Publications by authors named "Ralph Andre"

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Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons.
Jenny Lange, Alison Wood-Kaczmar, Aneesa Ali, Sahar Farag, Rhia Ghosh, Ralph Andre

Front Cell Neurosci· September 2021

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Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species.
Grace C O'Regan, Sahar H Farag, Caroline S Casey, Alison Wood-Kaczmar, Jennifer M Pocock, Ralph Andre

J Neuroinflammation· April 2021

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Wild-type huntingtin regulates human macrophage function.
Grace C O'Regan, Sahar H Farag, Gary R Ostroff, Sarah J Tabrizi, Ralph Andre

Sci Rep· October 2020

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Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.
Rhia Ghosh, Alison Wood-Kaczmar, Lucianne Dobson, Edward J Smith, Eva C Sirinathsinghji, Andrey Y Abramov, Ralph Andre

FASEB J· June 2020

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Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington's disease by etanercept treatment.
Jeffrey Pido-Lopez, Benedict Tanudjojo, Sahar Farag, Marie-Katrin Bondulich, Ralph Andre

Sci Rep· May 2019

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FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
Robert Goold, Michael Flower, Davina Hensman Moss, Chris Medway, Alison Wood-Kaczmar, Ralph Andre

Hum Mol Genet· February 2019

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In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington's disease.
Jeffrey Pido-Lopez, Ralph Andre, Agnesska C Benjamin, Nadira Ali, Sahar Farag

Sci Rep· July 2018

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Structural imaging in premanifest and manifest Huntington disease.
Rachael I Scahill, Ralph Andre, Sarah J Tabrizi, Elizabeth H Aylward

Handb Clin Neurol· March 2018

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Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.
James R C Miller, Edith L Pfister, Wanzhao Liu, Ralph Andre, Ulrike Träger

Sci Rep· April 2017

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RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation.
James R C Miller, Kitty K Lo, Ralph Andre, Davina J Hensman Moss, Ulrike Träger

Hum Mol Genet· July 2016

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Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.
James R C Miller, Ulrike Träger, Ralph Andre, Sarah J Tabrizi

PLoS One· June 2016

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Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system.
Chris McKinnon, Rob Goold, Ralph Andre, Anny Devoy, Zaira Ortega

Acta Neuropathol· March 2016

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Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis.
Ralph Andre, Lucy Carty, Sarah J Tabrizi

Curr Opin Pharmacol· February 2016

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An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Sigurd D Süssmuth, Salman Haider, G Bernhard Landwehrmeyer, Ruth Farmer, Chris Frost, Ralph Andre

Br J Clin Pharmacol· March 2015

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Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models.
Ulrike Träger, Ralph Andre, Anna Magnusson-Lind, James R C Miller, Colúm Connolly, Andreas Weiss

Neurobiol Dis· January 2015

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Quantitative polymerase chain reaction.
James R C Miller, Ralph Andre

Br J Hosp Med (Lond)· December 2014

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A critical evaluation of inflammatory markers in Huntington's Disease plasma.
Edina Silajdžić, Melinda Rezeli, Ákos Végvári, Nayana Lahiri, Ralph Andre

J Huntingtons Dis· September 2014

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Biomarker development for Huntington's disease.
Ralph Andre, Rachael I Scahill, Salman Haider, Sarah J Tabrizi

Drug Discov Today· July 2014

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HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.
Ulrike Träger, Ralph Andre, Nayana Lahiri, Anna Magnusson-Lind, Andreas Weiss

Brain· March 2014

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Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.
Luisa Massai, Lara Petricca, Letizia Magnoni, Luca Rovetini, Salman Haider, Ralph Andre, Andrea Caricasole

BMC Biochem· November 2013

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Mutant huntingtin impairs immune cell migration in Huntington disease.
Wanda Kwan, Ulrike Träger, Dimitrios Davalos, Austin Chou, Jill Bouchard, Ralph Andre, Andreas Weiss

J Clin Invest· December 2012

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Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression.
Andreas Weiss, Ulrike Träger, Edward J Wild, Stephan Grueninger, Ruth Farmer, Ralph Andre

J Clin Invest· October 2012

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Misfolded PrP and a novel mechanism of proteasome inhibition.
Ralph Andre, Sarah J Tabrizi

Prion· August 2012

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Huntington's disease: fighting on many fronts.
Ralph Andre, Edward J Wild, Sarah J Tabrizi

Brain· April 2012

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Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.
Pelagia Deriziotis, Ralph André, David M Smith, Rob Goold, Kerri J Kinghorn

EMBO J· July 2011

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