Publications by authors named "James D Winkler"

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Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors.
Jennifer R Diamond, Todd M Pitts, Dana Ungermannova, Christopher G Nasveschuk, Gan Zhang, James D Winkler

Mol Cancer Ther· March 2022

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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
Andrew P Crew, Kanak Raina, Hanqing Dong, Yimin Qian, Jing Wang, James D Winkler

J Med Chem· January 2018

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The Tolerome: A Database of Transcriptome-Level Contributions to Diverse Escherichia coli Resistance and Tolerance Phenotypes.
Keesha E Erickson, James D Winkler, Danh T Nguyen, Ryan T Gill, Anushree Chatterjee

ACS Synth Biol· December 2017

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Refactoring the Genetic Code for Increased Evolvability.
Gur Pines, James D Winkler, Assaf Pines, Ryan T Gill

mBio· November 2017

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Targeted protein degradation by PROTACs.
Taavi K Neklesa, James D Winkler, Craig M Crews

Pharmacol Ther· June 2017

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Quantifying complexity in metabolic engineering using the LASER database.
James D Winkler, Andrea L Halweg-Edwards, Ryan T Gill

Metab Eng Commun· December 2016

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The Resistome: A Comprehensive Database of Escherichia coli Resistance Phenotypes.
James D Winkler, Andrea L Halweg-Edwards, Keesha E Erickson, Alaksh Choudhury, Gur Pines

ACS Synth Biol· December 2016

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A Web Interface for Codon Compression.
Andrea L Halweg-Edwards, Gur Pines, James D Winkler, Assaf Pines, Ryan T Gill

ACS Synth Biol· September 2016

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer.
Kanak Raina, Jing Lu, Yimin Qian, Martha Altieri, Deborah Gordon, James D Winkler

Proc Natl Acad Sci U S A· June 2016

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The LASER database: Formalizing design rules for metabolic engineering.
James D Winkler, Andrea L Halweg-Edwards, Ryan T Gill

Metab Eng Commun· December 2015

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Complex systems in metabolic engineering.
James D Winkler, Keesha Erickson, Alaksh Choudhury, Andrea L Halweg-Edwards, Ryan T Gill

Curr Opin Biotechnol· December 2015

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Bacterial Recombineering: Genome Engineering via Phage-Based Homologous Recombination.
Gur Pines, Emily F Freed, James D Winkler, Ryan T Gill

ACS Synth Biol· November 2015

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Genome-Wide Tuning of Protein Expression Levels to Rapidly Engineer Microbial Traits.
Emily F Freed, James D Winkler, Sophie J Weiss, Andrew D Garst, Vivek K Mutalik

ACS Synth Biol· November 2015

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The emergence of commodity-scale genetic manipulation.
Andrea L Halweg-Edwards, William C Grau, James D Winkler, Andrew D Garst, Ryan T Gill

Curr Opin Chem Biol· October 2015

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
Jing Lu, Yimin Qian, Martha Altieri, Hanqing Dong, Jing Wang, James D Winkler

Chem Biol· June 2015

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Recent advances in the evolutionary engineering of industrial biocatalysts.
James D Winkler, Katy C Kao

Genomics· December 2014

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Evolved osmotolerant Escherichia coli mutants frequently exhibit defective N-acetylglucosamine catabolism and point mutations in cell shape-regulating protein MreB.
James D Winkler, Carlos Garcia, Michelle Olson, Emily Callaway, Katy C Kao

Appl Environ Microbiol· June 2014

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Clinical experience of MEK inhibitors in cancer therapy.
Ding Wang, Scott A Boerner, James D Winkler, Patricia M LoRusso

Biochim Biophys Acta· August 2007

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Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor.
Tammie C Yeh, Vivienne Marsh, Bryan A Bernat, Josh Ballard, Heidi Colwell, James D Winkler

Clin Cancer Res· March 2007

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4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
Lara S Kallander, Qing Lu, Wenfang Chen, Thaddeus Tomaszek, Guang Yang, James D Winkler

J Med Chem· September 2005

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Progress towards therapeutic small molecule MEK inhibitors for use in cancer therapy.
Eli M Wallace, Joseph P Lyssikatos, Tammie Yeh, James D Winkler, Kevin Koch

Curr Top Med Chem· June 2005

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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells.
Zunxuan Chen, Steven Clark, Marian Birkeland, Chiu Mei Sung, Amparo Lago, James D Winkler

Cancer Lett· December 2002

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Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.
Boyd B Scott, Paola F Zaratin, Antonio Colombo, Michael J Hansbury, James D Winkler

J Rheumatol· February 2002

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