ahlström, Lambertus A Peletier

J Pharm Sci· August 2014

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Stochastic differential equations as a tool to regularize the parameter estimation problem for continuous time dynamical systems given discrete time measurements.
Jacob Leander, Torbjörn Lundh, Mats Jirstrand

Math Biosci· May 2014

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