Publications by authors named "Jaime Mella"

Claim this Profile
B
Benzo[]imidazole-Naphthalen-Arylmethanone Regioisomers as CB Ligands: Evaluation of Agonism via an Indirect Cytotoxicity-Based Approach.
Analia Young Hwa Cho, Renato Burgos Ravanal, Valeria Zuñiga Salazar, Marco Mellado, Marcos Lorca, Jaime Mella

Int J Mol Sci· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design of Hybrid Quinoline-Chalcone Compounds Against Based on Computational Techniques: 2D- and 3D-QSAR with Experimental Validation.
Marcos Lorca, Gisela C Muscia, Jaime Mella, Luciana Thomaz, Jenicer K Yokoyama-Yasunaka, Marco Mellado

Pharmaceuticals (Basel)· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Guided Discovery of Benzoic-Acid-Based TRPC6 Ligands: An Integrated Docking, MD, and MM-GBSA SAR Study: Potential Therapeutic Molecules for Autism Spectrum Disorder.
Nicolás Ignacio Silva, Gianfranco Sabadini, David Cabezas, Cristofer González, Paulina González, Marco Mellado, Jaime Mella

Pharmaceuticals (Basel)· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of Novel Chloro-Benzo []imidazole Regioisomers as Selective CB Receptor Agonists: Indirect Functional Evaluation and Molecular Insights.
Valeria Zuñiga Salazar, Renato Burgos Ravanal, Jonathan Soto-Flores, Gianfranco Sabadini, José Vicente González, Jaime Mella

Pharmaceuticals (Basel)· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Past and Present of the Antioxidant Studies in Chile: A Bibliometric Study from 2000 to 2024.
Marcos Lorca, Alejandro Vega-Muñoz, Alison Acosta, David Cabezas, Katy Díaz, Jaime Mella, Marco Mellado

Antioxidants (Basel)· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
3
3D-QSAR Design of New Bcr-Abl Inhibitors Based on Purine Scaffold and Cytotoxicity Studies on CML Cell Lines Sensitive and Resistant to Imatinib.
David Cabezas, Thalía Delgado, Guisselle Sepúlveda, Petra Krňávková, Veronika Vojáčková, Guido Mellado, Jaime Mella

Pharmaceuticals (Basel)· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
New Dimethoxyaryl-Sesquiterpene Derivatives with Cytotoxic Activity Against MCF-7 Breast Cancer Cells: From Synthesis to Topoisomerase I/II Inhibition and Cell Death Mechanism Studies.
Ileana Araque, Rut Vergara, Jaime Mella, Pablo Aránguiz, Luis Espinoza-Catalán

Int J Mol Sci· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
2
2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of : An In Silico Approach with Experimental Validation.
Marcos Lorca, Gisela C Muscia, Susana Pérez-Benavente, José M Bautista, Alison Acosta, Jaime Mella, Marco Mellado

Pharmaceuticals (Basel)· July 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Arylamines QSAR-Based Design and Molecular Dynamics of New Phenylthiophene and Benzimidazole Derivatives with Affinity for the C111, Y268, and H73 Sites of SARS-CoV-2 PLpro Enzyme.
Gianfranco Sabadini, Marco Mellado, César Morales, Jaime Mella

Pharmaceuticals (Basel)· May 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In silico approaches to develop new phenyl-pyrimidines as glycogen synthase kinase 3 (GSK-3) inhibitors with halogen-bonding capabilities: 3D-QSAR CoMFA/CoMSIA, molecular docking and molecular dynamics studies.
David Cabezas, Guido Mellado, Nicolás Espinoza, José Antonio Gárate, César Morales, Marco Mellado, Jaime Mella

J Biomol Struct Dyn· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
QSAR Studies, Synthesis, and Biological Evaluation of New Pyrimido-Isoquinolin-Quinone Derivatives against Methicillin-Resistant .
Juan Andrades-Lagos, Javier Campanini-Salinas, Gianfranco Sabadini, Victor Andrade, Jaime Mella

Pharmaceuticals (Basel)· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, Synthesis, and Structure-Activity Relationship Studies of New Quinone Derivatives as Antibacterial Agents.
Juan Andrades-Lagos, Javier Campanini-Salinas, América Pedreros-Riquelme, Jaime Mella, Duane Choquesillo-Lazarte

Antibiotics (Basel)· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol.
Ileana Araque, Javiera Ramírez, Rut Vergara, Jaime Mella, Pablo Aránguiz

Molecules· May 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives.
Marcos Lorca, David Cabezas, Ileana Araque, Andrés Terán, Santiago Hernández, Marco Mellado, Jaime Mella

Steroids· February 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
QSAR-driven synthesis of antiproliferative chalcones against SH-SY5Y cancer cells: Design, biological evaluation, and redesign.
Marco Mellado, Mauricio Reyna-Jeldes, Caroline Weinstein-Oppenheimer, Alejandra A Covarrubias, Luis F Aguilar, Jaime Mella

Arch Pharm (Weinheim)· July 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia.
Jeanluc Bertrand, Hana Dostálová, Vladimír Kryštof, Radek Jorda, Thalía Delgado, Jaime Mella

Pharmaceutics· June 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor.
Ulviye Acar Çevik, Ismail Celik, Jaime Mella, Marco Mellado, Yusuf Özkay

ACS Omega· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin  -6-Styrylcoumarin.
Marco Mellado, César González, Jaime Mella, Luis F Aguilar, Ismail Celik

Molecules· January 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors.
Marco Mellado, César González, Jaime Mella, Luis F Aguilar, Dolores Viña

Bioorg Chem· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, synthesis, antifungal activity, and structure-activity relationship studies of chalcones and hybrid dihydrochromane-chalcones.
Marco Mellado, Luis Espinoza, Alejandro Madrid, Jaime Mella, Eduardo Chávez-Weisser

Mol Divers· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
3
3-Arylcoumarins as highly potent and selective monoamine oxidase B inhibitors: Which chemical features matter?
Marco Mellado, Jaime Mella, César González, Dolores Viña, Eugenio Uriarte

Bioorg Chem· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia.
Jeanluc Bertrand, Hana Dostálová, Vladimir Krystof, Radek Jorda, Alejandro Castro, Jaime Mella

Bioorg Chem· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays.
Cristian O Salas, Ana Maria Zarate, Vladimir Kryštof, Jaime Mella, Mario Faundez

Int J Mol Sci· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands.
Marcos Lorca, Yudisladys Valdes, Hery Chung, Javier Romero-Parra, C David Pessoa-Mahana, Jaime Mella

Int J Mol Sci· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
State of the art of Smo antagonists for cancer therapy: advances in the target receptor and new ligand structures.
Christian Espinosa-Bustos, Jaime Mella, Jorge Soto-Delgado, Cristian O Salas

Future Med Chem· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis