Publications by authors named "Simone A Walker"

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Severe asthma is characterized by a sex-specific ILC landscape and aberrant airway profile that is suppressed by anti-IL-5/5Rα biologics.
Kyle T Mincham, Lola E Loewenthal, Garance F M Meyer, Sara Fontanella, Martina Marfia, Simone A Walker

Sci Transl Med· October 2025

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T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease.
Faith I Uwadiae, Lucia Labeur-Iurman, Chloe J Pyle, Karim Boustani, Artur Gerasimov, Simone A Walker

Mucosal Immunol· October 2025

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Protective Role for Itaconate During Inhaled Allergen Challenge.
Gesa J Albers, Patricia P Ogger, Christina Michalaki, Helen Stölting, Simone A Walker

Allergy· October 2025

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Epithelial cell derived lumican modulates extracellular matrix dynamics in early-life airways disease.
Franz Puttur, William J Traves, Minerva G Martin, Samuele Di Carmine, Frédéric Fercoq, Simone A Walker

J Allergy Clin Immunol· September 2025

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A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma.
Régis Joulia, Sara Patti, William J Traves, Lola Loewenthal, Laura Yates, Simone A Walker

Nat Immunol· June 2025

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The respiratory microbiome in patients with post-COVID-19 residual lung abnormalities resembles that of healthy individuals and is distinct from idiopathic pulmonary fibrosis.
David J F Smith, Nancy M Y Teng, Emma K Denneny, Puja Mehta, Stefan C Stanel, Simone A Walker

ERJ Open Res· May 2025

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Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen.
Gesa J Albers, Christina Michalaki, Patricia P Ogger, Amy F Lloyd, Benjamin Causton, Simone A Walker

Mucosal Immunol· February 2025

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3D printed hybrid scaffolds do not induce adverse inflammation in mice and direct human BM-MSC chondrogenesis .
Silvia A Ferreira, Francesca Tallia, Agathe Heyraud, Simone A Walker, Christoph Salzlechner

Biomater Biosyst· March 2024

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Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma.
Régis Joulia, Franz Puttur, Helen Stölting, William J Traves, Lewis J Entwistle, Simone A Walker

J Clin Invest· March 2024

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Lung extracellular matrix modulates KRT5 basal cell activity in pulmonary fibrosis.
Richard J Hewitt, Franz Puttur, David C A Gaboriau, Frédéric Fercoq, Maryline Fresquet, Simone A Walker

Nat Commun· September 2023

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Experimental Mouse Models of Asthma and Analysis of CD4 T Cells.
William J Branchett, Simone A Walker, Clare M Lloyd

Methods Mol Biol· June 2021

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Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure.
William J Branchett, James Cook, Robert A Oliver, Nicoletta Bruno, Simone A Walker

J Allergy Clin Immunol· May 2021

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Itaconate controls the severity of pulmonary fibrosis.
Patricia P Ogger, Gesa J Albers, Richard J Hewitt, Brendan J O'Sullivan, Joseph E Powell, Simone A Walker

Sci Immunol· October 2020

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Dynamics of human monocytes and airway macrophages during healthy aging and after transplant.
Adam J Byrne, Joseph E Powell, Brendan J O'Sullivan, Patricia P Ogger, Ashley Hoffland, Simone A Walker

J Exp Med· March 2020

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A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma.
William J Branchett, Helen Stölting, Robert A Oliver, Simone A Walker, Franz Puttur

J Allergy Clin Immunol· February 2020

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Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation.
Dhiren F Patel, Teresa Peiró, Nicoletta Bruno, Juho Vuononvirta, Samia Akthar, Simone A Walker

Sci Immunol· November 2019

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The Transferrin Receptor CD71 Delineates Functionally Distinct Airway Macrophage Subsets during Idiopathic Pulmonary Fibrosis.
Sarah J Allden, Patricia P Ogger, Poonam Ghai, Peter McErlean, Richard Hewitt, Simone A Walker

Am J Respir Crit Care Med· July 2019

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Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans.
Franz Puttur, Laura Denney, Lisa G Gregory, Juho Vuononvirta, Robert Oliver, Simone A Walker

Sci Immunol· June 2019

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Targeting the ICOS/ICOS-L pathway in a mouse model of established allergic asthma disrupts T follicular helper cell responses and ameliorates disease.
Faith I Uwadiae, Chloe J Pyle, Simone A Walker, Clare M Lloyd, James A Harker

Allergy· April 2019

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Lung Defense through IL-8 Carries a Cost of Chronic Lung Remodeling and Impaired Function.
Catherine J Reynolds, Kathryn Quigley, Xiaoming Cheng, Apurva Suresh, Sundas Tahir, Simone Alexandra Walker

Am J Respir Cell Mol Biol· November 2018

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Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13CD4 T cells.
Sejal Saglani, Lisa G Gregory, Avneet K Manghera, William J Branchett, Faith Uwadiae, Simone A Walker

Sci Immunol· September 2018

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An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Dhiren F Patel, Teresa Peiró, Amelia Shoemark, Samia Akthar, Simone A Walker

Sci Transl Med· August 2018

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Manipulation of dipeptidylpeptidase 10 in mouse and human and models indicates a protective role in asthma.
Youming Zhang, Thanushiyan Poobalasingam, Laura L Yates, Simone A Walker, Martin S Taylor

Dis Model Mech· January 2018

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Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.
Stephan Löser, Lisa G Gregory, Youming Zhang, Katrein Schaefer, Simone A Walker

J Allergy Clin Immunol· May 2017

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Heterozygous mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.
Thanushiyan Poobalasingam, Laura L Yates, Simone A Walker, Miguel Pereira, Nina Y Gross

Dis Model Mech· April 2017

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