Publications by authors named "Thomas Piers"

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Amelioration of signaling deficits underlying metabolic shortfall in TREM2 human iPSC-derived microglia.
Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pocock

FEBS J· April 2025

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Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease.
Kevin Fang, Ehsan Pishva, Thomas Piers, Steffen Scholpp

J Cell Sci· February 2025

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WNT7A-positive dendritic cytonemes control synaptogenesis in cortical neurons.
Thomas M Piers, Kevin Fang, Seema C Namboori, Corin Liddle, Sally Rogers

Development· December 2024

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Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia.
Charles Arber, Jackie M Casey, Samuel Crawford, Naiomi Rambarack, Umran Yaman, Thomas M Piers

Acta Neuropathol· November 2024

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Microglia produce the amyloidogenic ABri peptide in familial British dementia.
Charles Arber, Jackie M Casey, Samuel Crawford, Naiomi Rambarack, Umran Yaman, Thomas M Piers

bioRxiv· June 2023

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Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach

Glia· April 2023

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Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model.
Jingzhang Wei, Charles Arber, Selina Wray, John Hardy, Thomas M Piers

Glia· April 2023

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A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Naciye Magusali, Andrew C Graham, Thomas M Piers, Pantila Panichnantakul, Umran Yaman

Brain· December 2021

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Intracranial pressure monitoring in severe traumatic brain injury: Quo Vadis?
Jeffrey V Rosenfeld, Piers A W Thomas, Martin K Hunn

ANZ J Surg· December 2021

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Differential Stimulation of Pluripotent Stem Cell-Derived Human Microglia Leads to Exosomal Proteomic Changes Affecting Neurons.
Anna Mallach, Johan Gobom, Charles Arber, Thomas M Piers, John Hardy

Cells· October 2021

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Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.
Iqra Nazish, Charles Arber, Thomas M Piers, Thomas T Warner, John A Hardy

Neurochem Int· July 2021

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Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M Piers, James Staddon

Sci Rep· June 2021

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The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles.
Anna Mallach, Johan Gobom, Henrik Zetterberg, John Hardy, Thomas M Piers

Brain Commun· February 2021

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Management of Australian Patients with Severe Traumatic Brain Injury: Are Potentially Harmful Treatments Still Used?
Dashiell Gantner, Peter Bragge, Simon Finfer, Belinda Gabbe, Dinesh Varma, Piers Thomas

J Neurotrauma· December 2020

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Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.
Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Thomas M Piers

Hum Mol Genet· November 2020

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A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro

FASEB J· February 2020

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Growth and Resorption of Chronic Subdural Hematomas: Gardner, Weir, and the Osmotic Hypothesis Revisited.
Piers A W Thomas, Laurence A G Marshman, Donna Rudd, Claire Moffat, Paul S Mitchell

World Neurosurg· December 2019

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S-100β in chronic subdural haematoma: Prospective cohort study.
Piers A W Thomas, Claire E Moffatt, Donna Rudd, Laurence A G Marshman

J Clin Neurosci· September 2019

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Early Postoperative Morbidity After Chronic Subdural Hematoma: Predictive Usefulness of the Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity, American College of Surgeons National Surgical Quality Improvement Program, and American Society of Anesthesiologists Grade in a Prospective Cohort.
Piers A W Thomas, Paul S Mitchell, Laurence A G Marshman

World Neurosurg· April 2019

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Soluble Fibrinogen Triggers Non-cell Autonomous ER Stress-Mediated Microglial-Induced Neurotoxicity.
Thomas M Piers, Emma East, Claudio Villegas-Llerena, Ioanna G Sevastou, Mar Matarin

Front Cell Neurosci· November 2018

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The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Xianyuan Xiang, Thomas M Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach

Mol Neurodegener· September 2018

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Modelling microglial function with induced pluripotent stem cells: an update.
Jennifer M Pocock, Thomas M Piers

Nat Rev Neurosci· August 2018

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Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.
Pablo Garcia-Reitboeck, Alexandra Phillips, Thomas M Piers, Claudio Villegas-Llerena, Matt Butler

Cell Rep· August 2018

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Postsynaptic p47phox regulates long-term depression in the hippocampus.
Jee Hyun Yi, Dong Hyun Kim, Thomas M Piers, Seung Chan Kim, Daniel J Whitcomb

Cell Discov· August 2018

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Spontaneous resolution of a non-traumatic vertebro-vertebral arteriovenous fistula in a paediatric patient.
Paul Mitchell, Piers Thomas, David Anderson

J Clin Neurosci· July 2018

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