Publications by authors named "Jason R Zbieg"

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TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway.
Alissa D Guarnaccia, Thijs J Hagenbeek, Wendy Lee, Noelyn Kljavin, Meena Choi, Jason R Zbieg

Proc Natl Acad Sci U S A· July 2025

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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance.
Thijs J Hagenbeek, Jason R Zbieg, Marc Hafner, Rana Mroue, Jennifer A Lacap

Nat Cancer· June 2023

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Chiral Amines via Enantioselective π-Allyliridium-,-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration.
Craig E Stivala, Jason R Zbieg, Peng Liu, Michael J Krische

Acc Chem Res· August 2022

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Kinetic, ESI-CID-MS and Computational Studies of π-Allyliridium -Benzoate-Catalyzed Allylic Amination: Understanding the Effect of Cesium Ion.
Woo-Ok Jung, Binh Khanh Mai, Minjin Yoo, Samuel W J Shields, Jason R Zbieg

ACS Catal· March 2022

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Regio- and Enantioselective Iridium-Catalyzed Amination of Alkyl-Substituted Allylic Acetates with Secondary Amines.
Woo-Ok Jung, Minjin Yoo, Madyson M Migliozzi, Jason R Zbieg, Craig E Stivala

Org Lett· January 2022

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The Direct Decarboxylative -Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis.
Peijun Li, Jason R Zbieg, Jack A Terrett

Org Lett· December 2021

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Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Jason R Zbieg, Jun Liang, Jun Li, Robert A Blake, Jae Chang

Bioorg Med Chem Lett· October 2021

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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
Jun Liang, Jason R Zbieg, Robert A Blake, Jae H Chang, Stephen Daly

J Med Chem· August 2021

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Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to β-Stereogenic α-Quaternary Primary Amines.
Woo-Ok Jung, Binh Khanh Mai, Brian J Spinello, Zachary J Dubey, Seung Wook Kim, Jason R Zbieg

J Am Chem Soc· June 2021

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Visible-Light Photocatalysis as an Enabling Technology for Drug Discovery: A Paradigm Shift for Chemical Reactivity.
Peijun Li, Jack A Terrett, Jason R Zbieg

ACS Med Chem Lett· November 2020

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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.
Jeffrey K Holden, James J Crawford, Cameron L Noland, Stephen Schmidt, Jason R Zbieg

Cell Rep· June 2020

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cis-Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N-sulfonyl N,S-acetals.
Shao-Xiong Lennon Luo, Yanzhou Liu, Michael J Lambrecht, Daniel F Ortwine, Antonio G DiPasquale, Jason R Zbieg

Org Biomol Chem· November 2019

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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
Sharada S Labadie, Jun Li, Robert A Blake, Jae H Chang, Simon Goodacre, Jason R Zbieg

Bioorg Med Chem Lett· August 2019

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An Integrated Analysis of Solid Form Change Impact on Solubility and Permeability: Case Study of Oral Exposure in Rats of an RAR Related Orphan Receptor C Inhibitor.
Po-Chang Chiang, Karthik Nagapudi, Jia Liu, James J Crawford, Jason R Zbieg

J Pharm Sci· July 2019

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Regio- and Enantioselective Iridium-Catalyzed N-Allylation of Indoles and Related Azoles with Racemic Branched Alkyl-Substituted Allylic Acetates.
Seung Wook Kim, Tabitha T Schempp, Jason R Zbieg, Craig E Stivala, Michael J Krische

Angew Chem Int Ed Engl· June 2019

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Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines.
Seung Wook Kim, Leyah A Schwartz, Jason R Zbieg, Craig E Stivala, Michael J Krische

J Am Chem Soc· January 2019

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Hippo pathway inhibition by blocking the YAP/TAZ-TEAD interface: a patent review.
James J Crawford, Sarah M Bronner, Jason R Zbieg

Expert Opin Ther Pat· December 2018

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Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity.
Seung Wook Kim, Thomas Wurm, Gilmar A Brito, Woo-Ok Jung, Jason R Zbieg

J Am Chem Soc· July 2018

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Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups.
Arismel Tena Meza, Thomas Wurm, Lewis Smith, Seung Wook Kim, Jason R Zbieg

J Am Chem Soc· January 2018

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RORγ antagonists and inverse agonists: a patent review.
Sarah M Bronner, Jason R Zbieg, James J Crawford

Expert Opin Ther Pat· January 2017

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Simple catalytic mechanism for the direct coupling of α-carbonyls with functionalized amines: a one-step synthesis of Plavix.
Ryan W Evans, Jason R Zbieg, Shaolin Zhu, Wei Li, David W C MacMillan

J Am Chem Soc· October 2013

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Direct, redox-neutral prenylation and geranylation of secondary carbinol C-H bonds: C4-regioselectivity in ruthenium-catalyzed C-C couplings of dienes to α-hydroxy esters.
Joyce C Leung, Laina M Geary, Te-Yu Chen, Jason R Zbieg, Michael J Krische

J Am Chem Soc· September 2012

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Enantioselective C-H crotylation of primary alcohols via hydrohydroxyalkylation of butadiene.
Jason R Zbieg, Eiji Yamaguchi, Emma L McInturff, Michael J Krische

Science· April 2012

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Diastereo- and enantioselective ruthenium-catalyzed hydrohydroxyalkylation of 2-silyl-butadienes: carbonyl syn-crotylation from the alcohol oxidation level.
Jason R Zbieg, Joseph Moran, Michael J Krische

J Am Chem Soc· July 2011

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Enantioselective iridium-catalyzed vinylogous Reformatsky-aldol reaction from the alcohol oxidation level: linear regioselectivity by way of carbon-bound enolates.
Abbas Hassan, Jason R Zbieg, Michael J Krische

Angew Chem Int Ed Engl· April 2011

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