Publications by authors named "Jennifer M Pocock"

Claim this Profile
F
First-in-Class SAM-Competitive G9a Inhibitor FLAV-27 as a Disease-Modifying Therapy for Alzheimer's Disease.
Aina Bellver-Sanchis, David Valle-Garcia, Carla Barbaraci, Fernando Romero-Becerra, Rohit Kumar Singh, Jennifer M Pocock

Mol Ther· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Amelioration of signaling deficits underlying metabolic shortfall in TREM2 human iPSC-derived microglia.
Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pocock

FEBS J· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia.
Charles Arber, Jackie M Casey, Samuel Crawford, Naiomi Rambarack, Umran Yaman, Jennifer M Pocock

Acta Neuropathol· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Microglia produce the amyloidogenic ABri peptide in familial British dementia.
Charles Arber, Jackie M Casey, Samuel Crawford, Naiomi Rambarack, Umran Yaman, Jennifer M Pocock

bioRxiv· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Jennifer M Pocock

Glia· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model.
Jingzhang Wei, Charles Arber, Selina Wray, John Hardy, Thomas M Piers, Jennifer M Pocock

Glia· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells.
Christophe Boudesco, Annelies Nonneman, Alessandro Cinti, Paola Picardi, Loredana Redaelli, Jennifer M Pocock

Glia· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Naciye Magusali, Andrew C Graham, Thomas M Piers, Pantila Panichnantakul, Umran Yaman, Jennifer M Pocock

Brain· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Iqra Nazish, Charles Arber, Thomas M Piers, Thomas T Warner, John A Hardy, Jennifer M Pocock

Neurochem Int· July 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M Piers, James Staddon, Jennifer M Pocock

Sci Rep· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species.
Grace C O'Regan, Sahar H Farag, Caroline S Casey, Alison Wood-Kaczmar, Jennifer M Pocock

J Neuroinflammation· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.
Anna Mallach, Johan Gobom, Henrik Zetterberg, John Hardy, Thomas M Piers, Jennifer M Pocock

Brain Commun· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Jennifer M Pocock

Hum Mol Genet· November 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, Jennifer M Pocock

FASEB J· February 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Amyloid precursor protein processing in human neurons with an allelic series of the intron 4 deletion mutation and total presenilin-1 knockout.
Charles Arber, Claudio Villegas-Llerena, Jamie Toombs, Jennifer M Pocock, Natalie S Ryan

Brain Commun· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity.
Thomas M Piers, Emma East, Claudio Villegas-Llerena, Ioanna G Sevastou, Mar Matarin, Jennifer M Pocock

Front Cell Neurosci· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Xianyuan Xiang, Thomas M Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Jennifer M Pocock

Mol Neurodegener· September 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Modelling microglial function with induced pluripotent stem cells: an update.
Jennifer M Pocock, Thomas M Piers

Nat Rev Neurosci· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis.
Jenny Lange, Luke J Haslett, Emyr Lloyd-Evans, Jennifer M Pocock, Mark S Sands

Acta Neuropathol Commun· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Pablo Garcia-Reitboeck, Alexandra Phillips, Thomas M Piers, Claudio Villegas-Llerena, Matt Butler, Jennifer M Pocock

Cell Rep· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study.
Claire L Russell, Amanda Heslegrave, Vikram Mitra, Henrik Zetterberg, Jennifer M Pocock

Rapid Commun Mass Spectrom· January 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Plant-Derived Chalcone 2,2',5'-Trihydroxychalcone Provides Neuroprotection against Toll-Like Receptor 4 Triggered Inflammation in Microglia.
Manasi Jiwrajka, Alexandra Phillips, Matt Butler, Miriam Rossi, Jennifer M Pocock

Oxid Med Cell Longev· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease.
Mona Sadeghian, Gizem Mullali, Jennifer M Pocock, Thomas Piers, Arthur Roach

Neuropathol Appl Neurobiol· August 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Claudio Villegas-Llerena, Alexandra Phillips, Pablo Garcia-Reitboeck, John Hardy, Jennifer M Pocock

Curr Opin Neurobiol· February 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration.
Joseph Jebelli, Claudie Hooper, Jennifer M Pocock

Neurosci Lett· November 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis