Publications by authors named "Jacob Myerson"

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Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity.
Nicolas Marzolini, Taylor V Brysgel, Ryan J Rahman, Eno-Obong Essien, Saw Y Nwe, Jacob W Myerson

bioRxiv· October 2025

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Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage.
Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco E Zamora, Soomin Jeong, Jacob W Myerson

J Neuroinflammation· October 2025

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Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.
Serena Omo-Lamai, Yufei Wang, Manthan N Patel, Aleksa Milosavljevic, Daniel Zuschlag, Jacob W Myerson

Nat Nanotechnol· September 2025

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Tropomyosin 1 promotes platelet adhesion and clot contraction separate from its roles in developmental hematopoiesis.
Po-Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A Marcos-Contreras, Kim Ha, Jacob W Myerson

bioRxiv· August 2025

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A percolation phase transition controls complement protein coating of surfaces.
Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco Zamora, Alireza Ebrahimimojarad, Jacob W Myerson

Cell· July 2025

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Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.
Vladimir V Shuvaev, Ying K Tam, Benjamin W Lee, Jacob W Myerson, Alan Herbst

Proc Natl Acad Sci U S A· July 2025

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Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage.
Sahily Reyes-Esteves, Aparajeeta Majumder, Nicolas Marzolini, Marco Zamora, Yufei Wang, Jacob Myerson

Res Sq· April 2025

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Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude.
Jia Nong, Xijing Gong, Quang Minh Dang, Sachchidanand Tiwari, Manthan Patel, Jacob W Myerson

bioRxiv· February 2025

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Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation.
Michael H Zaleski, Liam S Chase, Elizabeth D Hood, Zhicheng Wang, Jia Nong, Jacob W Myerson

Adv Mater· February 2025

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Biomechanical and Functional Features of the Carrier Erythrocytes Prolonging Circulation Time of Biotherapeutic Targeted to Glycophorin A.
Alina D Peshkova, Taylor V Brysgel, Parth Mody, Jia Nong, Zhicheng Wang, Jacob W Myerson

Bioconjug Chem· February 2025

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Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy.
Michael H Zaleski, Serena Omo-Lamai, Jia Nong, Liam S Chase, Jacob W Myerson

J Control Release· October 2024

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A percolation-type criticality threshold controls immune protein coating of surfaces.
Zhicheng Wang, Sahil Kulkarni, Jia Nong, Marco Zamora, Alireza Ebrahimimojarad, Jacob W Myerson

bioRxiv· October 2024

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Marginated Neutrophils in the Lungs Effectively Compete for Nanoparticles Targeted to the Endothelium, Serving as a Part of the Reticuloendothelial System.
Marco E Zamora, Eno-Obong Essien, Kartik Bhamidipati, Aditi Murthy, Jing Liu, Jacob W Myerson

ACS Nano· August 2024

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Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions.
Serena Omo-Lamai, Marco E Zamora, Manthan N Patel, Jichuan Wu, Jia Nong, Jacob W Myerson

Adv Mater· June 2024

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Controlling spatial distribution of functional lipids in a supported lipid bilayer prepared from vesicles.
Hyun-Su Lee, Ye Chan Kim, Zhicheng Wang, Jacob S Brenner, Vladimir R Muzykantov, Jacob W Myerson

J Colloid Interface Sci· June 2024

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Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke.
Jia Nong, Patrick M Glassman, Vladimir V Shuvaev, Sahily Reyes-Esteves, Helene C Descamps, Jacob W Myerson

Mol Ther· May 2024

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Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting.
Marco E Zamora, Serena Omo-Lamai, Manthan N Patel, Jichuan Wu, Evguenia Arguiri, Jacob W Myerson

Nano Lett· April 2024

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Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects.
Serena Omo-Lamai, Yufei Wang, Manthan N Patel, Eno-Obong Essien, Mengwen Shen, Jacob W Myerson

bioRxiv· April 2024

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Effective Prevention of Arterial Thrombosis with Albumin-Thrombin Inhibitor Conjugates.
Oscar A Marcos-Contreras, Jacob W Myerson, Jia Nong, Jacob Samuel Brenner, Vladimir R Muzykantov

Mol Pharm· November 2023

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Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain.
Jia Nong, Patrick M Glassman, Jacob W Myerson, Viviana Zuluaga-Ramirez, Alba Rodriguez-Garcia

ACS Nano· July 2023

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Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions.
Serena Omo-Lamai, Marco E Zamora, Manthan N Patel, Jichuan Wu, Jia Nong, Jacob W Myerson

bioRxiv· July 2023

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Targeting lipid nanoparticles to the blood brain barrier to ameliorate acute ischemic stroke.
Jia Nong, Patrick M Glassman, Sahily Reyes-Esteves, Helene C Descamps, Vladimir V Shuvaev, Jacob W Myerson

bioRxiv· June 2023

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Meta-analysis of material properties influencing nanoparticle plasma pharmacokinetics.
Briana Macedo, Manthan Patel, Michael H Zaleski, Parth Mody, Xiaonan Ma, Jacob W Myerson

Int J Pharm· May 2023

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Targeted drug delivery to the brain endothelium dominates over passive delivery via vascular leak in experimental intracerebral hemorrhage.
Sahily Reyes-Esteves, Jia Nong, Patrick M Glassman, Serena Omo-Lamai, Sarah Ohashi, Jacob W Myerson

J Control Release· April 2023

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Mechanisms by Which Liposomes Improve Inhaled Drug Delivery for Alveolar Diseases.
Laura T Ferguson, Xiaonan Ma, Jacob W Myerson, Jichuan Wu, Patrick M Glassman

Adv Nanobiomed Res· March 2023

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