Publications by authors named "Derek Cole"

Claim this Profile
S
Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp character and an exquisite selectivity profile.
Simone V Bigi-Botterill, Anthony Ivetac, Erica L Bradshaw, Derek Cole, Douglas R Dougan

Bioorg Med Chem Lett· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Bleeding rates of Veterans taking apixaban or rivaroxaban for atrial fibrillation or venous thromboembolism.
Zachary Howe, Chad Naville-Cook, Derek Cole

J Thromb Thrombolysis· February 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure".
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers, Derek Cole

ACS Med Chem Lett· December 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.
Marion Lanier, Derek C Cole, Yelena Istratiy, Michael G Klein, Phillip A Schwartz

J Med Chem· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-based drug design of novel ASK1 inhibitors using an integrated lead optimization strategy.
Tony S Gibson, Benjamin Johnson, Andrea Fanjul, Petro Halkowycz, Douglas R Dougan, Derek Cole

Bioorg Med Chem Lett· April 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers, Derek Cole

ACS Med Chem Lett· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
Marion Lanier, Geza Ambrus, Derek C Cole, Richard Davenport, Jonathan Ellery

J Med Chem· June 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification and SAR of a new series of thieno[3,2-d]pyrimidines as Tpl2 kinase inhibitors.
Yike Ni, Ariamala Gopalsamy, Derek Cole, Yonghan Hu, Rajiah Denny

Bioorg Med Chem Lett· October 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of indazoles as inhibitors of Tpl2 kinase.
Yonghan Hu, Derek Cole, Rajiah Aldrin Denny, David R Anderson, Manus Ipek

Bioorg Med Chem Lett· August 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification and characterization of acidic mammalian chitinase inhibitors.
Derek C Cole, Andrea M Olland, Jaison Jacob, Jon Brooks, Matthew G Bursavich

J Med Chem· August 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A fluorescent assay suitable for inhibitor screening and vanin tissue quantification.
Benfang H Ruan, Derek C Cole, Paul Wu, Amira Quazi, Karen Page

Anal Biochem· April 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists.
Derek C Cole, Jonathan L Gross, Thomas A Comery, Suzan Aschmies, Warren D Hirst

Bioorg Med Chem Lett· February 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Pawel Nowak, Derek C Cole, Ann Aulabaugh, Jonathan Bard, Rajiv Chopra

Bioorg Med Chem Lett· January 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of a new class of small molecule C5a receptor antagonists.
Jack J Chen, Derek C Cole, Greg Ciszewski, Kimberly Crouse, John W Ellingboe

Bioorg Med Chem Lett· January 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.
Pawel Nowak, Derek C Cole, Natasja Brooijmans, Matthew G Bursavich, Kevin J Curran

J Med Chem· November 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.
Ker Yu, Lourdes Toral-Barza, Celine Shi, Wei-Guo Zhang, Judy Lucas, Derek C Cole

Cancer Res· August 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.
Ronald C Bernotas, Steven Lenicek, Schuyler Antane, Derek C Cole, Boyd L Harrison

Bioorg Med Chem· July 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles.
Russell G Dushin, Thomas Nittoli, Charles Ingalls, Diane H Boschelli, Derek C Cole

Bioorg Med Chem Lett· May 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
(
(S)-N-(5-Chlorothiophene-2-sulfonyl)-beta,beta-diethylalaninol a Notch-1-sparing gamma-secretase inhibitor.
Derek C Cole, Joseph R Stock, Anthony F Kreft, Madelene Antane, Suzan H Aschmies

Bioorg Med Chem Lett· February 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Scott C Mayer, Anthony F Kreft, Boyd Harrison, Magid Abou-Gharbia, Madelene Antane, Derek C Cole

J Med Chem· December 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors.
Derek C Cole, Magda Asselin, Agnes Brennan, Robert Czerwinski, John W Ellingboe

J Med Chem· October 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Human germline and somatic cells have similar TP53 and Kirsten-RAS gene single base mutation frequencies.
Derek N Cole, J Andrew Carlson, Vincent L Wilson

Environ Mol Mutagen· July 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.
Anthony Kreft, Boyd Harrison, Suzan Aschmies, Kevin Atchison, David Casebier, Derek C Cole

Bioorg Med Chem Lett· July 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.
Jun Xu, Derek C Cole, Chao-Pei Betty Chang, Ramzi Ayyad, Magda Asselin

J Med Chem· July 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.
Diane H Boschelli, Biqi Wu, Ana Carolina Barrios Sosa, Joan Chen, Magda Asselin, Derek C Cole

Bioorg Med Chem Lett· May 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis