Publications by authors named "James Neels"

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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.
Zhonghui Lu, James J-W Duan, Haiyun Xiao, James Neels, Dauh-Rurng Wu

Bioorg Med Chem Lett· August 2019

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PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.
Jon J Hangeland, Lynn M Abell, Leonard P Adam, Ji Jiang, Todd J Friends, James Neels

ACS Med Chem Lett· July 2018

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Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
Qingjie Liu, Qing Shi, David Marcoux, Douglas G Batt, Lyndon Cornelius, James Neels

J Med Chem· June 2017

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Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Lan-Ying Qin, Zheming Ruan, Robert J Cherney, T G Murali Dhar, James Neels

Bioorg Med Chem Lett· February 2017

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Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
Rajeev S Bhide, James Neels, Lan-Ying Qin, Zheming Ruan, Sylwia Stachura

Bioorg Med Chem Lett· September 2016

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Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor.
Heather J Finlay, James A Johnson, John L Lloyd, Ji Jiang, James Neels

ACS Med Chem Lett· September 2016

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Pseudosaccharin amines as potent and selective KV1.5 blockers.
John Lloyd, Heather J Finlay, Alexander Kover, James Johnson, Zulan Pi, James Neels

Bioorg Med Chem Lett· November 2015

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Chemical and enzymatic reductive activation of acylfulvene to isomeric cytotoxic reactive intermediates.
Kathryn E Pietsch, James F Neels, Xiang Yu, Jiachang Gong, Shana J Sturla

Chem Res Toxicol· November 2011

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Quantitative correlation of drug bioactivation and deoxyadenosine alkylation by acylfulvene.
James F Neels, Jiachang Gong, Xiang Yu, Shana J Sturla

Chem Res Toxicol· October 2007

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Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
Jiachang Gong, James F Neels, Xiang Yu, Thomas W Kensler, Lisa A Peterson

J Med Chem· April 2006

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