Publications by authors named "James Rottman"

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Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency.
Philip M Zakas, Sharon C Cunningham, Ann Doherty, Eva B van Dijk, Raed Ibraheim, James B Rottman

Mol Ther· October 2024

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B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates.
James Kaminski, Ryan A Fleming, Francesca Alvarez-Calderon, Marlana B Winschel, Connor McGuckin, James B Rottman

Blood· July 2024

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T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice.
Olmo Sonzogni, Daniel E Zak, Maria Stella Sasso, Rochelle Lear, Alice Muntzer, James B Rottman

Oncoimmunology· April 2022

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Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers.
Samuel J Klempner, Johanna C Bendell, Victoria Meucci Villaflor, Laura LaNiel Tenner, Stacey M Stein, James B Rottman

Mol Cancer Ther· November 2021

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Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors.
Charles Caldwell, James B Rottman, Will Paces, Elizabeth Bueche, Sofia Reitsma

Sci Rep· May 2021

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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment.
Michael S Haas, Michael H Kagey, Heidi Heath, Franziska Schuerpf, James B Rottman

Mol Cancer Res· April 2021

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Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability.
Edward M Kennedy, Terry Farkaly, Peter Grzesik, Jennifer Lee, Agnieszka Denslow, James B Rottman

Mol Ther Oncolytics· September 2020

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Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease.
Matthew M Hsieh, Melissa Bonner, Francis John Pierciey, Naoya Uchida, James Rottman

Blood Adv· May 2020

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Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Elizabeth A Killion, Jinghong Wang, Junming Yie, Stone D-H Shi, Darren Bates, James B Rottman

Sci Transl Med· December 2018

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Novel protein therapeutic joint retention strategy based on collagen-binding Avimers.
Joanne T Hulme, Warren N D'Souza, Helen J McBride, Bo-Rin Park Yoon, Angela M Willee, James B Rottman

J Orthop Res· April 2018

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A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refractory solid tumors.
Maxim Kebenko, Marie-Elisabeth Goebeler, Martin Wolf, Annette Hasenburg, Ruth Seggewiss-Bernhardt, James B Rottman

Oncoimmunology· April 2018

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Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction.
Sandra L Ross, Kaustav Biswas, James Rottman, Jennifer R Allen, Jason Long

Front Pharmacol· November 2017

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Local Delivery of OncoVEX Generates Systemic Antitumor Immune Responses Enhanced by Cytotoxic T-Lymphocyte-Associated Protein Blockade.
Achim K Moesta, Keegan Cooke, Julia Piasecki, Petia Mitchell, James B Rottman

Clin Cancer Res· October 2017

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Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses.
Warren N D'Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, James B Rottman

PLoS One· September 2017

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Large-scale gene expression profiling reveals distinct type 2 inflammatory patterns in chronic rhinosinusitis subtypes.
Matthew A Tyler, Chris B Russell, Dirk E Smith, James B Rottman, Caroline J Padro Dietz

J Allergy Clin Immunol· March 2017

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In Vitro and in Vivo Analyses Reveal Profound Effects of Fibroblast Growth Factor 16 as a Metabolic Regulator.
Ingrid C Rulifson, Patrick Collins, Li Miao, Dana Nojima, Ki Jeong Lee, James B Rottman

J Biol Chem· February 2017

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IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma.
Cynthia R Willis, Lori Siegel, Anh Leith, Deanna Mohn, Sabine Escobar, James B Rottman

Am J Respir Cell Mol Biol· December 2015

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Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation.
Joseph R Maxwell, Yu Zhang, William A Brown, Carole L Smith, Fergus R Byrne, James B Rottman

Immunity· October 2015

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Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.
Jacinthe Gingras, Sarah Smith, David J Matson, Danielle Johnson, Kim Nye, James B Rottman

PLoS One· April 2015

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Immunogenicity/hypersensitivity of biologics.
Michael W Leach, James B Rottman, M Benjamin Hock, Deborah Finco, Jennifer L Rojko

Toxicol Pathol· January 2014

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AMG 900, a small-molecule inhibitor of aurora kinases, potentiates the activity of microtubule-targeting agents in human metastatic breast cancer models.
Tammy L Bush, Marc Payton, Scott Heller, Grace Chung, Kelly Hanestad, James B Rottman

Mol Cancer Ther· November 2013

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IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung.
Celine A Beamer, Teri A Girtsman, Benjamin P Seaver, Krissy J Finsaas, Christopher T Migliaccio, James B Rottman

Nanotoxicology· September 2013

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IL-22 regulates iron availability in vivo through the induction of hepcidin.
Carole L Smith, Tara L Arvedson, Keegan S Cooke, Leslie J Dickmann, Carla Forte, James B Rottman

J Immunol· August 2013

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Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells.
Ryan M Swanson, Marc A Gavin, Sabine S Escobar, James B Rottman, Brian P Lipsky

J Immunol· March 2013

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Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity.
Hye Young Kim, Ya-Jen Chang, Srividya Subramanian, Hyun-Hee Lee, Lee A Albacker, James B Rottman

J Allergy Clin Immunol· January 2012

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