Publications by authors named "Jan N Commandeur"

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Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.
Yongjie Zhang, Nico P E Vermeulen, Jan N M Commandeur

Br J Clin Pharmacol· March 2017

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Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.
Stefan J Dekker, Yongjie Zhang, J Chris Vos, Nico P E Vermeulen, Jan N M Commandeur

Chem Res Toxicol· December 2016

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Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.
Michiel W den Braver, Yongjie Zhang, Harini Venkataraman, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· July 2016

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Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation.
Luigi Capoferri, Marlies C A Verkade-Vreeker, Danny Buitenhuis, Jan N M Commandeur, Manuel Pastor

PLoS One· June 2016

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Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer.
Shalenie P den Braver-Sewradj, Michiel W den Braver, Nico P E Vermeulen, Jan N M Commandeur, Lysiane Richert

Toxicol In Vitro· June 2016

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Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.
Michiel W den Braver, Shalenie P den Braver-Sewradj, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· June 2016

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Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations.
Luigi Capoferri, Rasmus Leth, Ernst ter Haar, Arun K Mohanty, Peter D J Grootenhuis, Jan N M Commandeur

Proteins· March 2016

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Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.
Jelle Reinen, Geert Postma, Cornelis Tump, Tom Bloemberg, Jasper Engel, Jan N M Commandeur

Anal Bioanal Chem· February 2016

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Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants.
Jelle Reinen, Daniel van Hemert, Nico P E Vermeulen, Jan N M Commandeur

J Biomol Screen· December 2015

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Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme.
Harini Venkataraman, Evelien M Te Poele, Kamila Z Rosłoniec, Nico Vermeulen, Jan N M Commandeur

Appl Microbiol Biotechnol· June 2015

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Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP).
Jelle Reinen, Leyla Nematollahi, Alex Fidder, Nico P E Vermeulen, Daan Noort, Jan N M Commandeur

Chem Res Toxicol· April 2015

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Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants.
Galvin Vredenburg, Shalenie den Braver-Sewradj, Barbara M A van Vugt-Lussenburg, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· January 2015

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Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites.
Jan Simon Boerma, Naura S Elias, Nico P E Vermeulen, Jan N M Commandeur

J Pharm Biomed Anal· January 2015

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Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.
Harini Venkataraman, Michiel W den Braver, Nico P E Vermeulen, Jan N M Commandeur

Chem Res Toxicol· December 2014

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Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.
Harini Venkataraman, Marlies C A Verkade-Vreeker, Luigi Capoferri, Daan P Geerke, Nico P E Vermeulen, Jan N M Commandeur

Bioorg Med Chem· October 2014

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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.
Sreenivasa C Ramaiahgari, Michiel W den Braver, Bram Herpers, Valeska Terpstra, Jan N M Commandeur

Arch Toxicol· May 2014

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Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Galvin Vredenburg, Naura S Elias, Harini Venkataraman, Delilah F G Hendriks, Nico P E Vermeulen, Jan N M Commandeur

Chem Res Toxicol· April 2014

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Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.
Sanja Dragovic, Harini Venkataraman, Selina Begheijn, Nico P E Vermeulen, Jan N M Commandeur

Toxicol Lett· January 2014

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One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
Jan Simon Boerma, Nico P E Vermeulen, Jan N M Commandeur

Chem Biol Interact· January 2014

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Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
Sanja Dragovic, Jan Simon Boerma, Nico P E Vermeulen, Jan N M Commandeur

Chem Res Toxicol· November 2013

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Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.
Galvin Vredenburg, Kadene P T Vassell, Jan N M Commandeur, Nico P E Vermeulen, J Chris Vos

Toxicol Lett· October 2013

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Characterization of human cytochrome P450s involved in the bioactivation of clozapine.
Sanja Dragovic, Patrina Gunness, Magnus Ingelman-Sundberg, Nico P E Vermeulen, Jan N M Commandeur

Drug Metab Dispos· March 2013

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AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver.
Mackenzie Hadi, Sanja Dragovic, Rachel van Swelm, Bram Herpers, Bob van de Water, Jan N M Commandeur

Arch Toxicol· January 2013

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Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.
Jan Simon Boerma, Sanja Dragovic, Nico P E Vermeulen, Jan N M Commandeur

Chem Res Toxicol· November 2012

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A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.
Harini Venkataraman, Stephanie B A de Beer, Laura A H van Bergen, Nick van Essen, Daan P Geerke, Jan N M Commandeur

Chembiochem· March 2012

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