Publications by authors named "James Purcell"

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Factors associated with increased risk of postoperative blood transfusion in patients undergoing total hip arthroplasty at an Irish University Hospital.
Gavin David O'Connor, Stephen Mannion, James Purcell

Ir J Med Sci· August 2024

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ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies.
Chewei Anderson Chang, Ethan Emberley, Aloma L D'Souza, Weilong Zhao, Cormac Cosgrove, James W Purcell

Blood· August 2024

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Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-β Signaling.
Tsz Lam Matthew Wong, Tin-Lok Wong, Lei Zhou, Kwan Man, James Purcell

Cell Mol Gastroenterol Hepatol· December 2022

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Exploiting LRRC15 as a Novel Therapeutic Target in Cancer.
Upasana Ray, Christopher L Pathoulas, Prabhu Thirusangu, James W Purcell, Nagarajan Kannan

Cancer Res· May 2022

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Targeting LRRC15 Inhibits Metastatic Dissemination of Ovarian Cancer.
Upasana Ray, Deok-Beom Jung, Ling Jin, Yinan Xiao, Subramanyam Dasari, James W Purcell

Cancer Res· March 2022

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Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm.
Kimihiko Yokosuka, Caleb Rutledge, Yoshinobu Kamio, Atsushi Kuwabara, Hiroki Sato, James Purcell

Stroke· August 2021

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First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors.
George D Demetri, Jason J Luke, Antoine Hollebecque, John D Powderly, Alexander I Spira, James W Purcell

Clin Cancer Res· July 2021

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Neutrophil Extracellular Traps Promote the Development of Intracranial Aneurysm Rupture.
Masaaki Korai, James Purcell, Yoshinobu Kamio, Kazuha Mitsui, Hajime Furukawa

Hypertension· June 2021

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LRRC15 antibody-drug conjugates show promise as osteosarcoma therapeutics in preclinical studies.
Katherine K Slemmons, Sanjit Mukherjee, Paul Meltzer, James W Purcell, Lee J Helman

Pediatr Blood Cancer· February 2021

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Design, Synthesis, and Biological Investigation of Thailanstatin A and Spliceostatin D Analogues Containing Tetrahydropyran, Tetrahydrooxazine, and Fluorinated Structural Motifs.
K C Nicolaou, Santhosh Reddy Rekula, S Mothish Kumar, Ananda Rao Podilapu, Ryan P Matuszak, James W Purcell

J Org Chem· February 2021

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Design, Synthesis, and Biological Evaluation of Tubulysin Analogues, Linker-Drugs, and Antibody-Drug Conjugates, Insights into Structure-Activity Relationships, and Tubulysin-Tubulin Binding Derived from X-ray Crystallographic Analysis.
K C Nicolaou, Saiyong Pan, Kiran K Pulukuri, Qiuji Ye, Stephan Rigol, James W Purcell

J Org Chem· February 2021

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Evaluation of PNU-159682 antibody drug conjugates (ADCs).
Dane Holte, Joseph P Lyssikatos, Amanda M Valdiosera, Zachary Swinney, Vikram Sisodiya, James W Purcell

Bioorg Med Chem Lett· December 2020

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Streamlined Symmetrical Total Synthesis of Disorazole B and Design, Synthesis, and Biological Investigation of Disorazole Analogues.
K C Nicolaou, Johannes Krieger, Ganesh M Murhade, Parthasarathi Subramanian, Balu D Dherange, James W Purcell

J Am Chem Soc· September 2020

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Geographic variation in incubation behavior of a widely distributed passerine bird.
Vanya G Rohwer, James R Purcell

PLoS One· March 2020

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LRRC15 Targeting in Soft-Tissue Sarcomas: Biological and Clinical Implications.
Eytan Ben-Ami, Raul Perret, Ying Huang, Félicie Courgeon, Prafulla C Gokhale, James Purcell

Cancers (Basel)· March 2020

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LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates.
James W Purcell, Sonia G Tanlimco, Jonathan Hickson, Melvin Fox, Mien Sho

Cancer Res· July 2018

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NF-κB is a critical mediator of BRCA1-induced chemoresistance.
Mary T Harte, Julia J Gorski, Kienan I Savage, James W Purcell, Eliana M Barros

Oncogene· February 2014

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Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR.
James W Purcell, Han K Kim, Sonia G Tanlimco, Minhtam Doan, Melvin Fox

Front Immunol· January 2014

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Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer.
James W Purcell, Jefferson Davis, Mamatha Reddy, Shamra Martin, Kimberly Samayoa

Clin Cancer Res· January 2010

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Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells.
Jennifer L Gilbert, James Purcell, Padraig Strappe, Matthew McCabe, Timothy O'Brien

Anticancer Drugs· September 2008

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BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs.
Niamh E Buckley, Alison M Hosey, Julia J Gorski, James W Purcell, Jude M Mulligan

Mol Cancer Res· March 2007

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STAT1: a modulator of chemotherapy-induced apoptosis.
Michelle Thomas, Clodagh E Finnegan, Katherine M-A Rogers, James W Purcell, Anne Trimble

Cancer Res· November 2004

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Complete interatrial block revisited.
James J Purcell

Chest· September 2002

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