Publications by authors named "James D Dunbar"

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The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.
Kyle W Sloop, Amy L Cox, David B Wainscott, Alex White, Brian A Droz, James D Dunbar

Sci Transl Med· December 2024

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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist.
Olivier Benichou, Tamer Coskun, Malgorzata D Gonciarz, Parag Garhyan, Andrew C Adams, James D Dunbar

Cell Metab· February 2023

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Structural determinants of dual incretin receptor agonism by tirzepatide.
Bingfa Sun, Francis S Willard, Dan Feng, Jorge Alsina-Fernandez, Qi Chen, James D Dunbar

Proc Natl Acad Sci U S A· March 2022

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The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, James D Dunbar

Elife· July 2020

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Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice.
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar

Endocrinology· October 2017

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.
Alexei Kharitonenkov, John M Beals, Radmila Micanovic, Beth A Strifler, Radhakrishnan Rathnachalam, James D Dunbar

PLoS One· December 2013

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Fundamentals of FGF19 & FGF21 action in vitro and in vivo.
Andrew C Adams, Tamer Coskun, Armando R Irizarry Rovira, Michael A Schneider, David W Raches, James D Dunbar

PLoS One· September 2012

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FGF21 as a therapeutic reagent.
Yang Zhao, James D Dunbar, Alexei Kharitonenkov

Adv Exp Med Biol· April 2012

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Different roles of N- and C- termini in the functional activity of FGF21.
Radmila Micanovic, David W Raches, James D Dunbar, David A Driver, Holly A Bina

J Cell Physiol· May 2009

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Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.
Roxana Pincheira, Melinda Baerwald, James D Dunbar, David B Donner

EMBO J· February 2009

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Fibroblast growth factor 21 corrects obesity in mice.
Tamer Coskun, Holly A Bina, Michael A Schneider, James D Dunbar, Charlie C Hu

Endocrinology· December 2008

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FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity.
Peter Arner, Amanda Pettersson, Pamela J Mitchell, James D Dunbar, Alexei Kharitonenkov

FEBS Lett· May 2008

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FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho.
Alexei Kharitonenkov, James D Dunbar, Holly A Bina, Stuart Bright, Julie S Moyers

J Cell Physiol· April 2008

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Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling.
Julie S Moyers, Tatiyana L Shiyanova, Farrokh Mehrbod, James D Dunbar, Timothy W Noblitt

J Cell Physiol· January 2007

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Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.
Gretchen A LaRusch, Mark W Jackson, James D Dunbar, Robert S Warren, David B Donner

Cancer Res· January 2007

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