Publications by authors named "Jason Pickens"

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Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis.
Emma L Shepherd, Raquel Saborano, Ellie Northall, Kae Matsuda, Hitomi Ogino, Jason Pickens

JHEP Rep· April 2021

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Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp character and an exquisite selectivity profile.
Simone V Bigi-Botterill, Anthony Ivetac, Erica L Bradshaw, Derek Cole, Douglas R Dougan, Jason Pickens

Bioorg Med Chem Lett· September 2020

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Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure".
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers

ACS Med Chem Lett· December 2017

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Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers

ACS Med Chem Lett· March 2017

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Heterobiaryl human immunodeficiency virus entry inhibitors.
Rong-Jian Lu, John A Tucker, Jason Pickens, You-An Ma, Tatiana Zinevitch

J Med Chem· July 2009

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Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group.
Rong-Jian Lu, John A Tucker, Tatiana Zinevitch, Olga Kirichenko, Vitalii Konoplev, Jason Pickens

J Med Chem· December 2007

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Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.
Rongshi Li, Liquan Xue, Tong Zhu, Qin Jiang, Xiaoli Cui, Jason C Pickens

J Med Chem· February 2006

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Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin.
Erkang Fan, Claire J O'Neal, Daniel D Mitchell, Mark A Robien, Zhongsheng Zhang, Jason C Pickens

Int J Med Microbiol· October 2004

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Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.
Jason C Pickens, Daniel D Mitchell, Jiyun Liu, Xiaojian Tan, Zhongsheng Zhang

Chem Biol· September 2004

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Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design.
Zhongsheng Zhang, Jason C Pickens, Wim G J Hol, Erkang Fan

Org Lett· April 2004

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3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies.
Daniel D Mitchell, Jason C Pickens, Konstantin Korotkov, Erkang Fan, Wim G J Hol

Bioorg Med Chem· March 2004

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Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.
Ethan A Merritt, Zhongsheng Zhang, Jason C Pickens, Misol Ahn, Wim G J Hol

J Am Chem Soc· July 2002

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Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Jason C Pickens, Ethan A Merritt, Misol Ahn, Christophe L M J Verlinde, Wim G J Hol

Chem Biol· February 2002

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