Publications by authors named "Jason Thresher"

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ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.
Thomas F Durand-Réville, Satenig Guler, Janelle Comita-Prevoir, Brendan Chen, Neil Bifulco, Jason Thresher

Nat Microbiol· June 2017

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Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.
Sushmita D Lahiri, Grant K Walkup, James D Whiteaker, Tiffany Palmer, Kathy McCormack, Jason Thresher

J Antimicrob Chemother· February 2016

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Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
Gunther Kern, Tiffany Palmer, David E Ehmann, Adam B Shapiro, Beth Andrews, Jason Thresher

J Biol Chem· August 2015

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Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii.
William F Penwell, Adam B Shapiro, Robert A Giacobbe, Rong-Fang Gu, Ning Gao, Jason Thresher

Antimicrob Agents Chemother· March 2015

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Mechanism of action for respiratory syncytial virus inhibitor RSV604.
SreeRupa Challa, Andrew D Scott, Olga Yuzhakov, Ying Zhou, Choi Lai Tiong-Yip, Jason Thresher

Antimicrob Agents Chemother· February 2015

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Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.
Asha S Nayar, Thomas J Dougherty, Folkert Reck, Jason Thresher, Ning Gao

Antimicrob Agents Chemother· January 2015

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Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.
Ning Gao, Sarah M McLeod, Laurel Hajec, Nelson B Olivier, Sushmita D Lahiri, Jason Thresher

Protein Expr Purif· December 2014

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Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein.
Adam B Shapiro, Ning Gao, Nichole O'Connell, Jun Hu, Jason Thresher

Virol J· November 2014

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Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.
Kerry E Murphy-Benenato, Nelson Olivier, Allison Choy, Philip L Ross, Matthew D Miller, Jason Thresher

ACS Med Chem Lett· November 2014

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Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.
Adam B Shapiro, Ning Gao, Rong-Fang Gu, Jason Thresher

Anal Biochem· October 2014

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Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening.
Adam B Shapiro, Helen Plant, Jarrod Walsh, Mark Sylvester, Jun Hu, Jason Thresher

J Biomol Screen· September 2014

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Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.
Boudewijn L M de Jonge, Grant K Walkup, Sushmita D Lahiri, Hoan Huynh, Georg Neckermann, Jason Thresher

Antimicrob Agents Chemother· December 2013

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Kinetics of avibactam inhibition against Class A, C, and D β-lactamases.
David E Ehmann, Haris Jahic, Philip L Ross, Rong-Fang Gu, Jun Hu, Jason Thresher

J Biol Chem· September 2013

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Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
Pamela J Hill, Ayome Abibi, Robert Albert, Beth Andrews, Moriah M Gagnon, Jason Thresher

J Med Chem· September 2013

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Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3.
Adam B Shapiro, Rong-Fang Gu, Ning Gao, Stephania Livchak, Jason Thresher

Anal Biochem· August 2013

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Exploring the UDP pocket of LpxC through amino acid analogs.
Michael R Hale, Pamela Hill, Sushmita Lahiri, Matthew D Miller, Philip Ross, Jason Thresher

Bioorg Med Chem Lett· April 2013

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A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA).
Adam B Shapiro, Philip L Ross, Ning Gao, Stephania Livchak, Gunther Kern, Jason Thresher

J Biomol Screen· March 2013

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The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds.
Haris Jahić, Ce Feng Liu, Jason Thresher, Stephania Livchak, Hongming Wang

Biochem Pharmacol· September 2012

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A homogeneous, high-throughput-compatible, fluorescence intensity-based assay for UDP-N-acetylenolpyruvylglucosamine reductase (MurB) with nanomolar product detection.
Adam B Shapiro, Stephania Livchak, Ning Gao, James Whiteaker, Jason Thresher

J Biomol Screen· March 2012

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A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase.
Adam B Shapiro, Ning Gao, Jason Thresher, Grant K Walkup, James Whiteaker

J Biomol Screen· June 2011

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A homogeneous, high-throughput fluorescence anisotropy-based DNA supercoiling assay.
Adam Shapiro, Haris Jahic, Swati Prasad, David Ehmann, Jason Thresher

J Biomol Screen· October 2010

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