Publications by authors named "Jason Cain"

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Targeting developmental vulnerabilities in childhood sarcomas.
Elise Young, Barnaby Kelly, Jason E Cain

Cancer Metastasis Rev· September 2025

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Correction: Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.
Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M Waszak, Stefan R Sweha, Jason E Cain

Cancer Discov· March 2025

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Multidimensional, integrative profiling identifies BCL2L1 methylation as a predictor of MCL1 dependency in pediatric malignancies.
Shazia Adjumain, Paul Daniel, Claire Xin Sun, Gabrielle Bradshaw, Nicole J Chew, Jason E Cain

JCI Insight· January 2025

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A STAT3-STING-IFN axis controls the metastatic spread of small cell lung cancer.
Aleks C Guanizo, Quinton Luong, W Samantha N Jayasekara, Eveline D de Geus, Chaitanya Inampudi, Jason E Cain

Nat Immunol· December 2024

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COLUMBIA-1: a randomised study of durvalumab plus oleclumab in combination with chemotherapy and bevacizumab in metastatic microsatellite-stable colorectal cancer.
Neil H Segal, Jeanne Tie, Scott Kopetz, Michel Ducreux, Eric Chen, Jason Cain

Br J Cancer· October 2024

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A Semiautomated Proteomics and Phosphoproteomics Protocol for the Identification of Novel Therapeutic Targets and Predictive Biomarkers in In Vivo Xenograft Models of Pediatric Cancers.
Terry C C Lim Kam Sian, Christie Sun, Jason E Cain, Joel R Steele, Iresha Hanchapola

Methods Mol Biol· April 2024

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Incorporating temporal information during feature engineering bolsters emulation of spatio-temporal emergence.
Jason Y Cain, Jacob I Evarts, Jessica S Yu, Neda Bagheri

Bioinformatics· March 2024

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PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.
Ryan J Duchatel, Evangeline R Jackson, Sarah G Parackal, Dylan Kiltschewskij, Izac J Findlay, Jason E Cain

J Clin Invest· February 2024

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Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype.
Vijesh G Vaghjiani, Catherine R Cochrane, W Samantha N Jayasekara, Wai Chin Chong, Anette Szczepny, Jason E Cain

Oncogene· November 2023

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Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Haematology/Oncology Group Study.
Christine L White, Kathryn M Kinross, Molly K Moore, Elnaz Rasouli, Robyn Strong, Jason E Cain

J Mol Diagn· October 2023

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ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.
Evangeline R Jackson, Ryan J Duchatel, Dilana E Staudt, Mika L Persson, Abdul Mannan, Jason E Cain

Cancer Res· May 2023

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ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma.
Evangeline R Jackson, Ryan J Duchatel, Dilana E Staudt, Mika L Persson, Abdul Mannan, Jason E Cain

Cancer Res· May 2023

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Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.
Claire Xin Sun, Paul Daniel, Gabrielle Bradshaw, Hui Shi, Melissa Loi, Jason E Cain

Cancer Cell· April 2023

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MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat.
Jasmine Chen, Aleks C Guanizo, W Samantha N Jakasekara, Chaitanya Inampudi, Quinton Luong, Jason E Cain

J Exp Clin Cancer Res· April 2023

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Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.
Zacary P Germon, Jonathan R Sillar, Abdul Mannan, Ryan J Duchatel, Dilana Staudt, Jason E Cain

Sci Signal· March 2023

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The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.
Jena V Lilly, Jo Lynne Rokita, Jennifer L Mason, Tatiana Patton, Stephanie Stefankiewiz, Jason Cain

Neoplasia· January 2023

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The in silico lab: Improving academic code using lessons from biology.
Jason Y Cain, Jessica S Yu, Neda Bagheri

Cell Syst· January 2023

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Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas.
Justyna M Przystal, Chiara Cianciolo Cosentino, Sridevi Yadavilli, Jie Zhang, Sandra Laternser, Jason E Cain

Neuro Oncol· September 2022

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Fighting fire with fire: deploying complexity in computational modeling to effectively characterize complex biological systems.
Alexis N Prybutok, Jason Y Cain, Joshua N Leonard, Neda Bagheri

Curr Opin Biotechnol· June 2022

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Distinctive molecular features of regenerative stem cells in the damaged male germline.
Hue M La, Jinyue Liao, Julien M D Legrand, Fernando J Rossello, Ai-Leen Chan, Jason E Cain

Nat Commun· May 2022

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Lineage-restricted neoplasia driven by Myc defaults to small cell lung cancer when combined with loss of p53 and Rb in the airway epithelium.
Jasmine Chen, Aleks Guanizo, Quinton Luong, W Samantha N Jayasekara, Dhilshan Jayasinghe, Jason E Cain

Oncogene· January 2022

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Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.
Izac J Findlay, Geoffry N De Iuliis, Ryan J Duchatel, Evangeline R Jackson, Nicholas A Vitanza, Jason E Cain

Oncogene· January 2022

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Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma.
Ryan J Duchatel, Abdul Mannan, Ameha S Woldu, Tom Hawtrey, Phoebe A Hindley, Jason E Cain

Neurooncol Adv· November 2021

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Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.
Wai C Chong, W Samantha N Jayasekara, Vijesh G Vaghjiani, Sarah Parackal, Claire Sun, Jason E Cain

Cancers (Basel)· October 2021

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