Publications by authors named "Jason Dutra"

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C(sp)-C(sp) Suzuki-Miyaura Cross-Coupling Using -Bis(boronates).
Jun Xiao, Wen Xiu, Qingjian Zhang, John M Curto, Mengfan Jia, Jason Dutra

J Org Chem· October 2025

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Mechanistic differences between linear spirocyclic dialkyldiazirine probes for photoaffinity labeling.
Jessica G K O'Brien, Louis P Conway, Paramesh K Ramaraj, Appaso M Jadhav, Jun Jin, Jason K Dutra

Chem Sci· August 2024

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Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.
Shenping Liu, Ruth F Sommese, Nicole L Nedoma, Lucy Mae Stevens, Jason K Dutra

Nat Commun· August 2023

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Structural basis of the acyl-transfer mechanism of human GPAT1.
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Jason K Dutra

Nat Struct Mol Biol· January 2023

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Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.
Jason K Dutra, Timothy L Foley, Zhen Huang, Ethan L Fisher, Erik A Lachapelle

Chembiochem· May 2021

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Fluorophosphonate-Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics.
S Denise Field, Wankyu Lee, Jason K Dutra, Finley Scott F Serneo, Jon Oyer

Chembiochem· October 2020

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SuFEx Activation with Ca(NTf): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides.
Subham Mahapatra, Cristian P Woroch, Todd W Butler, Sabrina N Carneiro, Sabrina C Kwan, Jason K Dutra

Org Lett· June 2020

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Quantitative Analysis of F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain.
Akihiro Takano, Laigao Chen, Sangram Nag, Michael A Brodney, Ryosuke Arakawa, Jason K Dutra

J Nucl Med· July 2019

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Pharmacological evaluation of clinically relevant concentrations of (2R,6R)-hydroxynorketamine.
Christopher L Shaffer, Jason K Dutra, Wei Chou Tseng, Mark L Weber, Luke J Bogart

Neuropharmacology· July 2019

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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Brian T O'Neill, Elizabeth M Beck, Christopher R Butler, Charles E Nolan, Cathleen Gonzales, Jason K Dutra

J Med Chem· May 2018

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Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain.
Lei Zhang, Laigao Chen, Jason K Dutra, Elizabeth M Beck, Sangram Nag

J Med Chem· April 2018

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Trifluoromethyl Oxetanes: Synthesis and Evaluation as a tert-Butyl Isostere.
Paramita Mukherjee, Martin Pettersson, Jason K Dutra, Longfei Xie, Christopher W Am Ende

ChemMedChem· October 2017

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Utilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.
Michael A Brodney, Elizabeth M Beck, Christopher R Butler, Gabriela Barreiro, Eric F Johnson, Jason Dutra

J Med Chem· April 2015

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Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.
Christopher R Butler, Michael A Brodney, Elizabeth M Beck, Gabriela Barreiro, Charles E Nolan, Jason K Dutra

J Med Chem· March 2015

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Stereoselective synthesis of spiropiperidines as BACE-1 aspartyl protease inhibitors via late stage N-arylation of a 1,8-diazaspiro[4.5]dec-3-en-2-one pharmacophore.
Che-Wah Lee, Ricardo Lira, Jason Dutra, Kevin Ogilvie, Brian T O'Neill

J Org Chem· March 2013

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Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.
Ivan V Efremov, Felix F Vajdos, Kris A Borzilleri, Steven Capetta, Hou Chen, Jason K Dutra

J Med Chem· November 2012

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Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
Antonia F Stepan, Chakrapani Subramanyam, Ivan V Efremov, Jason K Dutra, Theresa J O'Sullivan

J Med Chem· April 2012

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Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
Antonia F Stepan, Kapil Karki, W Scott McDonald, Peter H Dorff, Jason K Dutra

J Med Chem· November 2011

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Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.
Hengmiao Cheng, Kristin M Lundy DeMello, Jin Li, Subas M Sakya, Kazuo Ando, Jason K Dutra

Bioorg Med Chem Lett· April 2006

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5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.
Subas M Sakya, Hengmiao Cheng, Kristin M Lundy Demello, Andrei Shavnya, Martha L Minich, Jason Dutra

Bioorg Med Chem Lett· March 2006

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.
Jin Li, Kristin M Lundy DeMello, Henry Cheng, Subas M Sakya, Brian S Bronk, Jason K Dutra

Bioorg Med Chem Lett· January 2004

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Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent Gram-positive and Gram-negative antibacterial agents.
Hengmiao Cheng, John P Dirlam, Carl B Ziegler, Kristin M Lundy, Shigeru F Hayashi, Jason K Dutra

Bioorg Med Chem Lett· September 2002

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