Publications by authors named "Jacob Witten"

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Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.
Jacob Witten, Idris Raji, Rajith S Manan, Emily Beyer, Sandra Bartlett

Nat Biotechnol· November 2025

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Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA.
Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M Raimondo, Jacob Witten

Nat Biomed Eng· February 2025

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Author Correction: Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA.
Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M Raimondo, Jacob Witten

Nat Biomed Eng· February 2025

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NumSimEX: A method using EXX hydrogen exchange mass spectrometry to map the energetics of protein folding landscapes.
Jasper A G Flint, Jacob Witten, Isabella Han, John Strahan, Jovan Damjanovic

Protein Sci· February 2025

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Inhalable Dry Powders for Lung mRNA Delivery.
Akiva Gordon, Bowen Li, Jacob Witten, Hong Nguyen, Daniel G Anderson

Adv Healthc Mater· November 2024

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Zwitterionic Polymer-Functionalized Lipid Nanoparticles for the Nebulized Delivery of mRNA.
Allen Y Jiang, Sushil Lathwal, Sabrina Meng, Jacob Witten, Emily Beyer

J Am Chem Soc· November 2024

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Combinatorial development of nebulized mRNA delivery formulations for the lungs.
Allen Y Jiang, Jacob Witten, Idris O Raji, Feyisayo Eweje, Corina MacIsaac

Nat Nanotechnol· March 2024

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Recent advances in nanoparticulate RNA delivery systems.
Jacob Witten, Yizong Hu, Robert Langer, Daniel G Anderson

Proc Natl Acad Sci U S A· March 2024

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Comparison of Physicochemical Properties of Native Mucus and Reconstituted Mucin Gels.
Caroline E Wagner, Miri Krupkin, Kathryn B Smith-Dupont, Chloe M Wu, Nicole A Bustos, Jacob Witten

Biomacromolecules· February 2023

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Spatial configuration of charge and hydrophobicity tune particle transport through mucus.
Tahoura Samad, Jacob Witten, Alan J Grodzinsky, Katharina Ribbeck

Biophys J· January 2022

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Computational Insights into Avidity of Polymeric Multivalent Binders.
Emiko Zumbro, Jacob Witten, Alfredo Alexander-Katz

Biophys J· September 2019

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Molecular Characterization of Mucus Binding.
Jacob Witten, Tahoura Samad, Katharina Ribbeck

Biomacromolecules· April 2019

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Mucus and Mucin Environments Reduce the Efficacy of Polymyxin and Fluoroquinolone Antibiotics against .
Tahoura Samad, Julia Y Co, Jacob Witten, Katharina Ribbeck

ACS Biomater Sci Eng· March 2019

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Selective permeability of mucus barriers.
Jacob Witten, Tahoura Samad, Katharina Ribbeck

Curr Opin Biotechnol· August 2018

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Charge Influences Substrate Recognition and Self-Assembly of Hydrophobic FG Sequences.
Wesley G Chen, Jacob Witten, Scott C Grindy, Niels Holten-Andersen, Katharina Ribbeck

Biophys J· November 2017

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The particle in the spider's web: transport through biological hydrogels.
Jacob Witten, Katharina Ribbeck

Nanoscale· June 2017

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Mapping Protein Conformational Landscapes under Strongly Native Conditions with Hydrogen Exchange Mass Spectrometry.
Jacob Witten, Amy Ruschak, Timothy Poterba, Alexis Jaramillo, Andrew D Miranker

J Phys Chem B· August 2015

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Micro-heterogeneity metrics for diffusion in soft matter.
John Mellnik, Paula A Vasquez, Scott A McKinley, Jacob Witten, David B Hill

Soft Matter· October 2014

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Vortex Counter-Current Chromatography: Performance of a New Preparative Column.
Yoichiro Ito, Robert Clary, Jacob J Witten, Yun Zeng

Chromatographia· October 2012

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Preparation of two novel monobrominated 2-(2',4'-dihydroxybenzoyl)-3,4,5,6-tetrachlorobenzoic acids and their separation from crude synthetic mixtures using vortex counter-current chromatography.
Adrian Weisz, Jacob J Witten, Yun Zeng, Eugene P Mazzola, Yoichiro Ito

J Chromatogr A· May 2012

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