Publications by authors named "James Mangold"

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Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.
Heidi J Einolf, Wen Lin, Christina S Won, Lai Wang, Helen Gu, James B Mangold

Drug Metab Dispos· December 2017

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Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
Jimmy Flarakos, Yancy Du, Helen Gu, Lai Wang, Heidi J Einolf, James B Mangold

Xenobiotica· August 2017

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Pharmacokinetics, Distribution, Metabolism, and Excretion of Omadacycline following a Single Intravenous or Oral Dose of 14C-Omadacycline in Rats.
Wen Lin, Jimmy Flarakos, Yancy Du, Wenyu Hu, Handan He, James Mangold

Antimicrob Agents Chemother· January 2017

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Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.
Jimmy Flarakos, Yancy Du, Timothy Bedman, Qusai Al-Share, Pierre Jordaan, James B Mangold

Xenobiotica· November 2016

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Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent.
Su-Er W Huskey, Ry R Forseth, Hongmei Li, Zhigang Jian, Alexandre Catoire, James B Mangold

Drug Metab Dispos· October 2016

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Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4β-Hydroxycholesterol and Changes in Midazolam Exposure.
James B Mangold, Fan Wu, Sam Rebello

Clin Pharmacol Drug Dev· July 2016

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Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Su-Er W Huskey, Chun-qi Zhu, Melissa M Lin, Ry R Forseth, Helen Gu, James B Mangold

Drug Metab Dispos· May 2016

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KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects.
Su-Er W Huskey, Chun-qi Zhu, Andreas Fredenhagen, Jürgen Kühnöl, Alexandre Luneau, James B Mangold

Drug Metab Dispos· May 2016

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Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.
Binfeng Xia, Avantika Barve, Tycho Heimbach, Tao Zhang, Helen Gu, James B Mangold

Eur J Pharm Sci· October 2014

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An industry perspective on tiered approach to the investigation of metabolites in drug development.
Su-Er W Huskey, Wenkui Li, James B Mangold, Jimmy Flarakos

Bioanalysis· March 2014

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Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects.
Shyeilla Dhuria, Heidi Einolf, James Mangold, Suman Sen, Helen Gu

J Clin Pharmacol· June 2013

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Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species.
Upendra A Argikar, James B Mangold, Shawn P Harriman

Curr Top Med Chem· July 2011

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Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.
Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, James B Mangold

Drug Metab Dispos· March 2009

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Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor.
Christiane M Rordorf, Les Choi, Paul Marshall, James B Mangold

Clin Pharmacokinet· August 2006

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Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.
James B Mangold, Helen Gu, Lolita C Rodriguez, Johanne Bonner, Janet Dickson

Drug Metab Dispos· May 2004

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N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
Corinne J Hackbarth, Dawn Z Chen, Jason G Lewis, Kirk Clark, James B Mangold

Antimicrob Agents Chemother· September 2002

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