Publications by authors named "Jason A Segreti"

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Suppression of superoxide/hydrogen peroxide production at mitochondrial site I decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.
Mark A Watson, Harmanmeet Brar, Edwin T Gibbs, Hoi-Shan Wong, Pratiksha A Dighe, Jason A Segreti

Free Radic Biol Med· August 2023

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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats.
James J Lynch, Emilie Rossignol, Joerg J Moehrle, Terry R Van Vleet, Kennan C Marsh, Jason A Segreti

J Pharmacol Toxicol Methods· May 2019

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Simultaneous measurement of arterial and left ventricular pressure in conscious freely moving rats by telemetry.
Jason A Segreti, James S Polakowski, Eric A Blomme, Andrew J King

J Pharmacol Toxicol Methods· December 2016

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Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists.
Arthur Gomtsyan, Robert G Schmidt, Erol K Bayburt, Gregory A Gfesser, Eric A Voight, Jason A Segreti

J Med Chem· May 2016

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TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats.
Arthur Gomtsyan, Heath A McDonald, Robert G Schmidt, Jerome F Daanen, Eric A Voight, Jason A Segreti

Temperature (Austin)· May 2016

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Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
Eric A Voight, Arthur R Gomtsyan, Jerome F Daanen, Richard J Perner, Robert G Schmidt, Jason A Segreti

J Med Chem· September 2014

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Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature.
Regina M Reilly, Heath A McDonald, Pamela S Puttfarcken, Shailen K Joshi, LaGeisha Lewis, Jason A Segreti

J Pharmacol Exp Ther· August 2012

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Identification and preliminary characterization of a potent, safe, and orally efficacious inhibitor of acyl-CoA:diacylglycerol acyltransferase 1.
Vince S C Yeh, David W A Beno, Sevan Brodjian, Michael E Brune, Steven C Cullen, Jason A Segreti

J Med Chem· February 2012

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Vitamin d receptor activation mitigates the impact of uremia on endothelial function in the 5/6 nephrectomized rats.
J Ruth Wu-Wong, William Noonan, Masaki Nakane, Kristin A Brooks, Jason A Segreti

Int J Endocrinol· July 2011

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Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Jun Chen, Shailen K Joshi, Stanley DiDomenico, Richard J Perner, Joe P Mikusa, Jason A Segreti

Pain· May 2011

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In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia.
Andrew J King, Jason A Segreti, Kelly J Larson, Andrew J Souers, Philip R Kym

Eur J Pharmacol· July 2010

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Tumour-selective antivascular effects of the novel anti-mitotic compound A-318315: An in vivo rat regional haemodynamic study.
Jason A Segreti, Kristin A Brooks, Kennan C Marsh, Joy L Bauch, Yan Lan

Clin Exp Pharmacol Physiol· May 2010

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Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster.
Andrew J King, Jason A Segreti, Kelly J Larson, Andrew J Souers, Philip R Kym

J Pharmacol Exp Ther· August 2009

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Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition.
Pamela H Franklin, Patricia N Banfor, Paul Tapang, Jason A Segreti, Deborah L Widomski

J Pharmacol Exp Ther· June 2009

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Antagonism of TRPV1 receptors indirectly modulates activity of thermoregulatory neurons in the medial preoptic area of rats.
Steve McGaraughty, Jason A Segreti, Ryan M Fryer, Brian S Brown, Connie R Faltynek

Brain Res· May 2009

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Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Prisca Honore, Prasant Chandran, Gricelda Hernandez, Donna M Gauvin, Joseph P Mikusa, Jason A Segreti

Pain· March 2009

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ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats.
Patricia N Banfor, Pamela A Franklin, Jason A Segreti, Deborah L Widomski, Steven K Davidsen

J Cardiovasc Pharmacol· February 2009

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Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure.
Jason A Segreti, Kennan C Marsh, James S Polakowski, Ryan M Fryer

J Pharmacol Exp Ther· April 2008

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Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet.
Ryan M Fryer, Jason A Segreti, Deborah L Widomski, Pamela H Franklin, Patricia N Banfor

J Pharmacol Exp Ther· October 2007

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Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
Irene Drizin, Arthur Gomtsyan, Erol K Bayburt, Robert G Schmidt, Guo Zhu Zheng, Jason A Segreti

Bioorg Med Chem· July 2006

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Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists.
Philip R Kym, Andrew J Souers, Thomas J Campbell, John K Lynch, Andrew S Judd, Jason A Segreti

J Med Chem· April 2006

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Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats.
James S Polakowski, Jason A Segreti, Bryan F Cox, Gin C Hsieh, Teodozyj Kolasa

Clin Exp Pharmacol Physiol· December 2004

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Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study.
Jason A Segreti, James S Polakowski, Kristin A Koch, Kennan C Marsh, Joy L Bauch

Cancer Chemother Pharmacol· September 2004

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Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
John T Randolph, Philip Waid, Charles Nichols, Daryl Sauer, Fortuna Haviv, Jason A Segreti

J Med Chem· February 2004

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Evaluation of tissue perfusion in a rat model of hind-limb muscle ischemia using dynamic contrast-enhanced magnetic resonance imaging.
Yanping Luo, Kurt M Mohning, Vincent P Hradil, Jerry L Wessale, Jason A Segreti

J Magn Reson Imaging· September 2002

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