Publications by authors named "Jason D Speake"

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3D molecular descriptors important for clinical success.
David C Kombo, Kartik Tallapragada, Rachit Jain, Joseph Chewning, Anatoly A Mazurov, Jason D Speake

J Chem Inf Model· February 2013

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Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of α4β2* receptors.
Jiahui Zhang, Yun-De Xiao, Kristen G Jordan, Phil S Hammond, Katherine M Van Dyke, Jason D Speake

Eur J Pharm Sci· December 2012

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Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats.
Lisa C Loram, Frederick R Taylor, Keith A Strand, Steven F Maier, Jason D Speake

J Pain· December 2012

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Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
Anatoly A Mazurov, Lan Miao, Balwinder S Bhatti, Jon-Paul Strachan, Srinivasa Akireddy, Jason D Speake

J Med Chem· November 2012

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Discovery and development of α7 nicotinic acetylcholine receptor modulators.
Anatoly A Mazurov, Jason D Speake, Daniel Yohannes

J Med Chem· December 2011

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Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist.
Diane M Ignar, Aaron S Goetz, Kimberly Nichols Noble, Luz Helena Carballo, Andrea E Stroup, Jason D Speake

J Pharmacol Exp Ther· October 2011

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Tetrahydroquinoline derivatives as opioid receptor antagonists.
Cunyu Zhang, Susan M Westaway, Jason D Speake, Michael J Bishop, Aaron S Goetz

Bioorg Med Chem Lett· January 2011

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Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists.
Yuping Gong, Zhiyang Zhao, Donavon J McConn, Beth Beaudet, Melanie Tallman, Jason D Speake

Pharm Res· June 2007

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Novel benzimidazole-based MCH R1 antagonists.
Andrew J Carpenter, Kamal A Al-Barazanji, Kevin K Barvian, Michael J Bishop, Christy S Britt, Jason D Speake

Bioorg Med Chem Lett· October 2006

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2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds.
Jason D Speake, Frank Navas, Michael J Bishop, Deanna T Garrison, Eric C Bigham

Bioorg Med Chem Lett· March 2003

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Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines.
Stephen J Hodson, Eric C Bigham, Deanna T Garrison, Michael J Gobel, Paul E Irving, Jason D Speake

Bioorg Med Chem Lett· December 2002

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2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: the discovery of alpha1a subtype selective 2'-alkylsulfonyl-substituted analogues.
Stephen J Hodson, Michael J Bishop, Jason D Speake, Frank Navas, Deanna T Garrison

J Med Chem· May 2002

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alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.
Michael J Bishop, Kevin A Barvian, Judd Berman, Eric C Bigham, Deanna T Garrison, Jason D Speake

Bioorg Med Chem Lett· February 2002

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2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Frank Navas, Michael J Bishop, Deanna T Garrison, Stephen J Hodson, Jason D Speake

Bioorg Med Chem Lett· February 2002

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Synthetic Studies on Quassinoids: Total Synthesis and Biological Evaluation of (+)-Des-D-chaparrinone.
Paul A. Grieco, Jason D. Speake

J Org Chem· August 1998

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