Publications by authors named "Jan Claesen"

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The diet-derived gut microbial metabolite 3-phenylpropionic acid reverses insulin resistance and obesity-associated metabolic dysfunction.
Sara Alqudah, Beckey DeLucia, Lucas J Osborn, Rachel L Markley, Viharika Bobba, Jan Claesen

Mol Metab· December 2025

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The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in Apc mice.
Layan Hamidi Nia, Sara Alqudah, Rachel L Markley, Beckey DeLucia, Viharika Bobba, Jan Claesen

Microbiol Spectr· November 2025

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Gut microbial conversion of dietary elderberry extract to hydrocinnamic acid improves obesity-associated metabolic disorders.
Sara Alqudah, Beckey DeLucia, Lucas J Osborn, Rachel L Markley, Viharika Bobba, Jan Claesen

bioRxiv· May 2025

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The antimicrobial metabolite nisin Z reduces intestinal tumorigenesis and modulates the cecal microbiome in Apc mice.
Layan Hamidi Nia, Sara Alqudah, Rachel L Markley, Beckey DeLucia, Viharika Bobba, Jan Claesen

bioRxiv· May 2025

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In vivo virulence of in native versus prosthetic left-sided valve endocarditis.
Haytham Elgharably, Jan Claesen, Naseer Sangwan, Muhammad Etiwy, Penny Houghtaling

JTCVS Open· April 2025

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Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds.
Sara Alqudah, Jan Claesen

Gut Microbes· November 2024

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Predicting cardiovascular disease risk from gut microbial genes.
Jan Claesen, J Mark Brown

mBio· December 2023

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Engineered Cancer Targeting Microbes and Encapsulation Devices for Human Gut Microbiome Applications.
Layan Hamidi Nia, Jan Claesen

Biochemistry· December 2022

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Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer.
Laura M Chambers, Emily L Esakov Rhoades, Rashmi Bharti, Chad Braley, Surabhi Tewari, Jan Claesen

Cancer Res· December 2022

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A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis.
Lucas J Osborn, Karlee Schultz, William Massey, Beckey DeLucia, Ibrahim Choucair, Jan Claesen

Proc Natl Acad Sci U S A· November 2022

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A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation.
Mustafa Özçam, Jee-Hwan Oh, Restituto Tocmo, Deepa Acharya, Shenwei Zhang, Jan Claesen

Cell Host Microbe· June 2022

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A 3D-printable device allowing fast and reproducible longitudinal preparation of mouse intestines.
Beckey DeLucia, Sergey Samorezov, Megan T Zangara, Rachel L Markley, Lucas J Osborn, Jan Claesen

Animal Model Exp Med· April 2022

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Microbial Flavonoid Metabolism: A Cardiometabolic Disease Perspective.
Lucas J Osborn, Jan Claesen, J Mark Brown

Annu Rev Nutr· October 2021

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A Single Human-Relevant Fast Food Meal Rapidly Reorganizes Metabolomic and Transcriptomic Signatures in a Gut Microbiota-Dependent Manner.
Lucas J Osborn, Danny Orabi, Maryam Goudzari, Naseer Sangwan, Rakhee Banerjee, Jan Claesen

Immunometabolism· September 2021

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Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation.
Isabel Johnston, Lucas J Osborn, Rachel L Markley, Elizabeth A McManus, Anagha Kadam, Jan Claesen

NPJ Biofilms Microbiomes· July 2021

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A surgical method for continuous intraportal infusion of gut microbial metabolites in mice.
Danny Orabi, Lucas J Osborn, Kevin Fung, William Massey, Anthony J Horak, Jan Claesen

JCI Insight· May 2021

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A antibiotic modulates human skin microbiota composition in hair follicles.
Jan Claesen, Jennifer B Spagnolo, Stephany Flores Ramos, Kenji L Kurita, Allyson L Byrd

Sci Transl Med· November 2020

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Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut.
Andrew Bell, Jason Brunt, Emmanuelle Crost, Laura Vaux, Ridvan Nepravishta, Jan Claesen

Nat Microbiol· December 2019

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Gut Symbionts Lactobacillus reuteri R2lc and 2010 Encode a Polyketide Synthase Cluster That Activates the Mammalian Aryl Hydrocarbon Receptor.
Mustafa Özçam, Restituto Tocmo, Jee-Hwan Oh, Amin Afrazi, Joshua D Mezrich, Jan Claesen

Appl Environ Microbiol· May 2019

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Topical Antiseptics and the Skin Microbiota.
Jan Claesen

J Invest Dermatol· October 2018

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Contextual control of skin immunity and inflammation by .
Vanessa K Ridaura, Nicolas Bouladoux, Jan Claesen, Y Erin Chen, Allyson L Byrd

J Exp Med· March 2018

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Synthetic biology to access and expand nature's chemical diversity.
Michael J Smanski, Hui Zhou, Jan Claesen, Ben Shen, Michael A Fischbach

Nat Rev Microbiol· March 2016

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Minimum Information about a Biosynthetic Gene cluster.
Marnix H Medema, Renzo Kottmann, Pelin Yilmaz, Matthew Cummings, John B Biggins, Jan Claesen

Nat Chem Biol· September 2015

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A Streptomyces coelicolor host for the heterologous expression of Type III polyketide synthase genes.
Anyarat Thanapipatsiri, Jan Claesen, Juan-Pablo Gomez-Escribano, Mervyn Bibb, Arinthip Thamchaipenet

Microb Cell Fact· September 2015

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Synthetic microbes as drug delivery systems.
Jan Claesen, Michael A Fischbach

ACS Synth Biol· April 2015

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