Publications by authors named "James Lechleiter"

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-hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model.
Deborah M Holstein, Afaf Saliba, Damian Lozano, Jiwan Kim, Kumar Sharma, James D Lechleiter

J Cereb Blood Flow Metab· August 2025

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Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia.
July Carolina Romero, Sonal S Tonapi, Manish Parihar, Eva Loranc, Henry E Miller, James D Lechleiter

Nat Commun· June 2025

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Quinolinic acid potentially links kidney injury to brain toxicity.
Afaf Saliba, Subrata Debnath, Ian Tamayo, Hak Joo Lee, Nagarjunachary Ragi, James D Lechleiter

JCI Insight· February 2025

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β-Hydroxybutyrate enhances brain metabolism in normoglycemia and hyperglycemia, providing cerebroprotection in a mouse stroke model.
Deborah M Holstein, Afaf Saliba, Damian Lozano, Jiwan Kim, Kumar Sharma, James D Lechleiter

bioRxiv· February 2025

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HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS.
Chaoying Qin, Shasha Gong, Ting Liang, Zhenbo Zhang, Jessie Thomas, James Lechleiter

Adv Sci (Weinh)· December 2024

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Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease.
Qiang Chen, Luis Aguirre, Guoming Liang, Huanhuan Zhao, Tao Dong, James D Lechleiter

Mol Neurodegener· August 2024

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Lack of Interactions Between Alteplase/Tenecteplase and the Adenosine A1R/A3R Agonist AST-004.
Theodore E Liston, Deborah Holstein, Derek Solt, Damian Lozano, William S Korinek, James D Lechleiter

Stroke· July 2024

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Quinolinic acid links kidney injury to brain toxicity.
Afaf Saliba, Subrata Debnath, Ian Tamayo, Jana Tumova, Meyer Maddox, James D Lechleiter

bioRxiv· May 2024

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Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease.
Qiang Chen, Luis Aguirre, Huanhuan Zhao, Felix Borrego, Itziar de Rojas, James D Lechleiter

medRxiv· October 2023

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Acute Treatment with the M-Channel (K7, KCNQ) Opener Retigabine Reduces the Long-Term Effects of Repetitive Blast Traumatic Brain Injuries.
Fabio A Vigil, Hindiael Belchior, Vladislav Bugay, Isabella I Bazaldua, Aiola Stoja, James D Lechleiter

Neurotherapeutics· April 2023

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Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke.
Elizabeth S Fisher, Yanan Chen, Mikaela M Sifuentes, Jeremy J Stubblefield, Damian Lozano, James D Lechleiter

Front Stroke· November 2022

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Ca signalling system initiated by endoplasmic reticulum stress stimulates PERK activation.
Constanza Feliziani, Macarena Fernandez, Gonzalo Quassollo, Deborah Holstein, Sebastián M Bairo, James D Lechleiter

Cell Calcium· September 2022

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HspB1 Overexpression Improves Life Span and Stress Resistance in an Invertebrate Model.
Courtney Carroll Alexander, Erin Munkáscy, Haven Tillmon, Tamara Fraker, Jessica Scheirer, James D Lechleiter

J Gerontol A Biol Sci Med Sci· February 2022

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Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke.
Theodore E Liston, Aldric Hama, Johannes Boltze, Russell B Poe, Takahiro Natsume, James D Lechleiter

Stroke· January 2022

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San Antonio Nathan Shock Center: your one-stop shop for aging research.
Adam B Salmon, James F Nelson, Jonathan A L Gelfond, Martin Javors, Brett Ginsburg, James Lechleiter

Geroscience· October 2021

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Neuroprotective Roles of the Adenosine A Receptor Agonist AST-004 in Mouse Model of Traumatic Brain Injury.
Eda Bozdemir, Fabio A Vigil, Sang H Chun, Liliana Espinoza, Vladislav Bugay, James D Lechleiter

Neurotherapeutics· October 2021

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Nucleotide P2Y receptor agonists are in vitro and in vivo prodrugs of A/A adenosine receptor agonists: implications for roles of P2Y and A/A receptors in physiology and pathology.
Theodore E Liston, Sonja Hinz, Christa E Müller, Deborah M Holstein, Jay Wendling, James D Lechleiter

Purinergic Signal· December 2020

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Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, "M-type") K currents in neurons.
Fabio A Vigil, Eda Bozdemir, Vladislav Bugay, Sang H Chun, MaryAnn Hobbs, James D Lechleiter

J Cereb Blood Flow Metab· June 2020

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A Mouse Model of Repetitive Blast Traumatic Brain Injury Reveals Post-Trauma Seizures and Increased Neuronal Excitability.
Vladislav Bugay, Eda Bozdemir, Fabio A Vigil, Sang H Chun, Deborah M Holstein, James D Lechleiter

J Neurotrauma· January 2020

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Time to Target Stroke: Examining the Circadian System in Stroke.
Jeremy J Stubblefield, James D Lechleiter

Yale J Biol Med· June 2019

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Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation.
Mikaela M Sifuentes, James D Lechleiter

Vitam Horm· October 2018

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The long-term effect of maternal dietary protein restriction on 5-HT receptor function and behavioral responses to stress in adulthood.
Wenrui Ye, Michael Duffy Pitlock, Martin A Javors, Brent J Thompson, James D Lechleiter

Behav Brain Res· September 2018

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Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
Candice E Van Skike, Jordan B Jahrling, Angela B Olson, Naomi L Sayre, Stacy A Hussong, James D Lechleiter

Am J Physiol Heart Circ Physiol· April 2018

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Cyclophilin D over-expression increases mitochondrial complex III activity and accelerates supercomplex formation.
Julie C Etzler, Mariana Bollo, Deborah Holstein, Janice Jianhong Deng, Viviana Perez, James D Lechleiter

Arch Biochem Biophys· January 2017

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Calcineurin β protects brain after injury by activating the unfolded protein response.
Yanan Chen, Deborah M Holstein, Sofia Aime, Mariana Bollo, James D Lechleiter

Neurobiol Dis· October 2016

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