Publications by authors named "Jason P Lynch"

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Development and characterization of AD-214, an anti-CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosis.
Jason P Lynch, Louise Organ, Khamis Tomusange, Lukasz Kowalczyk, Dallas J Hartman

MAbs· December 2025

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deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic .
Rajkamal Srivastava, Coral González-Prieto, Jason P Lynch, Michele E Muscolo, Catherine Y Lin

PNAS Nexus· September 2024

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deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic .
Rajkamal Srivastava, Coral González-Prieto, Jason P Lynch, Michele Muscolo, Catherine Y Lin

bioRxiv· July 2024

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PROTEcT, engineered Escherichia coli for the targeted delivery of therapeutics.
Coral González-Prieto, Jason P Lynch, Cammie F Lesser

Trends Mol Med· November 2023

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Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection.
Md Al Amin Sikder, Ridwan B Rashid, Tufael Ahmed, Ismail Sebina, Daniel R Howard, Jason P Lynch

Immunity· May 2023

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Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.
Jason P Lynch, Coral González-Prieto, Analise Z Reeves, Sena Bae, Urmila Powale

Cell Host Microbe· April 2023

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Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics.
Jason P Lynch, Lisa Goers, Cammie F Lesser

Trends Pharmacol Sci· September 2022

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Targeting the P2Y Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.
Rhiannon B Werder, Md Ashik Ullah, Muhammed Mahfuzur Rahman, Jennifer Simpson, Jason P Lynch

Am J Respir Crit Care Med· February 2022

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Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
Jennifer Cable, Joshua N Leonard, Timothy K Lu, Zhen Xie, Matthew Wook Chang, Jason P Lynch

Ann N Y Acad Sci· December 2021

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Bone Marrow Regulatory T Cells Are a Unique Population, Supported by Niche-Specific Cytokines and Plasmacytoid Dendritic Cells, and Required for Chronic Graft-Versus-Host Disease Control.
Jemma Nicholls, Benjamin Cao, Laetitia Le Texier, Laura Yan Xiong, Christopher R Hunter, Jason P Lynch

Front Cell Dev Biol· September 2021

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A host metabolite promotes survival.
Jason P Lynch, Cammie F Lesser

Science· January 2021

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Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma.
Jason P Lynch, Rhiannon B Werder, Bodie F Curren, Md Al Amin Sikder, Ashik Ullah

Mucosal Immunol· July 2020

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HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling.
Zhixuan Loh, Jennifer Simpson, Ashik Ullah, Vivian Zhang, Wan J Gan, Jason P Lynch

PLoS Pathog· July 2020

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Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells.
Jennifer Simpson, Zhixuan Loh, Md Ashik Ullah, Jason P Lynch, Rhiannon B Werder

Am J Respir Crit Care Med· June 2020

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Host-Pathogen Interactions: What the EHEC Are We Learning from Host Genome-Wide Screens?
Jason P Lynch, Cammie F Lesser

mBio· October 2018

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Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity.
Rhiannon B Werder, Vivian Zhang, Jason P Lynch, Natale Snape, John W Upham

J Allergy Clin Immunol· May 2018

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PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN- production.
Rhiannon B Werder, Jason P Lynch, Jennifer C Simpson, Vivian Zhang, Nick H Hodge

Sci Transl Med· May 2018

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Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion.
Jason P Lynch, Rhiannon B Werder, Zhixuan Loh, Md Al Amin Sikder, Bodie Curren

J Exp Med· February 2018

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Critical Role of Plasmacytoid Dendritic Cells in Regulating Gene Expression and Innate Immune Responses to Human Rhinovirus-16.
Yang Xi, Niamh M Troy, Denise Anderson, Olga M Pena, Jason P Lynch

Front Immunol· October 2017

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The Absence of Interferon-β Promotor Stimulator-1 (IPS-1) Predisposes to Bronchiolitis and Asthma-like Pathology in Response to Pneumoviral Infection in Mice.
Jennifer Simpson, Jason P Lynch, Zhixuan Loh, Vivian Zhang, Rhiannon B Werder

Sci Rep· May 2017

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The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma-Food for Thought?
Jason P Lynch, Md Al Amin Sikder, Bodie F Curren, Rhiannon B Werder, Jennifer Simpson

Front Immunol· February 2017

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Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity.
Jason P Lynch, Rhiannon B Werder, Jennifer Simpson, Zhixuan Loh, Vivian Zhang

J Allergy Clin Immunol· November 2016

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Th2/Th17 reciprocal regulation: twists and turns in the complexity of asthma phenotypes.
Jason P Lynch, Manuel A Ferreira, Simon Phipps

Ann Transl Med· October 2016

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Immunomodulation of airway epithelium cell activation by mesenchymal stromal cells ameliorates house dust mite-induced airway inflammation in mice.
Khang M Duong, Jaisy Arikkatt, M Ashik Ullah, Jason P Lynch, Vivian Zhang

Am J Respir Cell Mol Biol· November 2015

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Regulatory T cells prevent inducible BALT formation by dampening neutrophilic inflammation.
Shen Yun Foo, Vivian Zhang, Amit Lalwani, Jason P Lynch, Aowen Zhuang

J Immunol· May 2015

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