Publications by authors named "James A Harker"

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T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease.
Faith I Uwadiae, Lucia Labeur-Iurman, Chloe J Pyle, Karim Boustani, Artur Gerasimov, James A Harker

Mucosal Immunol· October 2025

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Unravelling the interplay between respiratory disease and the immune landscape in long COVID.
James A Harker, Ryan S Thwaites

Nat Immunol· May 2025

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Autoimmunity in long COVID.
Shubha Talwar, James A Harker, Peter J M Openshaw, Ryan S Thwaites

J Allergy Clin Immunol· April 2025

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Mechanisms of antibody mediated immunity - Distinct in early life.
Lucia Labeur-Iurman, James A Harker

Int J Biochem Cell Biol· July 2024

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Role of epithelial barrier function in inducing type 2 immunity following early-life viral infection.
Kunyuan Tian, Prakrati Dangarh, Haina Zhang, Christian L Hines, Andrew Bush, James A Harker

Clin Exp Allergy· February 2024

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IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection.
James A Harker, Trever T Greene, Burton E Barnett, Phuc Bao, Aleksandr Dolgoter

Front Immunol· August 2023

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T helper 2 cells in asthma.
James A Harker, Clare M Lloyd

J Exp Med· June 2023

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Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma.
Chloe J Pyle, Dhiren F Patel, Teresa Peiró, Régis Joulia, Aleksander M Grabiec, James A Harker

Am J Respir Crit Care Med· December 2022

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Enhanced immune responses following heterologous vaccination with self-amplifying RNA and mRNA COVID-19 vaccines.
Tamara Elliott, Hannah M Cheeseman, Abbey B Evans, Suzanne Day, Leon R McFarlane, James A Harker

PLoS Pathog· October 2022

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Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects.
Romain Mary, Fanny Chalmin, Théo Accogli, Mélanie Bruchard, Christophe Hibos, James A Harker

Cancer Immunol Res· July 2022

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Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease.
Bavithra Vijayakumar, Karim Boustani, Patricia P Ogger, Artemis Papadaki, James Tonkin, James A Harker

Immunity· March 2022

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T Follicular Helper Cells in Asthma Through Murine Models of Allergic Airway Disease.
Faith I Uwadiae, James A Harker

Methods Mol Biol· January 2022

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Autoantibodies are present in the bronchoalveolar lavage but not circulation in patients with fibrotic interstitial lung disease.
Karim Boustani, Poonam Ghai, Rachele Invernizzi, Richard J Hewitt, Toby M Maher, James A Harker

ERJ Open Res· January 2022

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Enhanced IL-2 in early life limits the development of TFH and protective antiviral immunity.
Chloe J Pyle, Lucia Labeur-Iurman, Helen T Groves, Franz Puttur, Clare M Lloyd, James A Harker

J Exp Med· December 2021

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Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic Challenge.
Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi, John B G Mackey, James A Harker

Front Immunol· June 2021

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Overlapping and distinct features of viral and allergen immunity in the human lung.
James A Harker, Clare M Lloyd

Immunity· April 2021

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Rapidly Deployable Mouse Models of SARS-CoV-2 Infection Add Flexibility to the COVID-19 Toolbox.
James A Harker, Cecilia Johansson

Am J Respir Cell Mol Biol· January 2021

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A Not-So-Good Way to Die? Respiratory Syncytial Virus-induced Necroptotic Cell Death Promotes Inflammation and Type 2-mediated Pathology.
James A Harker, Robert J Snelgrove

Am J Respir Crit Care Med· June 2020

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Immunological fortification at our barrier organs: Protecting us as we age.
James A Harker, Laura J Pallett

Immunology· June 2020

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Enhanced frequency and function of follicular T cells in the tonsils of house dust mite-sensitized children.
William S Foster, Christopher J Grime, Hui-Leng Tan, Geoffrey S Williams, Matthew J Robinson, James A Harker

Allergy· May 2020

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Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration.
Mounia Beloueche-Babari, Teresa Casals Galobart, Teresa Delgado-Goni, Slawomir Wantuch, Harold G Parkes, James A Harker

Br J Cancer· March 2020

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T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection.
Kurt A Wong, James A Harker, Aleksandr Dolgoter, Nuha Marooki, Elina I Zuniga

J Immunol· September 2019

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Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.
Faith I Uwadiae, Chloe J Pyle, Simone A Walker, Clare M Lloyd, James A Harker

Allergy· April 2019

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Epigenetic Control of Interleukin-9 in Asthma.
Clare M Lloyd, James A Harker

N Engl J Med· July 2018

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C1q restrains autoimmunity and viral infection by regulating CD8 T cell metabolism.
Guang Sheng Ling, Greg Crawford, Norzawani Buang, Istvan Bartok, Kunyuan Tian, James A Harker

Science· May 2018

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