Publications by authors named "James Tamura"

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Preclinical development of MGC028, an ADAM9-targeted, glycan-linked, exatecan-based antibody-drug conjugate for the treatment of solid cancers.
Juniper A Scribner, Jennifer G Brown, Thomas Son, Linda Jin, Carroll McKenzie, James Tamura

Mol Cancer Ther· October 2025

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A Strategy for Simultaneous Engineering of Interspecies Cross-Reactivity, Thermostability, and Expression of a Bispecific 5T4 x CD3 DART Molecule for Treatment of Solid Tumors.
Renhua R Huang, Michael Spliedt, Tom Kaufman, Sergey Gorlatov, Bhaswati Barat, James Tamura

Antibodies (Basel)· January 2025

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Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors.
Juniper A Scribner, Stuart W Hicks, Kerstin W Sinkevicius, Nicholas C Yoder, Gundo Diedrich, James Tamura

Mol Cancer Ther· July 2022

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Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer.
Juniper A Scribner, Jennifer G Brown, Thomas Son, Michael Chiechi, Pam Li, James Tamura

Mol Cancer Ther· November 2020

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Multispecific, Multivalent Antibody-Based Molecules Engineered on the DART® and TRIDENT Platforms.
Ling Huang, Kalpana Shah, Bhaswati Barat, Chia-Ying K Lam, Sergey Gorlatov, James Tamura

Curr Protoc Immunol· June 2020

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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
Aaron P Yamniuk, Anish Suri, Stanley R Krystek, James Tamura, Vidhyashankar Ramamurthy

J Mol Biol· July 2016

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Comparison of Ensemble and Single Molecule Methods for Particle Characterization and Binding Analysis of a PEGylated Single-Domain Antibody.
Lumelle A Schneeweis, Linda Obenauer-Kutner, Parminder Kaur, Aaron P Yamniuk, James Tamura

J Pharm Sci· December 2015

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Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening.
Daniel L Cheney, Jeffrey M Bozarth, William J Metzler, Paul E Morin, Luciano Mueller, James K Tamura

J Med Chem· March 2015

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Engineering of a novel anti-CD40L domain antibody for treatment of autoimmune diseases.
Jenny H Xie, Aaron P Yamniuk, Virna Borowski, Robert Kuhn, Vojkan Susulic, James Tamura

J Immunol· May 2014

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A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety.
Suzanne J Suchard, Patricia M Davis, Selena Kansal, Dawn K Stetsko, Ruth Brosius, James Tamura

J Immunol· November 2013

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Dual universal peptide approach to bioanalysis of human monoclonal antibody protein drug candidates in animal studies.
Michael T Furlong, Song Zhao, William Mylott, Rand Jenkins, Mian Gao, James Tamura

Bioanalysis· June 2013

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A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies.
Michael T Furlong, Zheng Ouyang, Steven Wu, James Tamura, Timothy Olah

Biomed Chromatogr· August 2012

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Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma.
Zheng Ouyang, Michael T Furlong, Steven Wu, Bogdan Sleczka, James Tamura

Bioanalysis· January 2012

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Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.
Wei Meng, Robert P Brigance, Hannguang J Chao, Aberra Fura, Thomas Harrity, James K Tamura

J Med Chem· August 2010

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Characterization of S-thiolation on secreted proteins from E. coli by mass spectrometry.
Peiran Liu, Malloree A Tarnowski, Brian W O'Mara, Wei Wu, Haiying Zhang, James K Tamura

Rapid Commun Mass Spectrom· October 2009

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Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.
Gregory A Locke, Dong Cheng, Mark R Witmer, James K Tamura, Tasir Haque

Arch Biochem Biophys· July 2008

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Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.
William J Metzler, Joseph Yanchunas, Carolyn Weigelt, Kevin Kish, Herbert E Klei, James K Tamura

Protein Sci· February 2008

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Is exogenous tissue plasminogen activator necessary for antithrombotic efficacy of an inhibitor of thrombin activatable fibrinolysis inhibitor (TAFI) in rats?
Eileen Bird, James Tamura, Jeffrey S Bostwick, Thomas E Steinbacher, Anne Stewart

Thromb Res· October 2007

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Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.
Dong Cheng, Ching-Hsuen Chu, Luping Chen, John N Feder, Gabe A Mintier, James K Tamura

Protein Expr Purif· January 2007

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