Publications by authors named "Jan Mach"

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Modular Design of Mitochondrion-Targeted Iron Chelators Allows Highly Selective Antiparasitic Activity against Trypanosomes and Apicomplexan Parasites.
Ronald Malych, Yann Bordat, Kristýna Klanicová, Dominik Arbon, Farnaz Zahedifard, Jan Mach, Marta Machado

ACS Infect Dis· December 2025

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Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri.
Ronald Malych, Filipe Folgosa, Jana Pilátová, Libor Mikeš, Vít Dohnálek, Jan Mach

PLoS Pathog· March 2025

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Molecular Mechanisms of Response to Different Sources of Oxidative Stress.
Kateřina Ženíšková, Pavel Stopka, Tania Martín-Pérez, Guillaume Chevreux, Maria Grechnikova, Jan Mach

J Proteome Res· February 2025

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Chelation of Mitochondrial Iron as an Antiparasitic Strategy.
Dominik Arbon, Jan Mach, Aneta Čadková, Anna Sipkova, Jan Stursa, Marta Machado

ACS Infect Dis· February 2024

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The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis.
Kateřina Ženíšková, Jan Mach, Dominik Arbon, Jan Štursa, Lukáš Werner

Antimicrob Agents Chemother· February 2023

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In vivo localization of iron starvation induced proteins under variable iron supplementation regimes in .
Elena Kazamia, Jan Mach, Jeffrey B McQuaid, Xia Gao, Tyler H Coale

Plant Direct· December 2022

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Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens.
Dominik Arbon, Kateřina Ženíšková, Karolína Šubrtová, Jan Mach, Jan Štursa, Marta Machado

Antimicrob Agents Chemother· August 2022

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Elucidation of iron homeostasis in Acanthamoeba castellanii.
Maria Grechnikova, Dominik Arbon, Kateřina Ženíšková, Ronald Malych, Jan Mach

Int J Parasitol· July 2022

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Flow cytometry-based study of model marine microalgal consortia revealed an ecological advantage of siderophore utilization by the dinoflagellate .
Ronald Malych, Pavel Stopka, Jan Mach, Eva Kotabová, Ondřej Prášil

Comput Struct Biotechnol J· December 2021

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The Mastigamoeba balamuthi Genome and the Nature of the Free-Living Ancestor of Entamoeba.
Vojtěch Žárský, Vladimír Klimeš, Jan Pačes, Čestmír Vlček, Miluše Hradilová, Jan Mach

Mol Biol Evol· May 2021

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Complex Response of the Chlorarachniophyte Bigelowiella natans to Iron Availability.
Eva Kotabova, Ronald Malych, Juan José Pierella Karlusich, Elena Kazamia, Meri Eichner, Jan Mach

mSystems· February 2021

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Copper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system.
Maria Grechnikova, Kateřina Ženíšková, Ronald Malych, Jan Mach, Robert Sutak

Int J Parasitol Drugs Drug Resist· December 2020

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Iron in parasitic protists - from uptake to storage and where we can interfere.
Jan Mach, Robert Sutak

Metallomics· September 2020

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Adaptive iron utilization compensates for the lack of an inducible uptake system in Naegleria fowleri and represents a potential target for therapeutic intervention.
Dominik Arbon, Kateřina Ženíšková, Jan Mach, Maria Grechnikova, Ronald Malych

PLoS Negl Trop Dis· June 2020

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Copper and iron metabolism in Ostreococcus tauri - the role of phytotransferrin, plastocyanin and a chloroplast copper-transporting ATPase.
Ivo Florin Scheiber, Jana Pilátová, Ronald Malych, Eva Kotabova, Matyáš Krijt, Jan Mach

Metallomics· October 2019

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Trypanosomal mitochondrial intermediate peptidase does not behave as a classical mitochondrial processing peptidase.
Priscila Peña-Diaz, Jan Mach, Eva Kriegová, Pavel Poliak, Jan Tachezy

PLoS One· August 2018

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Iron economy in Naegleria gruberi reflects its metabolic flexibility.
Jan Mach, Jarmila Bíla, Kateřina Ženíšková, Dominik Arbon, Ronald Malych

Int J Parasitol· August 2018

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Endocytosis-mediated siderophore uptake as a strategy for Fe acquisition in diatoms.
Elena Kazamia, Robert Sutak, Javier Paz-Yepes, Richard G Dorrell, Fabio Rocha Jimenez Vieira, Jan Mach

Sci Adv· May 2018

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Mitochondrial pyruvate carrier in Trypanosoma brucei.
Jitka Štáfková, Jan Mach, Marc Biran, Zdeněk Verner, Frédéric Bringaud

Mol Microbiol· May 2016

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Lateral gene transfer and gene duplication played a key role in the evolution of Mastigamoeba balamuthi hydrogenosomes.
Eva Nývltová, Courtney W Stairs, Ivan Hrdý, Jakub Rídl, Jan Mach

Mol Biol Evol· April 2015

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An Advanced System of the Mitochondrial Processing Peptidase and Core Protein Family in Trypanosoma brucei and Multiple Origins of the Core I Subunit in Eukaryotes.
Jan Mach, Pavel Poliak, Anna Matusková, Vojtĕch Zárský, Jirí Janata

Genome Biol Evol· December 2013

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Efficient iron uptake via a reductive mechanism in procyclic Trypanosoma brucei.
Jan Mach, Jan Tachezy, Robert Sutak

J Parasitol· April 2013

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Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologues in trypanosomes.
Shaojun Long, Milan Jirků, Jan Mach, Michael L Ginger, Robert Sutak

Mol Microbiol· July 2008

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