Publications by authors named "Jamie Spangler"

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Dynamics and variegation in the Treg response to Interleukin-2.
Kumba Seddu, Kaitavjeet Chowdhary, Molly Henderson, Jakub Tomala, Odhran Casey, Jamie B Spangler

Proc Natl Acad Sci U S A· November 2025

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A CD25-chemokine receptor complex initiates non-canonical IL-2 signaling.
Hosup Lee, Sarah Hyun Ji Kim, Javid Aceil, Amelia Meecham, Alexandre Gingras, Jamie B Spangler

J Biol Chem· November 2025

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Adapting antibody-invertase fusion protein immunoassays to multiwell plates for infectious disease antibody quantification.
Elysse Ornelas-Gatdula, Xinran An, Jamie B Spangler, Netzahualcóyotl Arroyo-Currás

Sens Diagn· October 2025

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NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas.
Priyanka Sehgal, Ammar S Naqvi, Makenna Higgins, Jiageng Liu, Kyra Harvey, Jamie B Spangler

bioRxiv· August 2025

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NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas.
Priyanka Sehgal, Ammar S Naqvi, Makenna Higgins, Jiageng Liu, Kyra Harvey, Jamie B Spangler

Cell Rep· August 2025

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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion.
Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Milada Sirova, Katerina Kubesova, Jamie B Spangler

J Immunother Cancer· August 2025

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Bispecific receptor decoy proteins block ocular neovascularization via simultaneous blockade of vascular endothelial growth factor A and C.
Paul R Sargunas, Emily Ariail, Raquel Lima E Silva, Akash Patil, Mingliang Zhang, Jamie B Spangler

Mol Ther· July 2025

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Specific Stimulation and Multiplex Secretion Analysis of T Cells Using a Suspendable Hydrogel Platform Enables Immunophenotyping at the Single-Cell Scale.
Monika Kizerwetter, Doyeon Koo, Citradewi Soemardy, Théo Nass, Joseph Choy, Jamie B Spangler

ACS Nano· July 2025

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Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism.
Hongrui Liu, Yuxuan Cai, Leilei Shi, Meenakshi Pillai, Nilimesh Das, Jamie B Spangler

bioRxiv· July 2025

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Screening of a pooled library of chimeric antigen receptor T cells based on secretory function.
Citradewi Soemardy, Anna Mei, Rocio Castellanos-Rueda, Nikol Garcia Espinoza, Monika Kizerwetter, Jamie B Spangler

bioRxiv· July 2025

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An engineered Treg selective immunocytokine induces sustained immune modulation in a preclinical model of hemophilia A.
Jyoti Rana, Derek VanDyke, Maite Muñoz-Melero, Charina S Fabilane, Senthilkumar Thirumurugan, Jamie B Spangler

J Thromb Haemost· June 2025

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design of miniprotein agonists and antagonists targeting G protein-coupled receptors.
Edin Muratspahić, David Feldman, David E Kim, Xiangli Qu, Ana-Maria Bratovianu, Jamie B Spangler

bioRxiv· June 2025

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Designed endocytosis-inducing proteins degrade targets and amplify signals.
Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Jamie B Spangler

Nature· February 2025

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Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality.
Ruyan Rahnama, Monika Kizerwetter, Huilin Yang, Ilias Christodoulou, Christian Guaraca, Jamie B Spangler

J Immunother Cancer· February 2025

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A CD25-CCR7 complex initiates non-canonical IL-2 signaling.
Sarah Hyun Ji Kim, Hosup Lee, Alexandre Gingras, Klaus Ley, Jamie B Spangler

bioRxiv· February 2025

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Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network.
Claire H Woodward, Shahlo O Solieva, Daniel Hwang, Viviane S De Paula, Charina S Fabilane, Jamie B Spangler

J Mol Biol· January 2025

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Engineering growth factor ligands and receptors for therapeutic innovation.
Xinran An, Justin Paoloni, Yuseong Oh, Jamie B Spangler

Trends Cancer· December 2024

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Production of site-specific antibody conjugates using metabolic glycoengineering and novel Fc glycovariants.
Zachary J Bernstein, Taylor R Gierke, Kris Dammen-Brower, Stephany Y Tzeng, Stanley Zhu, Jamie B Spangler

J Biol Chem· December 2024

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Emerging approaches for T cell-stimulating platform development.
Emily Ariail, Nikol Garcia Espinoza, A Carson Stephenson, Jamie B Spangler

Cell Syst· December 2024

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Regulating IL-2 immune signaling function via a core allosteric structural network.
Claire H Woodward, Shahlo O Solieva, Daniel Hwang, Viviane S De Paula, Charina S Fabilane, Jamie B Spangler

bioRxiv· October 2024

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Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
Elissa K Leonard, Jakub Tomala, Joseph R Gould, Michael I Leff, Jian-Xin Lin, Jamie B Spangler

JCI Insight· September 2024

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Preclinical proof of principle for orally delivered Th17 antagonist miniproteins.
Stephanie Berger, Franziska Seeger, Ta-Yi Yu, Merve Aydin, Huilin Yang, Jamie B Spangler

Cell· August 2024

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Mechanistic computational modeling of monospecific and bispecific antibodies targeting interleukin-6/8 receptors.
Christina M P Ray, Huilin Yang, Jamie B Spangler, Feilim Mac Gabhann

PLoS Comput Biol· June 2024

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Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1.
Seth D Ludwig, Bunyarit Meksiriporn, Jiacheng Tan, Rakeeb Kureshi, Akhilesh Mishra, Jamie B Spangler

Cell Chem Biol· May 2024

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Cytokine/Antibody Fusion Protein Design and Evaluation.
Charina S Fabilane, A Carson Stephenson, Elissa K Leonard, Derek VanDyke, Jamie B Spangler

Curr Protoc· May 2024

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