Publications by authors named "Jan Pinkas"

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Quantitation of total antibody (tAb) from antibody drug conjugate (ADC) PYX-201 in rat and monkey plasma using an enzyme-linked immunosorbent assay (ELISA) and its application in preclinical studies.
Feng Yin, Chris DeCiantis, Jan Pinkas, Biplab Das, Frank Wang

J Pharm Biomed Anal· September 2023

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Development and validation of a hybrid immunoaffinity LC-MS/MS assay for quantitation of total antibody (TAb) from an antibody drug conjugate (ADC) PYX-201 in human plasma.
Feng Yin, Diana Adhikari, Marlking Peay, Diego Cortes, Mohammed Garada, Jan Pinkas

J Chromatogr B Analyt Technol Biomed Life Sci· August 2023

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A sensitive and rapid LC-MS/MS assay for quantitation of free payload Aur0101 from antibody drug conjugate (ADC) PYX-201 in human plasma.
Feng Yin, Diana Adhikari, Yan Li, Devan Turner, M Shane Woolf, Jan Pinkas

J Chromatogr B Analyt Technol Biomed Life Sci· July 2023

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A sensitive LC-MS/MS assay to quantitate free payload Aur0101 from ADC PYX-201 in rat and monkey plasma.
Feng Yin, Farah Ahsan, Jan Pinkas, Biplab Das, Frank Wang

Bioanalysis· July 2023

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Bioanalysis of an antibody drug conjugate (ADC) PYX-201 in human plasma using a hybrid immunoaffinity LC-MS/MS approach.
Feng Yin, Diana Adhikari, Minghao Sun, M Shane Woolf, Eric Ma, Jan Pinkas

J Chromatogr B Analyt Technol Biomed Life Sci· May 2023

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Quantification of antibody-drug conjugate PYX-201 in rat and monkey plasma via ELISA and its application in preclinical studies.
Feng Yin, Chris DeCiantis, Jan Pinkas, Biplab Das, Frank Wang

Bioanalysis· January 2023

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Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody-Drug Conjugates to Increase Efficacy.
Jose F Ponte, Leanne Lanieri, Eshita Khera, Rassol Laleau, Olga Ab, Jan Pinkas

Mol Cancer Ther· January 2021

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An Antibody-Drug Conjugate Targeting MUC1-Associated Carbohydrate CA6 Shows Promising Antitumor Activities.
Céline Nicolazzi, Anne Caron, Alexia Tellier, Marc Trombe, Jan Pinkas

Mol Cancer Ther· August 2020

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Evaluation of Prophylactic Corticosteroid Eye Drop Use in the Management of Corneal Abnormalities Induced by the Antibody-Drug Conjugate Mirvetuximab Soravtansine.
Ursula A Matulonis, Michael J Birrer, David M O'Malley, Kathleen N Moore, Jason Konner, Jan Pinkas

Clin Cancer Res· March 2019

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IMGN779, a Novel CD33-Targeting Antibody-Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML.
Yelena Kovtun, Paul Noordhuis, Kathleen R Whiteman, Krystal Watkins, Gregory E Jones, Jan Pinkas

Mol Cancer Ther· June 2018

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A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.
Yelena Kovtun, Gregory E Jones, Sharlene Adams, Lauren Harvey, Charlene A Audette, Jan Pinkas

Blood Adv· April 2018

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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs).
Michael L Miller, Manami Shizuka, Alan Wilhelm, Paulin Salomon, Emily E Reid, Jan Pinkas

Mol Cancer Ther· March 2018

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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
Xiuxia Sun, Jose F Ponte, Nicholas C Yoder, Rassol Laleau, Jennifer Coccia, Jan Pinkas

Bioconjug Chem· May 2017

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Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies.
Kurt Schönfeld, Chantal Zuber, Jan Pinkas, Thomas Häder, Katrin Bernöster

J Hematol Oncol· January 2017

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Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, Potentiates the Activity of Standard of Care Therapeutics in Ovarian Cancer Models.
Jose F Ponte, Olga Ab, Leanne Lanieri, Jenny Lee, Jennifer Coccia, Jan Pinkas

Neoplasia· December 2016

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A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity.
Michael L Miller, Nathan E Fishkin, Wei Li, Kathleen R Whiteman, Yelena Kovtun, Jan Pinkas

Mol Cancer Ther· August 2016

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Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
Jose F Ponte, Xiuxia Sun, Nicholas C Yoder, Nathan Fishkin, Rassol Laleau, Jan Pinkas

Bioconjug Chem· July 2016

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IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors.
Olga Ab, Kathleen R Whiteman, Laura M Bartle, Xiuxia Sun, Rajeeva Singh, Jan Pinkas

Mol Cancer Ther· July 2015

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A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies.
Jutta Deckert, Peter U Park, Sharon Chicklas, Yong Yi, Min Li, Jan Pinkas

Blood· November 2013

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The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates.
Hans K Erickson, Gail D Lewis Phillips, Douglas D Leipold, Carmela A Provenzano, Elaine Mai, Jan Pinkas

Mol Cancer Ther· May 2012

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RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Eva Gonzalez-Suarez, Allison P Jacob, Jon Jones, Robert Miller, Martine P Roudier-Meyer, Jan Pinkas

Nature· November 2010

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Antibody-maytansinoid conjugates designed to bypass multidrug resistance.
Yelena V Kovtun, Charlene A Audette, Michele F Mayo, Gregory E Jones, Heather Doherty, Jan Pinkas

Cancer Res· March 2010

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Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration.
Stephanie A Yazinski, Peter M K Westcott, Kelly Ong, Jan Pinkas, Rachel M Peters

Proc Natl Acad Sci U S A· December 2009

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Mutation of the murine Bloom's syndrome gene produces global genome destabilization.
Nicholas Chester, Holger Babbe, Jan Pinkas, Charlene Manning, Philip Leder

Mol Cell Biol· September 2006

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Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer.
Jeong-Seok Nam, Adam M Suchar, Mi-Jin Kang, Christina H Stuelten, Binwu Tang, Jan Pinkas

Cancer Res· June 2006

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