Publications by authors named "James B Stewart"

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An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice.
Eloïse Marques, Stephen P Burr, Alva M Casey, Richard J Stopforth, Chak Shun Yu, James B Stewart

Nat Commun· November 2025

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Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations.
Michele Frison, Brandon S Lockey, Yu Nie, Zoe Golder, Eleni Theiaspra, James B Stewart

Science· October 2025

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Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.
Güleycan Lutfullahoglu Bal, Kah Ying Ng, Eli Berzell, Ani Akpinar, Alex E Ekvik, James B Stewart

bioRxiv· October 2025

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Correcting a pathogenic mitochondrial DNA mutation by base editing in mice.
Jose D Barrera-Paez, Sandra R Bacman, Till Balla, Derek Van Booven, Durga P Gannamedi, James B Stewart

Sci Transl Med· January 2025

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Mechanisms and pathologies of human mitochondrial DNA replication and deletion formation.
Tiago M Bernardino Gomes, Amy E Vincent, Katja E Menger, James B Stewart, Thomas J Nicholls

Biochem J· June 2024

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mitoTALEN reduces the mutant mtDNA load in neurons.
Sandra R Bacman, Jose Domingo Barrera-Paez, Milena Pinto, Derek Van Booven, James B Stewart

Mol Ther Nucleic Acids· March 2024

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Cultured lymphocytes' mitochondrial genome integrity is not altered by cladribine.
Elina Järvinen, Fumi Suomi, James B Stewart, Dimitri Guala, Miko Valori

Clin Exp Immunol· December 2023

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High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life.
Angelos Glynos, Lyuba V Bozhilova, Michele Frison, Stephen Burr, James B Stewart

Sci Adv· October 2023

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Cell lineage-specific mitochondrial resilience during mammalian organogenesis.
Stephen P Burr, Florian Klimm, Angelos Glynos, Malwina Prater, Pamella Sendon, James B Stewart

Cell· March 2023

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Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function.
Viraj Muthye, Cameron D Mackereth, James B Stewart, Dennis V Lavrov

DNA Repair (Amst)· February 2022

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Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission.
Haixin Zhang, Marco Esposito, Mikael G Pezet, Juvid Aryaman, Wei Wei, James B Stewart

Sci Adv· December 2021

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Characterization of E-cigarette coil temperature and toxic metal analysis by infrared temperature sensing and scanning electron microscopy - energy-dispersive X-ray.
Haley A Mulder, James B Stewart, Ivy P Blue, Rose I Krakowiak, Jesse L Patterson

Inhal Toxicol· April 2021

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Current progress with mammalian models of mitochondrial DNA disease.
James Bruce Stewart

J Inherit Metab Dis· March 2021

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High-Throughput Detection of mtDNA Mutations Leading to tRNA Processing Errors.
Marita Annika Isokallio, James Bruce Stewart

Methods Mol Biol· March 2021

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Extreme heterogeneity of human mitochondrial DNA from organelles to populations.
James B Stewart, Patrick F Chinnery

Nat Rev Genet· February 2021

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Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing.
Swaraj Basu, Xie Xie, Jay P Uhler, Carola Hedberg-Oldfors, Dusanka Milenkovic, James B Stewart

PLoS Genet· December 2020

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Delivery of mtZFNs into Early Mouse Embryos.
Beverly J McCann, Andy Cox, Payam A Gammage, James B Stewart, Magdalena Zernicka-Goetz

Methods Mol Biol· July 2019

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Mitochondrial stress response triggered by defects in protein synthesis quality control.
Uwe Richter, Kah Ying Ng, Fumi Suomi, Paula Marttinen, Taina Turunen, James B Stewart

Life Sci Alliance· February 2019

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Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNA levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, James B Stewart

Nat Med· December 2018

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Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.
Payam A Gammage, Carlo Viscomi, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, James B Stewart

Nat Med· November 2018

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MitoTALEN reduces mutant mtDNA load and restores tRNA levels in a mouse model of heteroplasmic mtDNA mutation.
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, James B Stewart

Nat Med· November 2018

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A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.
Marie-Lune Simard, Arnaud Mourier, Laura C Greaves, Robert W Taylor, James B Stewart

J Pathol· July 2018

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Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.
Johanna H K Kauppila, Nina A Bonekamp, Arnaud Mourier, Marita A Isokallio, Alexandra Just, James B Stewart

Nucleic Acids Res· July 2018

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Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Stanka Matic, Min Jiang, Thomas J Nicholls, Jay P Uhler, Caren Dirksen-Schwanenland, James B Stewart

Nat Commun· March 2018

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Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load.
Min Jiang, Timo Eino Sakari Kauppila, Elisa Motori, Xinping Li, Ilian Atanassov, James Bruce Stewart

Cell Metab· August 2017

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