Publications by authors named "Arthur Roach"

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Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop.
Roger A Barker, Mart Saarma, Clive N Svendsen, Catherine Morgan, Alan Whone, Arthur Roach

J Parkinsons Dis· November 2024

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The Qualification of an Enrichment Biomarker for Clinical Trials Targeting Early Stages of Parkinson's Disease.
Diane Stephenson, Derek Hill, Jesse M Cedarbaum, Maria Tome, Spiros Vamvakas, Arthur Roach

J Parkinsons Dis· June 2020

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Molecular Neuroimaging of the Dopamine Transporter as a Patient Enrichment Biomarker for Clinical Trials for Early Parkinson's Disease.
Klaus Romero, Daniela Conrado, Jackson Burton, Timothy Nicholas, Vikram Sinha, Arthur Roach

Clin Transl Sci· May 2019

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The Qualification of an Enrichment Biomarker for Clinical Trials Targeting Early Stages of Parkinson's Disease.
Diane Stephenson, Derek Hill, Jesse M Cedarbaum, Maria Tome, Spiros Vamvakas, Arthur Roach

J Parkinsons Dis· January 2019

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Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease.
Mona Sadeghian, Gizem Mullali, Jennifer M Pocock, Thomas Piers, Arthur Roach

Neuropathol Appl Neurobiol· August 2016

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Safinamide reduces dyskinesias and prolongs L-DOPA antiparkinsonian effect in parkinsonian monkeys.
Laurent Grégoire, Vincent A Jourdain, Matthew Townsend, Arthur Roach, Thérèse Di Paolo

Parkinsonism Relat Disord· May 2013

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Tremorolytic effects of safinamide in animal models of drug-induced parkinsonian tremor.
Samantha Podurgiel, Lyndsey E Collins-Praino, Samantha Yohn, Patrick A Randall, Arthur Roach

Pharmacol Biochem Behav· April 2013

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Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis.
Damineh Morsali, David Bechtold, Woojin Lee, Summen Chauhdry, Upayan Palchaudhuri, Arthur Roach

Brain· April 2013

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Chemical inducers and transcriptional markers of oligodendrocyte differentiation.
Lara Joubert, Isabelle Foucault, Yves Sagot, Lilia Bernasconi, François Duval, Arthur Roach

J Neurosci Res· September 2010

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The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
Catherine R Burton, Jere E Meredith, Donna M Barten, Margi E Goldstein, Carol M Krause, Arthur H Roach

J Biol Chem· August 2008

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In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties.
Tiziana Adage, Anne-Cécile Trillat, Anna Quattropani, Dominique Perrin, Laurent Cavarec, Arthur Roach

Eur Neuropsychopharmacol· March 2008

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Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors.
Michael G Yang, Jian-Liang Shi, Dilip P Modi, Jennifer Wells, Brian M Cochran, Arthur H Roach

Bioorg Med Chem Lett· July 2007

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Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
Lorin A Thompson, Ann Y Liauw, Mercy M Ramanjulu, Padmaja Kasireddy-Polam, Stephen E Mercer, Arthur H Roach

Bioorg Med Chem Lett· May 2006

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Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.
Alexander J Muller, Judith F Baker, James B DuHadaway, Kai Ge, George Farmer, Arthur H Roach

Mol Cell Biol· June 2003

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Identification and characterization of presenilin-independent Notch signaling.
Bridget E Berechid, Magali Kitzmann, Daniel R Foltz, Arthur H Roach, Dietmar Seiffert

J Biol Chem· March 2002

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