Publications by authors named "Janey Wiggs"

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Using Genetics for Glaucoma Screening and Risk Stratification: The LXXXII Edward Jackson Memorial Lecture.
Janey L Wiggs

Am J Ophthalmol· January 2026

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Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal study on aging.
Xiaofan Jiang, Omar A Mahroo, Anthony P Khawaja, Dorota Skowronska-Krawczyk, David A Mackey, Janey L Wiggs

Epigenetics· December 2025

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Dual-Level Pattern Tree for Visual Field Improves Glaucoma Progression and Polygenic Risk Prediction.
Luo Song, Lucy Q Shen, Louis R Pasquale, Michael V Boland, Sarah R Wellik, Janey L Wiggs

Transl Vis Sci Technol· December 2025

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ChatGPT-Assisted Glaucoma Diagnosis: A Health-Equitable Multi-Ancestry Analysis Using Visual Field and Optical Coherence Tomography Data.
Andy S Huang, Anthony Fam, Hetince Zhao, Nicole Paulescu, Anna Fabczak-Kubicka, Janey L Wiggs

Am J Ophthalmol· December 2025

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Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms.
Maryam Marzban, Santiago Diaz-Torres, Jackson Thorp, Jue Sheng Ong, Anthony P Khawaja, Janey L Wiggs

Hum Mol Genet· November 2025

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Deep-learning-derived glaucoma-related endophenotypes enable novel genome-wide genetic and functional discovery.
Liyin Chen, Yan Zhao, Saber Kazeminasab Hashemabad, Tobias Elze, Mohammad Eslami, Janey L Wiggs

medRxiv· November 2025

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Female Reproductive Factors in Relation to Risk of Exfoliation Glaucoma or Glaucoma Suspect.
Jae H Kang, Zhiyu Wu, Megan Yu, Hannah H Hwang, Namuunaa Juramt, Janey L Wiggs

Am J Ophthalmol· October 2025

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Genetic Risk for Open-Angle Glaucoma Subtypes Is Associated with Specific Visual Field Defect Classes.
Sayuri Sekimitsu, Kavin Selvan, Yan Zhao, Saber Kazeminasab Hashemabad, Mohammad Eslami, Janey L Wiggs

Ophthalmology· September 2025

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Glaucoma Genetics: Lessons Learned and the New Frontier.
Janey L Wiggs, Louis R Pasquale

Ophthalmol Glaucoma· September 2025

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Recall by polygenic risk score in two biobanks supports a genomic approach for glaucoma detection.
Janey Wiggs, Louis Pasquale, Hetince Zhao, Nazlee Zebardast, Kanza Aziz

Res Sq· August 2025

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Metabolomic Signatures and Predictive Utility of -Associated Genetic Risk Scores for Exfoliation Syndrome/Glaucoma in US Cohorts.
Namuunaa Juramt, Oana A Zeleznik, Louis R Pasquale, Janey L Wiggs, Jae H Kang

Metabolites· August 2025

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Childhood or adolescent abuse and primary open-angle glaucoma in a longitudinal cohort of women.
Megan Yu, Hannah H Hwang, Andrea L Roberts, Karestan C Koenen, Janey L Wiggs

Eye (Lond)· July 2025

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Polygenic Risk Prediction for Normal-Tension Glaucoma.
Maryam Marzban, Santiago Diaz Torres, Regina Yu, Weixiong He, David A Mackey, Janey Wiggs

Invest Ophthalmol Vis Sci· July 2025

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Prediagnostic Plasma Metabolomic Profiles Using NMR for Exfoliation Glaucoma Among US Health Professionals.
Akiko Hanyuda, Oana A Zeleznik, Yoshihiko Raita, Danielle E Haslam, Qi Sun, Janey L Wiggs

Metabolites· July 2025

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Analysis of early-onset glaucoma genes in primary congenital glaucoma patients residing in North India identifies an additional case with Arg1034Cys.
Bindu I Somarajan, Renu Singh, Arnav Panigrahi, Arundhati Sharma, Shikha Gupta, Janey L Wiggs

Ophthalmic Genet· June 2025

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Axenfeld-Rieger syndrome associated with a megabase-scale inversion separating from a conserved enhancer locus.
Lucas A Mitchell, Joshua Schmidt, Emmanuelle Souzeau, Lachlan S W Knight, Giorgina Maxwell, Janey L Wiggs

medRxiv· June 2025

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Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma.
Keva Li, Nicholas Tolman, Ayellet V Segrè, Kelsey V Stuart, Oana A Zeleznik, Janey L Wiggs

Elife· April 2025

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Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma.
Keva Li, Nicholas Tolman, Ayellet V Segrè, Kelsey V Stuart, Oana A Zeleznik, Janey L Wiggs

bioRxiv· March 2025

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Glaucoma - Genes and Mechanisms.
Wolfgang Baehr, Bo Chen, Janey Wiggs

Vision Res· March 2025

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Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson's disease risk.
Elaine Gy Chew, Zhehao Liu, Zheng Li, Sun Ju Chung, Michelle M Lian, Janey L Wiggs

Nat Aging· February 2025

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Does Age Modify the Relation Between Genetic Predisposition to Glaucoma and Various Glaucoma Traits in the UK Biobank?
Jihye Kim, Jae H Kang, Janey L Wiggs, Hetince Zhao, Keva Li

Invest Ophthalmol Vis Sci· February 2025

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ATXN2 loss of function results in glaucoma-related features supporting a role for Ataxin-2 in primary open-angle glaucoma (POAG) pathogenesis.
Shi Song Rong, Anna Larson, Janey L Wiggs,

Vision Res· January 2025

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Machine Learning on Prediagnostic Metabolite Data Identifies Etiologic Endotypes of Exfoliation Glaucoma in United States Health Professionals.
Akiko Hanyuda, Oana A Zeleznik, Yoshihiko Raita, Kazuno Negishi, Louis R Pasquale, Janey L Wiggs

Ophthalmol Sci· December 2024

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Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis of a Randomized Clinical Trial.
Sayuri Sekimitsu, Nabil Ghazal, Kanza Aziz, Yan Zhao, Rishabh K Singh, Janey L Wiggs

JAMA Ophthalmol· November 2024

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Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.
Santiago Diaz-Torres, Weixiong He, Regina Yu, , Anthony P Khawaja, Janey L Wiggs

Nat Commun· November 2024

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