Publications by authors named "Jay Kalin"

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The Allosteric Regulator Inositol Phosphate Dramatically Affects the Efficacy and Selectivity of Inhibitors for Different HDAC Complexes.
Wiktoria A Pytel, Urvashi Patel, Joshua P Smalley, Christopher J Millard, Edward A Brown, Jay H Kalin

J Am Chem Soc· October 2025

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Discovery of a non-nucleoside inhibitor that binds to a novel site in the palm domain of the respiratory syncytial virus RNA-dependent RNA polymerase.
Jay H Kalin, Yanting Yin, Minh T Tran, Madison Piassek, Amy Fung

J Virol· July 2025

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Targeting NEDD9-SH3 with a Covalent Peptide Controls Endothelial Phenotype.
Andriy O Samokhin, Hyuk-Soo Seo, Alison Leed, Behnoush Hajian, Gregory H Bird, Jay H Kalin

bioRxiv· July 2025

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DNA-Encoded Library Screen Identifies Novel Series of Respiratory Syncytial Virus Polymerase Inhibitors.
Sean M Carney, Sandrine Grosse, Yanting Yin, Minh T Tran, Jay H Kalin

J Med Chem· March 2025

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Expression of Concern: A Novel Role for Histone Deacetylase 6 in the Regulation of the Tolerogenic STAT3/IL-10 Pathway in APCs.
Fengdong Cheng, Maritza Lienlaf, Hong-Wei Wang, Patricio Perez-Villarroel, Calvin Lee, Jay Kalin

J Immunol· October 2024

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Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration.
Maki Kida, Iqra Fatima, Elena Rozhkova, Marta Otero-Viñas, Muzhou Wu, Jay H Kalin

J Invest Dermatol· February 2024

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The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma.
Muzhou Wu, Ailish Hanly, Frederick Gibson, Robert Fisher, Samantha Rogers, Jay H Kalin

J Clin Invest· February 2024

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Chemical modulation of lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Gilda Padalino, Cassandra A Celatka, Hugh Y Rienhoff, Jay H Kalin, Philip A Cole

Wellcome Open Res· March 2023

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Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Elsie Diaz, Suraj Adhikary, Armand W J W Tepper, Daniel Riley, Rodrigo Ortiz-Meoz, Jay H Kalin

Commun Biol· August 2022

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Development and characterization of rabbit monoclonal antibodies that recognize human spermine oxidase and application to immunohistochemistry of human cancer tissues.
Armand W J W Tepper, Gerald Chu, Vincent N A Klaren, Jay H Kalin, Patricia Molina-Ortiz

PLoS One· April 2022

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HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury.
David D Aufhauser, Paul Hernandez, Seth J Concors, Ciaran O'Brien, Zhonglin Wang, Jay H Kalin

Sci Rep· April 2021

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Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
Yan Xiong, Liqing Wang, Eros Di Giorgio, Tatiana Akimova, Ulf H Beier, Jay H Kalin

J Clin Invest· April 2020

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Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in -Mutant Colorectal Cancer.
Samuel A Miller, Robert A Policastro, Sudha S Savant, Shruthi Sriramkumar, Ning Ding, Jay H Kalin

Mol Cancer Res· February 2020

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Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.
Jay H Kalin, Abdulkerim Eroglu, Hua Liu, W David Holtzclaw, Irene Leigh

PLoS One· December 2019

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Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.
Jamie N Anastas, Barry M Zee, Jay H Kalin, Mirhee Kim, Robyn Guo

Cancer Cell· November 2019

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Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms.
Daniel R Dempsey, Hanjie Jiang, Jay H Kalin, Zan Chen, Philip A Cole

J Am Chem Soc· August 2018

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Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex.
Mingxuan Wu, Dawn Hayward, Jay H Kalin, Yun Song, John Wr Schwabe

Elife· June 2018

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Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Jay H Kalin, Muzhou Wu, Andrea V Gomez, Yun Song, Jayanta Das

Nat Commun· January 2018

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An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor.
Po-Yuan Hsiao, Jay H Kalin, Im-Hong Sun, Mohammed N Amin, Ying-Chun Lo

Chembiochem· October 2016

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Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease.
Sida Shen, Veronick Benoy, Joel A Bergman, Jay H Kalin, Mariana Frojuello

ACS Chem Neurosci· February 2016

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Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide.
Shuiyu Lu, Yi Zhang, Jay H Kalin, Lisheng Cai, Alan P Kozikowski

J Labelled Comp Radiopharm· January 2016

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A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs.
Fengdong Cheng, Maritza Lienlaf, Hong-Wei Wang, Patricio Perez-Villarroel, Calvin Lee, Jay Kalin

J Immunol· September 2014

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A selective phenelzine analogue inhibitor of histone demethylase LSD1.
Polina Prusevich, Jay H Kalin, Shonoi A Ming, Manuela Basso, Jeffrey Givens

ACS Chem Biol· June 2014

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Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition.
Maj-Linda Selenica, Leif Benner, Steven B Housley, Barbara Manchec, Daniel C Lee, Jay Kalin

Alzheimers Res Ther· May 2014

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An Fc domain protein-small molecule conjugate as an enhanced immunomodulator.
Meng-Jung Chiang, Marc A Holbert, Jay H Kalin, Young-Hoon Ahn, John Giddens

J Am Chem Soc· March 2014

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