Publications by authors named "James Staddon"

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Advancing novel therapies for neurodegeneration through an innovative model for industry-academia collaborations: A decade of the Eisai-UCL experience.
Peter J Atkinson, Meera Swami, Nicola Ridgway, Malcolm Roberts, Jane Kinghorn, James M Staddon

Drug Discov Today· October 2023

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High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy.
Roberta Tufi, Emily H Clark, Tamaki Hoshikawa, Christiana Tsagkaraki, Jack Stanley, James M Staddon

SLAS Discov· April 2023

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Identification of pyrimidinyl piperazines as non-iminosugar glucocerebrosidase (GCase) pharmacological chaperones.
Tamaki Hoshikawa, Toru Watanabe, Makoto Kotake, Nathalie Tiberghien, Chi-Kit Woo, James M Staddon

Bioorg Med Chem Lett· February 2023

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Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches.
Eliona Tsefou, Alison S Walker, Emily H Clark, Amy R Hicks, Christin Luft, James M Staddon

Biochem J· December 2021

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Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome.
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M Piers, James Staddon

Sci Rep· June 2021

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Functional assessment of glucocerebrosidase modulator efficacy in primary patient-derived macrophages is essential for drug development and patient stratification.
Natalie J Welsh, Christina A Gewinner, Kavita Mistry, Mumta Koglin, Juniebel Cooke, James M Staddon

Haematologica· May 2020

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Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.
Malcolm Roberts, Ioanna Sevastou, Yoichi Imaizumi, Kavita Mistry, Sonia Talma, James M Staddon

Acta Neuropathol Commun· February 2020

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Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria.
Thomas Briston, Sian Lewis, Mumta Koglin, Kavita Mistry, Yongchun Shen, James M Staddon

Sci Rep· November 2016

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G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization.
Tatiana D Papkovskaia, Kai-Yin Chau, Francisco Inesta-Vaquera, Dmitri B Papkovsky, Daniel G Healy, James Staddon

Hum Mol Genet· October 2012

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Amphiphysin I phosphorylation on residue threonine 260 in a pentylenetetrazole-induced seizure model.
Mowdood Choudhury, Oliver Kleiner, Raymond Chung, Laura Barden, Louise Morgan, James M Staddon

Neurosci Lett· October 2008

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Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system.
Louise Morgan, Stephen J Neame, Hannah Child, Raymond Chung, Bina Shah, James M Staddon

Neurosci Lett· March 2006

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The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold.
Piotr P Graczyk, Afzal Khan, Gurpreet S Bhatia, Vanessa Palmer, Darren Medland, James M Staddon

Bioorg Med Chem Lett· November 2005

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Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase.
Jean-Cheng Kuo, Jia-Ren Lin, James M Staddon, Hiroshi Hosoya, Ruey-Hwa Chen

J Cell Sci· December 2003

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High-throughput methods to detect dimerization of Bcl-2 family proteins.
Jonathan Whitfield, Kokichi Harada, Catherine Bardelle, James M Staddon

Anal Biochem· November 2003

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Cytotoxic necrotizing factor 1 of Escherichia coli stimulates Rho/Rho-kinase-dependent myosin light-chain phosphorylation without inactivating myosin light-chain phosphatase in endothelial cells.
Markus Essler, Stefan Linder, Barbara Schell, Katharina Hüfner, Agnès Wiedemann, James M Staddon

Infect Immun· September 2003

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Occludin phosphorylation: identification of an occludin kinase in brain and cell extracts as CK2.
Caroline Smales, Moira Ellis, Rachel Baumber, Nayer Hussain, Howard Desmond, James M Staddon

FEBS Lett· June 2003

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Heme oxygenase modulates oxidant-signaled airway smooth muscle contractility: role of bilirubin.
Abdoulaye Samb, Camille Taillé, Abdelhamid Almolki, Jérôme Mégret, James M Staddon

Am J Physiol Lung Cell Mol Physiol· September 2002

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