Publications by authors named "Jan Christian"

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Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice.
Hyung-Seok Kim, Mary L Sanchez, Joshua Silva, Heidi L Schubert, Rebecca Dennis, Jan L Christian

Elife· May 2025

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Mutations that prevent phosphorylation of the BMP4 prodomain impair proteolytic maturation of homodimers leading to lethality in mice.
Hyung-Seok Kim, Mary L Sanchez, Joshua Silva, Heidi L Schubert, Rebecca Dennis, Jan L Christian

bioRxiv· April 2025

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MuSK Regulates Neuromuscular Junction Nav1.4 Localization and Excitability.
Lauren A Fish, Madison D Ewing, Kelly A Rich, Chengjie Xi, Isabella Chen, Jan L Christian

J Neurosci· April 2025

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The prodomain of bone morphogenetic protein 2 promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers.
Pooja Chauhan, Yongqiang Xue, Hyung-Seok Kim, Allison L Fisher, Jodie L Babitt, Jan L Christian

J Biol Chem· October 2024

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The BMP2 prodomain promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers in vivo.
Pooja Chauhan, Yongqiang Xue, Allison L Fisher, Hyung-Seok Kim, Jodie L Babitt, Jan L Christian

bioRxiv· June 2024

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BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice.
Xia Xiao, Yang Xu, Gillian A Moschetta, Yang Yu, Allison L Fisher, Jan Christian

Blood· October 2023

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Lack of evidence that fibrillin1 regulates bone morphogenetic protein 4 activity in kidney or lung.
Autumn McKnite, Hyung-Seok Kim, Joshua Silva, Jan L Christian

Dev Dyn· June 2023

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Transforming growth factor-β family biology: From basic mechanisms to roles in development and disease.
Jan L Christian, Caroline S Hill

Dev Dyn· January 2022

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Tril dampens Nodal signaling through Pellino2- and Traf6-mediated activation of Nedd4l.
Hyung-Seok Kim, Yangsook Song Green, Yuanyuan Xie, Jan L Christian

Proc Natl Acad Sci U S A· September 2021

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Analysis of Transforming Growth Factor ß Family Cleavage Products Secreted Into the Blastocoele of Xenopus laevis Embryos.
Hyung-Seok Kim, Jan L Christian

J Vis Exp· July 2021

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A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
Jan Christian

Proc Natl Acad Sci U S A· May 2021

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BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.
Hyung-Seok Kim, Judith Neugebauer, Autumn McKnite, Anup Tilak, Jan L Christian

Elife· September 2019

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Proteolytic Activation of Bmps: Analysis of Cleavage in Xenopus Oocytes and Embryos.
Hyung-Seok Kim, Autumn McKnite, Jan L Christian

Methods Mol Biol· June 2019

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Fibronectin type III and intracellular domains of Toll-like receptor 4 interactor with leucine-rich repeats (Tril) are required for developmental signaling.
Hyung-Seok Kim, Autumn McKnite, Yuanyuan Xie, Jan L Christian

Mol Biol Cell· March 2018

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The TGFβ superfamily in Lisbon: navigating through development and disease.
Jan L Christian, Carl-Henrik Heldin

Development· December 2017

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Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain.
Wei-Chao Huang, Elliott Ferris, Tong Cheng, Cornelia Stacher Hörndli, Kelly Gleason, Jan L Christian

Neuron· March 2017

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Providing a navigable route for acute medicine nurses to advance their practice: a framework of ascending levels of practice.
Liz Lees-Deutsch, Jan Christian, Ian Setchfield

Acute Med· February 2017

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Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.
Yangsook Song Green, Sunjong Kwon, Mizuho S Mimoto, Yuanyuan Xie, Jan L Christian

Development· November 2016

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PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection.
Marina Tiemi Shio, Jan Gregor Christian, Jee Yong Jung, Kwang-Poo Chang, Martin Olivier

PLoS Negl Trop Dis· May 2016

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Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development.
Yangsook Song Green, Sunjong Kwon, Jan L Christian

Gene Expr Patterns· January 2016

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GATA2 regulates Wnt signaling to promote primitive red blood cell fate.
Mizuho S Mimoto, Sunjong Kwon, Yangsook Song Green, Devorah Goldman, Jan L Christian

Dev Biol· November 2015

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The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo.
Judith M Neugebauer, Sunjong Kwon, Hyung-Seok Kim, Nathan Donley, Anup Tilak, Jan L Christian

Proc Natl Acad Sci U S A· May 2015

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Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity.
Amandine Isnard, Jan G Christian, Mohamed Kodiha, Ursula Stochaj, W Robert McMaster

PLoS Pathog· March 2015

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MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib.
Matthias Wirth, Natasa Stojanovic, Jan Christian, Mariel C Paul, Roland H Stauber

Nucleic Acids Res· January 2015

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Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice.
Anup Tilak, Sylvia M Nelsen, Hyung-Seok Kim, Nathan Donley, Autumn McKnite, Jan L Christian

Development· August 2014

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