Publications by authors named "Jason Phan"

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Nuclear Magnetic Resonance-based fragment screen of the E3 ligase Fem-1 homolog B.
Jade M Katinas, Kangsa Amporndanai, Ashley J Taylor, Kristie L Rose, Peter C Gareiss, Jason Phan

Protein Sci· December 2025

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Identification of ligands for E3 ligases with restricted expression using fragment-based methods.
Alex G Waterson, Brian D Lehmann, Zhenwei Lu, John L Sensintaffar, Edward T Olejniczak, Jason Phan

RSC Chem Biol· October 2025

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Discovery of BI-2493, a Pan-KRAS Inhibitor Showing Efficacy.
Joachim Bröker, Alex G Waterson, Timothy R Hodges, Jason R Abbott, Allison Arnold, Jason Phan

J Med Chem· August 2025

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Taking a Pulse on Quality and Safety Education: An Analysis of the 2022 National Sample Survey of Registered Nurses.
Maja Djukic, Chantell Thompson, Zhichun Ke, Jason Phan, Nikhil Padhye

Nurse Educ· April 2025

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Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2).
Krzysztof M Zak, Alex G Waterson, Leonhard Geist, Nina Braun, Katja Hauer, Jason Phan

J Med Chem· February 2025

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Fragment-Based Screen of SARS-CoV-2 Papain-like Protease (PL).
Ashley J Taylor, Kangsa Amporndanai, Tyson A Rietz, Bin Zhao, Anusha Thiruvaipati, Jason Phan

ACS Med Chem Lett· August 2024

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS Inhibitor.
Joachim Bröker, Alex G Waterson, Chris Smethurst, Dirk Kessler, Jark Böttcher, Jason Phan

J Med Chem· November 2022

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Physical Therapy for Gait, Balance, and Cognition in Individuals with Cognitive Impairment: A Retrospective Analysis.
Jason Longhurst, Jason Phan, Elbert Chen, Steven Jackson, Merrill R Landers

Rehabil Res Pract· November 2020

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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
Dhruba Sarkar, Edward T Olejniczak, Jason Phan, Jesse A Coker, Jiqing Sai

J Med Chem· August 2020

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Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design.
Selena Chacón Simon, Feng Wang, Lance R Thomas, Jason Phan, Bin Zhao

J Med Chem· April 2020

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Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.
Dirk Kessler, Andreas Gollner, Michael Gmachl, Andreas Mantoulidis, Laetitia J Martin, Jason Phan

Proc Natl Acad Sci U S A· February 2020

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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
Jonathan D Macdonald, Selena Chacón Simon, Changho Han, Feng Wang, J Grace Shaw, Jason Phan

J Med Chem· December 2019

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Drugging an undruggable pocket on KRAS.
Dirk Kessler, Michael Gmachl, Andreas Mantoulidis, Laetitia J Martin, Andreas Zoephel, Jason Phan

Proc Natl Acad Sci U S A· August 2019

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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.
Denis T Akan, Jennifer E Howes, Jiqing Sai, Allison L Arnold, Yugandhar Beesetty, Jason Phan

ACS Chem Biol· March 2019

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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.
Erin R Aho, Jing Wang, Rocco D Gogliotti, Gregory C Howard, Jason Phan

Cell Rep· March 2019

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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Timothy R Hodges, Jason R Abbott, Andrew J Little, Dhruba Sarkar, James M Salovich, Jason Phan

J Med Chem· October 2018

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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
Jason R Abbott, Pratiq A Patel, Jennifer E Howes, Denis T Akan, J Phillip Kennedy, Jason Phan

ACS Med Chem Lett· September 2018

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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Jason R Abbott, Timothy R Hodges, R Nathan Daniels, Pratiq A Patel, J Phillip Kennedy, Jason Phan

J Med Chem· July 2018

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Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
Feng Wang, Kyu Ok Jeon, James M Salovich, Jonathan D Macdonald, Joseph Alvarado, Jason Phan

J Med Chem· July 2018

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High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Michael C Burns, Jennifer E Howes, Qi Sun, Andrew J Little, DeMarco V Camper, Jason Phan

Anal Biochem· May 2018

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Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes.
Qian Shi, Minghui Li, Delphine Mika, Qin Fu, Sungjin Kim, Jason Phan

Cardiovasc Res· May 2017

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Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.
Lance R Thomas, Qingguo Wang, Brian C Grieb, Jason Phan, Audra M Foshage

Mol Cell· May 2015

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Fragment-based screening of the bromodomain of ATAD2.
Mary J Harner, Brian A Chauder, Jason Phan, Stephen W Fesik

J Med Chem· November 2014

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A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
Qi Sun, Jason Phan, Anders R Friberg, DeMarco V Camper, Edward T Olejniczak

J Biomol NMR· September 2014

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Michael C Burns, Qi Sun, R Nathan Daniels, DeMarco Camper, J Phillip Kennedy, Jason Phan

Proc Natl Acad Sci U S A· March 2014

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