Publications by authors named "James Staley"

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Genetic data do not provide evidence that lower sclerostin is associated with increased risk of atherosclerosis: comment on the article by Zheng et al.
James R Staley, Olga Giannakopoulou, Gill Holdsworth, Martin Armstrong

Arthritis Rheumatol· September 2025

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Distilling Direct Effects via Conditional Differential Gene Expression Analysis.
Jiaqi Gu, Andrew Skelton, James Staley, Pierce Popson, Lei Peng

bioRxiv· September 2025

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The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study.
Maria-Carolina Borges, Phillip Haycock, Jie Zheng, Gibran Hemani, Laurence J Howe, James R Staley

Hum Mol Genet· November 2022

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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.
Liam Gaziano, Luanluan Sun, Matthew Arnold, Steven Bell, Kelly Cho, James R Staley

Circulation· November 2022

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The EWAS Catalog: a database of epigenome-wide association studies.
Thomas Battram, Paul Yousefi, Gemma Crawford, Claire Prince, Mahsa Sheikhali Babaei, James R Staley

Wellcome Open Res· May 2022

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A robust mean and variance test with application to high-dimensional phenotypes.
James R Staley, Frank Windmeijer, Matthew Suderman, Matthew S Lyon, George Davey Smith

Eur J Epidemiol· April 2022

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Coding and regulatory variants are associated with serum protein levels and disease.
Valur Emilsson, Valborg Gudmundsdottir, Alexander Gudjonsson, Thorarinn Jonmundsson, Brynjolfur G Jonsson, James R Staley

Nat Commun· January 2022

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DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample.
Radhika Kandaswamy, Eilis Hannon, Louise Arseneault, Georgina Mansell, Karen Sugden, James R Staley

Epigenetics· November 2021

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Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans.
Gill Holdsworth, James R Staley, Peter Hall, Ian van Koeverden, Ciara Vangjeli

J Bone Miner Res· July 2021

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The Effect of Attention Deficit/Hyperactivity Disorder on Physical Health Outcomes: A 2-Sample Mendelian Randomization Study.
Beate Leppert, Lucy Riglin, Robyn E Wootton, Christina Dardani, Ajay Thapar, James R Staley

Am J Epidemiol· June 2021

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Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Praveen Surendran, Elena V Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James R Staley

Nat Genet· May 2021

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A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits.
Christopher N Foley, James R Staley, Philip G Breen, Benjamin B Sun, Paul D W Kirk

Nat Commun· February 2021

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Praveen Surendran, Elena V Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James R Staley

Nat Genet· December 2020

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MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data.
Jim R Broadbent, Christopher N Foley, Andrew J Grant, Amy M Mason, James R Staley

Wellcome Open Res· December 2020

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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Jie Zheng, Valeriia Haberland, Denis Baird, Venexia Walker, Philip C Haycock, James R Staley

Nat Genet· October 2020

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A robust and efficient method for Mendelian randomization with hundreds of genetic variants.
Stephen Burgess, Christopher N Foley, Elias Allara, James R Staley, Joanna M M Howson

Nat Commun· January 2020

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PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations.
Mihir A Kamat, James A Blackshaw, Robin Young, Praveen Surendran, Stephen Burgess, James R Staley

Bioinformatics· November 2019

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Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses.
Yi-Qian Sun, Stephen Burgess, James R Staley, Angela M Wood, Steven Bell

BMJ· March 2019

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Archaea-First and the Co-Evolutionary Diversification of Domains of Life.
James T Staley, Gustavo Caetano-Anollés

Bioessays· August 2018

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Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.
Stephen Burgess, Brian A Ference, James R Staley, Daniel F Freitag, Amy M Mason

JAMA Cardiol· July 2018

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Genomic atlas of the human plasma proteome.
Benjamin B Sun, Joseph C Maranville, James E Peters, David Stacey, James R Staley

Nature· June 2018

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Longitudinal analysis strategies for modelling epigenetic trajectories.
James R Staley, Matthew Suderman, Andrew J Simpkin, Tom R Gaunt, Jon Heron

Int J Epidemiol· April 2018

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A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design.
James R Staley, Edmund Jones, Stephen Kaptoge, Adam S Butterworth, Michael J Sweeting

Eur J Hum Genet· June 2017

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Domain Cell Theory supports the independent evolution of the Eukarya, Bacteria and Archaea and the Nuclear Compartment Commonality hypothesis.
James T Staley

Open Biol· June 2017

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Semiparametric methods for estimation of a nonlinear exposure-outcome relationship using instrumental variables with application to Mendelian randomization.
James R Staley, Stephen Burgess

Genet Epidemiol· May 2017

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