Publications by authors named "Janis Leitans"

Claim this Profile
D
Di--Substituted Fluorinated Benzenesulfonamides as Potent and Selective Anticancer Inhibitors of Carbonic Anhydrase IX and XII.
Aivaras Vaškevičius, Mantas Žvirblis, Maija Kurtenoka, Janis Leitans, Elena Manakova

J Med Chem· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Affinity and Selectivity of Protein-Ligand Recognition: A Minor Chemical Modification Changes Carbonic Anhydrase Binding Profile.
Audrius Zakšauskas, Vaida Paketurytė-Latvė, Alberta Janku̅naitė, Edita Čapkauskaitė, Yann Becart, Janis Leitans

J Med Chem· August 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Surface Functionalization of ITO for Dual-Mode Hypoxia-Associated Cancer Biomarker Detection.
Edmunds Zutis, Gunita Paidere, Rihards Ruska, Toms Freimanis, Janis Cipa, Janis Leitans

Biosensors (Basel)· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX.
Aivaras Vaškevičius, Denis Baronas, Janis Leitans, Agnė Kvietkauskaitė, Audronė Rukšėnaitė

Elife· December 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
From X-ray crystallographic structure to intrinsic thermodynamics of protein-ligand binding using carbonic anhydrase isozymes as a model system.
Vaida Paketurytė-Latvė, Alexey Smirnov, Elena Manakova, Lina Baranauskiene, Vytautas Petrauskas, Janis Leitans

IUCrJ· July 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX.
Janis Leitans, Andris Kazaks, Janis Bogans, Claudiu T Supuran, Inara Akopjana

ChemMedChem· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX.
Audrius Zakšauskas, Edita Čapkauskaitė, Vaida Paketurytė-Latvė, Alexey Smirnov, Janis Leitans

Int J Mol Sci· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.
Virginija Dudutienė, Asta Zubrienė, Visvaldas Kairys, Alexey Smirnov, Joana Smirnovienė, Janis Leitans

Biophys J· October 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Aryl-4,5-dihydro-1-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII.
Priya Hargunani, Nikhil Tadge, Mariangela Ceruso, Janis Leitans, Andris Kazaks

Int J Mol Sci· April 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.
Audrius Zakšauskas, Edita Čapkauskaitė, Linas Jezepčikas, Vaida Linkuvienė, Vaida Paketurytė, Janis Leitans

Eur J Med Chem· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation.
Victor Kartsev, Athina Geronikaki, Silvia Bua, Alessio Nocentini, Anthi Petrou, Janis Leitans

Molecules· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of novel dipeptide sulfonamide conjugates with effective carbonic anhydrase I, II, IX, and XII inhibitory properties.
Nesrin Buğday, F Zehra Küçükbay, Hasan Küçükbay, Silvia Bua, Gianluca Bartolucci, Janis Leitans

Bioorg Chem· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells.
Justina Kazokaitė, Raymon Niemans, Virginija Dudutienė, Holger M Becker, Jānis Leitāns

Oncotarget· June 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors.
Halise Inci Gul, Cem Yamali, Hiroshi Sakagami, Andrea Angeli, Janis Leitans

Bioorg Chem· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
3
3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors.
Aleksandrs Pustenko, Dmitrijs Stepanovs, Raivis Žalubovskis, Daniela Vullo, Andris Kazaks, Janis Leitans

J Enzyme Inhib Med Chem· December 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
-
-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms.
Giulia Bianco, Rita Meleddu, Simona Distinto, Filippo Cottiglia, Marco Gaspari, Janis Leitans

ACS Med Chem Lett· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.
Jekaterīna Ivanova, Fabrizio Carta, Daniela Vullo, Janis Leitans, Andris Kazaks

Bioorg Med Chem· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
5
5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.
Jekaterīna Ivanova, Agnese Balode, Raivis Žalubovskis, Janis Leitans, Andris Kazaks

Bioorg Med Chem· February 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.
Dace Rasina, Martins Otikovs, Janis Leitans, Rosario Recacha, Oleksandr V Borysov

J Med Chem· January 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.
Rosario Recacha, Janis Leitans, Inara Akopjana, Lilija Aprupe, Peteris Trapencieris

Acta Crystallogr F Struct Biol Commun· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX.
Janis Leitans, Andris Kazaks, Agnese Balode, Jekaterina Ivanova, Raivis Zalubovskis

J Med Chem· November 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
X
X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors.
Jekaterina Ivanova, Janis Leitans, Muhammet Tanc, Andris Kazaks, Raivis Zalubovskis

Chem Commun (Camb)· April 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.
Kristaps Jaudzems, Kaspars Tars, Gundars Maurops, Natalija Ivdra, Martins Otikovs, Janis Leitans

ACS Med Chem Lett· April 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting carnitine biosynthesis: discovery of new inhibitors against γ-butyrobetaine hydroxylase.
Kaspars Tars, Janis Leitans, Andris Kazaks, Diana Zelencova, Edgars Liepinsh

J Med Chem· March 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
5
5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.
Janis Leitans, Agnese Sprudza, Muhammet Tanc, Igor Vozny, Raivis Zalubovskis

Bioorg Med Chem· September 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis