Publications by authors named "Jacqueline Linehan"

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Intracellular trafficking SNARE protein, syntaxin-6, modifies prion cellular phenotypes and risk of disease development in vivo.
Elizabeth Hill, Mitali Patel, Juan M Ribes, Jacqueline Linehan, Fuquan Zhang

Acta Neuropathol· November 2025

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Isolation of a novel human prion strain from a PRNP codon 129 heterozygous vCJD patient.
Fuquan Zhang, Susan Joiner, Jacqueline M Linehan, Florin Pintilii, Tamsin Nazari

PLoS Pathog· February 2025

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Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.
Emma Jones, Elizabeth Hill, Jacqueline Linehan, Tamsin Nazari, Adam Caulder

Neurobiol Dis· January 2024

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DNA methylation analysis of archival lymphoreticular tissues in Creutzfeldt-Jakob disease.
Fernando Guntoro, Emmanuelle Viré, Chiara Giordani, Lee Darwent, Holger Hummerich, Jacqueline Linehan

Acta Neuropathol· October 2022

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Overexpression of mouse prion protein in transgenic mice causes a non-transmissible spongiform encephalopathy.
Graham S Jackson, Jacqueline Linehan, Sebastian Brandner, Emmanuel A Asante, Jonathan D F Wadsworth

Sci Rep· October 2022

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Humanized Transgenic Mice Are Resistant to Chronic Wasting Disease Prions From Norwegian Reindeer and Moose.
Jonathan D F Wadsworth, Susan Joiner, Jacqueline M Linehan, Kezia Jack, Huda Al-Doujaily

J Infect Dis· September 2022

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Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme.
Simon Mead, Azadeh Khalili-Shirazi, Caroline Potter, Tzehow Mok, Akin Nihat, Jacqueline Linehan

Lancet Neurol· April 2022

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Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study.
Emma Jones, Holger Hummerich, Emmanuelle Viré, James Uphill, Athanasios Dimitriadis, Jacqueline Linehan

Lancet Neurol· October 2020

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Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic.
O Noel Gill, Yvonne Spencer, Angela Richard-Loendt, Carole Kelly, David Brown, Jacqueline Linehan

Acta Neuropathol· June 2020

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Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.
Emmanuel A Asante, Jacqueline M Linehan, Andrew Tomlinson, Tatiana Jakubcova, Shyma Hamdan

PLoS Biol· June 2020

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Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.
Silvia A Purro, Mark A Farrow, Jacqueline Linehan, Tamsin Nazari, David X Thomas

Nature· December 2018

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Methods for Molecular Diagnosis of Human Prion Disease.
Jonathan D F Wadsworth, Gary Adamson, Susan Joiner, Lara Brock, Caroline Powell, Jacqueline M Linehan

Methods Mol Biol· May 2018

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Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein.
Susan Joiner, Emmanuel A Asante, Jacqueline M Linehan, Lara Brock, Sebastian Brandner

J Neurol Sci· March 2018

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Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system.
Chris McKinnon, Rob Goold, Ralph Andre, Anny Devoy, Zaira Ortega, Jacqueline M Linehan

Acta Neuropathol· March 2016

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A systematic investigation of production of synthetic prions from recombinant prion protein.
Christian Schmidt, Jeremie Fizet, Francesca Properzi, Mark Batchelor, Malin K Sandberg, Jacqueline M Linehan

Open Biol· December 2015

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Erratum: Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy.
Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D F Wadsworth, Andrew J Nicoll, Jacqueline Linehan

Nature· October 2015

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Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy.
Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D F Wadsworth, Andrew J Nicoll, Jacqueline Linehan

Nature· September 2015

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Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS.
Emmanuel A Asante, Andrew Grimshaw, Michelle Smidak, Tatiana Jakubcova, Andrew Tomlinson, Jacqueline M Linehan

PLoS Pathog· July 2015

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A naturally occurring variant of the human prion protein completely prevents prion disease.
Emmanuel A Asante, Michelle Smidak, Andrew Grimshaw, Richard Houghton, Andrew Tomlinson, Jacqueline M Linehan

Nature· June 2015

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A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.
Adam Wenborn, Cassandra Terry, Nathalie Gros, Susan Joiner, Laura D'Castro, Jacqueline M Linehan

Sci Rep· May 2015

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N-terminal domain of prion protein directs its oligomeric association.
Clare R Trevitt, Laszlo L P Hosszu, Mark Batchelor, Silvia Panico, Cassandra Terry, Jacqueline M Linehan

J Biol Chem· September 2014

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Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.
Malin K Sandberg, Huda Al-Doujaily, Bernadette Sharps, Michael Wiggins De Oliveira, Christian Schmidt, Jacqueline M Linehan

Nat Commun· July 2014

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Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity.
Igor Klyubin, Andrew J Nicoll, Azadeh Khalili-Shirazi, Michael Farmer, Stephanie Canning, Jacqueline Linehan

J Neurosci· April 2014

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Variant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein.
Simon Mead, Jonathan D F Wadsworth, Marie-Claire Porter, Jacqueline M Linehan, Wojciech Pietkiewicz

JAMA Neurol· March 2014

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Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases.
Lilla Reiniger, Ilaria Mirabile, Ana Lukic, Jonathan Df Wadsworth, Jacqueline M Linehan

Acta Neuropathol Commun· May 2013

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