Publications by authors named "Jacob Roth"

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Productive mRNA chromatin escape is promoted by PRMT5 activity.
Joseph D DeAngelo, Maxim I Maron, Jacob S Roth, Subray Hegde, Aliza M Silverstein

Mol Cell· November 2025

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[Clinical Ethics Consultation: Ethics matter to all of us!].
Eva Katharina Masel, Lorenz Faihs, Sabine Pleschberger, Jacob Roth, Bruno K Podesser

Wien Klin Wochenschr· November 2025

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SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.
Ke Kong, Wei Zhao, Jonathan H Shrimp, Marius Vava, Rohan Sinha, Jacob S Roth

J Med Chem· September 2025

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Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters.
Jacob S Roth, Hui Guo, Lu Chen, Min Shen, Omotola Gbadegesin

bioRxiv· July 2025

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PRMT5 activity sustains histone production to maintain genome integrity.
Jacob S Roth, Joseph D DeAngelo, Dejauwne L Young, Maxim I Maron, Ankita Saha

bioRxiv· July 2025

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Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency.
Dejauwne L Young, Jennifer Aguilan, Ronald Cutler, Stephanie Stransky, Joseph D DeAngelo, Jacob S Roth

bioRxiv· April 2025

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Nursing home staff's experiences with the implementation of an automated blister packaging system for solid, orally ingestible drugs: a qualitative study in Northern Italy.
Waltraud Tappeiner, Heike Wieser, Rita Obkircher, Jessica Pigneter, Jacob Roth

BMJ Open· December 2024

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Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB.
Joseph D DeAngelo, Maxim I Maron, Jacob S Roth, Aliza M Silverstein, Varun Gupta

bioRxiv· August 2024

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Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma.
Stacey Stauffer, Jacob S Roth, Edjay R Hernandez, Joshua T Kowalczyk, Nancy E Sealover

Cancers (Basel)· June 2024

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Birinapant selectively enhances immunotoxin-mediated killing of cancer cells conditional on the IAP protein levels within target cells.
Antonella Antignani, Maria Teresa Bilotta, Jacob S Roth, Daniel J Urban, Min Shen

FASEB J· December 2023

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The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models.
Katie E Hebron, Xiaolin Wan, Jacob S Roth, David J Liewehr, Nancy E Sealover

Clin Cancer Res· January 2023

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PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by Mutation in Pediatric Acute Lymphoblastic Leukemia.
Jianping Li, Julia Hlavka-Zhang, Jonathan H Shrimp, Crissandra Piper, Daphne Dupéré-Richér, Jacob S Roth

Cancer Discov· January 2022

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Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation.
Maxim I Maron, Alyssa D Casill, Varun Gupta, Jacob S Roth, Simone Sidoli

Elife· January 2022

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Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter.
Robert W Robey, Andrea N Robinson, Fatima Ali-Rahmani, Lyn M Huff, Sabrina Lusvarghi, Jacob S Roth

Sci Rep· December 2021

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Niche space of corals along the Florida reef tract.
Robert van Woesik, Lynnette M Roth, Elizabeth J Brown, Kelly R McCaffrey, Jacob R Roth

PLoS One· July 2020

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Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences.
Jacob S Roth, Tobie D Lee, Dorian M Cheff, Maya L Gosztyla, Rosita R Asawa

SLAS Discov· June 2020

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Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19.
Richard T Eastman, Jacob S Roth, Kyle R Brimacombe, Anton Simeonov, Min Shen

ACS Cent Sci· June 2020

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Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19.
Richard T Eastman, Jacob S Roth, Kyle R Brimacombe, Anton Simeonov, Min Shen

ACS Cent Sci· May 2020

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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
Sara E Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R Brimacombe, Mark J Henderson, Caitlin Lynch, Jacob S Roth

ACS Cent Sci· December 2018

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Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
Shyh-Ming Yang, Natalia J Martinez, Adam Yasgar, Carina Danchik, Catrine Johansson, Jacob Roth

J Med Chem· June 2018

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A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.
Natalia J Martinez, Rosita R Asawa, Matthew G Cyr, Alexey Zakharov, Daniel J Urban, Jacob S Roth

Sci Rep· June 2018

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