Publications by authors named "Jane Sayer"

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Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.
Joon H Park, Jane M Sayer, Annie Aniana, Xiaxia Yu, Irene T Weber

Biochemistry· April 2016

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Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations.
John M Louis, Annie Aniana, Katheryn Lohith, Jane M Sayer, Julien Roche

PLoS One· December 2015

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Mutations Proximal to Sites of Autoproteolysis and the α-Helix That Co-evolve under Drug Pressure Modulate the Autoprocessing and Vitality of HIV-1 Protease.
John M Louis, Lalit Deshmukh, Jane M Sayer, Annie Aniana, G Marius Clore

Biochemistry· September 2015

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Exploring selection and recruitment processes for newly qualified nurses: a sequential-explanatory mixed-method study.
Paul Newton, Val Chandler, Trish Morris-Thomson, Jane Sayer, Linda Burke

J Adv Nurs· January 2015

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Recruiting competent newly qualified nurses in the London region: An exploratory study.
Linda Burke, Jane Sayer, Trish Morris-Thompson, Di Marks-Maran

Nurse Educ Today· October 2014

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The challenge of change in acute mental health services: measuring staff perceptions of barriers to change and their relationship to job status and satisfaction using a new measure (VOCALISE).
Caroline Laker, Felicity Callard, Clare Flach, Paul Williams, Jane Sayer

Implement Sci· February 2014

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Enhanced stability of monomer fold correlates with extreme drug resistance of HIV-1 protease.
John M Louis, József Tözsér, Julien Roche, Krisztina Matúz, Annie Aniana, Jane M Sayer

Biochemistry· October 2013

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Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran.
Johnson Agniswamy, Chen-Hsiang Shen, Yuan-Fang Wang, Arun K Ghosh, Kalapala Venkateswara Rao, Jane M Sayer

J Med Chem· May 2013

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Equality of employment opportunities for nurses at the point of qualification: an exploratory study.
Ruth Harris, Ann Ooms, Robert Grant, Sylvie Marshall-Lucette, Christine Sek Fun Chu, Jane Sayer

Int J Nurs Stud· March 2013

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Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Yijin Tang, Zhi Liu, Shuang Ding, Chin H Lin, Yuqin Cai, Jane M Sayer

Biochemistry· December 2012

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Mechanism of dissociative inhibition of HIV protease and its autoprocessing from a precursor.
Jane M Sayer, Annie Aniana, John M Louis

J Mol Biol· September 2012

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HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Johnson Agniswamy, Chen-Hsiang Shen, Annie Aniana, Jane M Sayer, John M Louis

Biochemistry· April 2012

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Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.
Johnson Agniswamy, Jane M Sayer, Irene T Weber, John M Louis

Biochemistry· February 2012

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The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.
John M Louis, Ying Zhang, Jane M Sayer, Yuan-Fang Wang, Robert W Harrison

Biochemistry· May 2011

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Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors.
John M Louis, Annie Aniana, Irene T Weber, Jane M Sayer

Proc Natl Acad Sci U S A· May 2011

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Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.
Jane M Sayer, Johnson Agniswamy, Irene T Weber, John M Louis

Protein Sci· November 2010

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Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease.
John M Louis, Rieko Ishima, Annie Aniana, Jane M Sayer

Protein Sci· December 2009

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Modulation of human immunodeficiency virus type 1 protease autoprocessing by charge properties of surface residue 69.
Liangqun Huang, Jane M Sayer, Marie Swinford, John M Louis, Chaoping Chen

J Virol· August 2009

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Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
Jane M Sayer, John M Louis

Proteins· May 2009

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3'-Intercalation of a N2-dG 1R-trans-anti-benzo[c]phenanthrene DNA adduct in an iterated (CG)3 repeat.
Yazhen Wang, Nathalie C Schnetz-Boutaud, Heiko Kroth, Haruhiko Yagi, Jane M Sayer

Chem Res Toxicol· July 2008

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Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease.
Jane M Sayer, Fengling Liu, Rieko Ishima, Irene T Weber, John M Louis

J Biol Chem· May 2008

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A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment.
Jacob Bauer, Guangxin Xing, Haruhiko Yagi, Jane M Sayer, Donald M Jerina

Proc Natl Acad Sci U S A· September 2007

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3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides.
Prema C Iyer, Haruhiko Yagi, Jane M Sayer, Donald M Jerina

Chem Res Toxicol· February 2007

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Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
Vinod K Batra, David D Shock, Rajendra Prasad, William A Beard, Esther W Hou, Jane M Sayer

Proc Natl Acad Sci U S A· November 2006

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Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding: role of DNA backbone flexibility and an open catalytic site.
Allison A Johnson, Jane M Sayer, Haruhiko Yagi, Sachindra S Patil, Françoise Debart

J Biol Chem· October 2006

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